Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats
Wasp venom is mixture of complex proteins that have several physical and pharmacological properties. The photochemical detoxification of Vespa orientalis venom is expected to generate photooxidized venom sac extract (PVSE). Antigenically active PVSE is obtained by exposing the venom sac extract (VSE...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:acc961e2918047cf941591d17fb28dc3 2023-05-15T15:08:43+02:00 Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats H Mukund SP Gawade 2011-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992011000400009 https://doaj.org/article/acc961e2918047cf941591d17fb28dc3 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400009 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000400009 1678-9199 https://doaj.org/article/acc961e2918047cf941591d17fb28dc3 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 4, Pp 422-429 (2011) Vespa venom photochemical processes learning memory maze learning Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2011 ftdoajarticles https://doi.org/10.1590/S1678-91992011000400009 2022-12-31T00:11:44Z Wasp venom is mixture of complex proteins that have several physical and pharmacological properties. The photochemical detoxification of Vespa orientalis venom is expected to generate photooxidized venom sac extract (PVSE). Antigenically active PVSE is obtained by exposing the venom sac extract (VSE) of Vespa orientalis to ultraviolet radiation in the presence of methylene blue. The aim of the present work was to evaluate the effect of PVSE on learning and memory of rats. Detoxification of PVSE was evident since treated mice had longer survival time than the group of mice treated with VSE. Photooxidized VSE of V. orientalis revealed enhancement on learning and memory by shortening the time to reach food (TRF) in T-maze. In a 28-day study with rats, we observed that PVSE significantly decreased transfer latency (TL) in elevated plus maze (EPM), significantly increased step down latency (SDL), diminished step down errors (SDE) and time spent in shock zone (TSS) in step down avoidance test. Thus, we concluded that although there is a possibility of employing PVSE in the treatment of Alzheimer, dementia or neurodegenerative illness as a non-herbal and non-synthetic alternative for patients who do not respond to available therapy, further investigation is still required. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 17 4 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Vespa venom photochemical processes learning memory maze learning Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Vespa venom photochemical processes learning memory maze learning Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 H Mukund SP Gawade Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats |
topic_facet |
Vespa venom photochemical processes learning memory maze learning Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Wasp venom is mixture of complex proteins that have several physical and pharmacological properties. The photochemical detoxification of Vespa orientalis venom is expected to generate photooxidized venom sac extract (PVSE). Antigenically active PVSE is obtained by exposing the venom sac extract (VSE) of Vespa orientalis to ultraviolet radiation in the presence of methylene blue. The aim of the present work was to evaluate the effect of PVSE on learning and memory of rats. Detoxification of PVSE was evident since treated mice had longer survival time than the group of mice treated with VSE. Photooxidized VSE of V. orientalis revealed enhancement on learning and memory by shortening the time to reach food (TRF) in T-maze. In a 28-day study with rats, we observed that PVSE significantly decreased transfer latency (TL) in elevated plus maze (EPM), significantly increased step down latency (SDL), diminished step down errors (SDE) and time spent in shock zone (TSS) in step down avoidance test. Thus, we concluded that although there is a possibility of employing PVSE in the treatment of Alzheimer, dementia or neurodegenerative illness as a non-herbal and non-synthetic alternative for patients who do not respond to available therapy, further investigation is still required. |
format |
Article in Journal/Newspaper |
author |
H Mukund SP Gawade |
author_facet |
H Mukund SP Gawade |
author_sort |
H Mukund |
title |
Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats |
title_short |
Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats |
title_full |
Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats |
title_fullStr |
Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats |
title_full_unstemmed |
Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats |
title_sort |
evaluation of effects of photooxidized vespa orientalis venom on memory and learning in rats |
publisher |
SciELO |
publishDate |
2011 |
url |
https://doi.org/10.1590/S1678-91992011000400009 https://doaj.org/article/acc961e2918047cf941591d17fb28dc3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 4, Pp 422-429 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400009 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000400009 1678-9199 https://doaj.org/article/acc961e2918047cf941591d17fb28dc3 |
op_doi |
https://doi.org/10.1590/S1678-91992011000400009 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
17 |
container_issue |
4 |
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1766340027646738432 |