Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon
Abstract Background Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmiss...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-9-321 https://doaj.org/article/ad0eee914d8b4fc0bbe37d8b8451b22f |
id |
ftdoajarticles:oai:doaj.org/article:ad0eee914d8b4fc0bbe37d8b8451b22f |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ad0eee914d8b4fc0bbe37d8b8451b22f 2023-05-15T15:16:50+02:00 Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric 2010-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-321 https://doaj.org/article/ad0eee914d8b4fc0bbe37d8b8451b22f EN eng BMC http://www.malariajournal.com/content/9/1/321 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-321 1475-2875 https://doaj.org/article/ad0eee914d8b4fc0bbe37d8b8451b22f Malaria Journal, Vol 9, Iss 1, p 321 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-321 2022-12-31T03:20:18Z Abstract Background Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops. Methods Mosquitoes sampled by human landing collection were identified morphologically and by molecular methods. The Plasmodium falciparum circumsporozoïte (CSP) indexes were measured by ELISA, and the entomological inoculation rates (EIR) were calculated for both areas. Molecular assessments of pyrethroid knock down (kdr ) resistance and of insensitive acetylcholinesterase resistance were conducted. Results In Libreville, Anopheles gambiae s.s . S form was the only specie of the An. gambiae complex present and was responsible of 9.4 bites per person per night. The circumsporozoïte index was 0.15% and the entomological inoculation rate estimated to be 1.23 infective bites during the four months period. In Port-Gentil, Anopheles melas (75.5% of catches) and An. gambiae s.s . S form (24.5%) were responsible of 58.7 bites per person per night. The CSP indexes were of 1.67% for An. gambiae s.s and 0.28% for An. melas and the EIRs were respectively of 1.8 infective bites per week and of 0.8 infective bites per week. Both kdr-w and kdr-e mutations in An. gambiae S form were found in Libreville and in Port-Gentil. Insensitive acetylcholinesterase has been detected for the first time in Gabon in Libreville. Conclusion Malaria transmission exists in both town, but with high difference in the level of risk. The co-occurrence of molecular resistances to the main families of insecticide has implications for the effectiveness of the current vector control programmes that are based on pyrethroid-impregnated bed nets. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 321 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops. Methods Mosquitoes sampled by human landing collection were identified morphologically and by molecular methods. The Plasmodium falciparum circumsporozoïte (CSP) indexes were measured by ELISA, and the entomological inoculation rates (EIR) were calculated for both areas. Molecular assessments of pyrethroid knock down (kdr ) resistance and of insensitive acetylcholinesterase resistance were conducted. Results In Libreville, Anopheles gambiae s.s . S form was the only specie of the An. gambiae complex present and was responsible of 9.4 bites per person per night. The circumsporozoïte index was 0.15% and the entomological inoculation rate estimated to be 1.23 infective bites during the four months period. In Port-Gentil, Anopheles melas (75.5% of catches) and An. gambiae s.s . S form (24.5%) were responsible of 58.7 bites per person per night. The CSP indexes were of 1.67% for An. gambiae s.s and 0.28% for An. melas and the EIRs were respectively of 1.8 infective bites per week and of 0.8 infective bites per week. Both kdr-w and kdr-e mutations in An. gambiae S form were found in Libreville and in Port-Gentil. Insensitive acetylcholinesterase has been detected for the first time in Gabon in Libreville. Conclusion Malaria transmission exists in both town, but with high difference in the level of risk. The co-occurrence of molecular resistances to the main families of insecticide has implications for the effectiveness of the current vector control programmes that are based on pyrethroid-impregnated bed nets. |
format |
Article in Journal/Newspaper |
author |
Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric |
author_facet |
Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric |
author_sort |
Kombila Maryvonne |
title |
Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon |
title_short |
Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon |
title_full |
Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon |
title_fullStr |
Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon |
title_full_unstemmed |
Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon |
title_sort |
malaria transmission and insecticide resistance of anopheles gambiae in libreville and port-gentil, gabon |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-321 https://doaj.org/article/ad0eee914d8b4fc0bbe37d8b8451b22f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 321 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/321 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-321 1475-2875 https://doaj.org/article/ad0eee914d8b4fc0bbe37d8b8451b22f |
op_doi |
https://doi.org/10.1186/1475-2875-9-321 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
container_start_page |
321 |
_version_ |
1766347131035058176 |