T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis.
Immunostimulatory therapy is a promising approach to improving the treatment of systemic fungal infections such as paracoccidioidomycosis (PCM), whose drug therapy is usually prolonged and associated with toxic side effects and relapses. The current study was undertaken to determine if the injection...
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ftdoajarticles:oai:doaj.org/article:acb38449c2ce45bdb115c7717a81f5a7 2023-05-15T15:08:48+02:00 T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. Leandro Licursi de Oliveira Kely Cristine Coltri Cristina Ribeiro Barros Cardoso Maria-Cristina Roque-Barreira Ademilson Panunto-Castelo 2008-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000183 https://doaj.org/article/acb38449c2ce45bdb115c7717a81f5a7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2263123?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000183 https://doaj.org/article/acb38449c2ce45bdb115c7717a81f5a7 PLoS Neglected Tropical Diseases, Vol 2, Iss 3, p e183 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000183 2022-12-31T05:28:18Z Immunostimulatory therapy is a promising approach to improving the treatment of systemic fungal infections such as paracoccidioidomycosis (PCM), whose drug therapy is usually prolonged and associated with toxic side effects and relapses. The current study was undertaken to determine if the injection of a T helper (Th) 1-stimulating adjuvant in P. brasiliensis-infected mice could have a beneficial effect on the course of experimental PCM. For this purpose, mice were infected and treated with complete Freund's adjuvant (CFA), a well-established Th1 experimental inductor, or incomplete Freund's adjuvant (IFA - control group) on day 20 postinfection. Four weeks after treatment, the CFA-treated mice presented a mild infection in the lungs characterized by absence of epithelioid cell granulomas and yeast cells, whereas the control mice presented multiple sites of focal epithelioid granulomas with lymphomonocytic halos circumscribing a high number of viable and nonviable yeast cells. In addition, CFA administration induced a 2.4 log reduction (>99%) in the fungal burden when compared to the control group, and led to an improvement of immune response, reversing the immunosuppression observed in the control group. The immunotherapy with Th1-inducing adjuvant, approved to be used in humans, might be a valuable tool in the treatment of PCM and potentially useful to improve the clinical cure rate in humans. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 3 e183 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Leandro Licursi de Oliveira Kely Cristine Coltri Cristina Ribeiro Barros Cardoso Maria-Cristina Roque-Barreira Ademilson Panunto-Castelo T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Immunostimulatory therapy is a promising approach to improving the treatment of systemic fungal infections such as paracoccidioidomycosis (PCM), whose drug therapy is usually prolonged and associated with toxic side effects and relapses. The current study was undertaken to determine if the injection of a T helper (Th) 1-stimulating adjuvant in P. brasiliensis-infected mice could have a beneficial effect on the course of experimental PCM. For this purpose, mice were infected and treated with complete Freund's adjuvant (CFA), a well-established Th1 experimental inductor, or incomplete Freund's adjuvant (IFA - control group) on day 20 postinfection. Four weeks after treatment, the CFA-treated mice presented a mild infection in the lungs characterized by absence of epithelioid cell granulomas and yeast cells, whereas the control mice presented multiple sites of focal epithelioid granulomas with lymphomonocytic halos circumscribing a high number of viable and nonviable yeast cells. In addition, CFA administration induced a 2.4 log reduction (>99%) in the fungal burden when compared to the control group, and led to an improvement of immune response, reversing the immunosuppression observed in the control group. The immunotherapy with Th1-inducing adjuvant, approved to be used in humans, might be a valuable tool in the treatment of PCM and potentially useful to improve the clinical cure rate in humans. |
format |
Article in Journal/Newspaper |
author |
Leandro Licursi de Oliveira Kely Cristine Coltri Cristina Ribeiro Barros Cardoso Maria-Cristina Roque-Barreira Ademilson Panunto-Castelo |
author_facet |
Leandro Licursi de Oliveira Kely Cristine Coltri Cristina Ribeiro Barros Cardoso Maria-Cristina Roque-Barreira Ademilson Panunto-Castelo |
author_sort |
Leandro Licursi de Oliveira |
title |
T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
title_short |
T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
title_full |
T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
title_fullStr |
T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
title_full_unstemmed |
T helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
title_sort |
t helper 1-inducing adjuvant protects against experimental paracoccidioidomycosis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000183 https://doaj.org/article/acb38449c2ce45bdb115c7717a81f5a7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 3, p e183 (2008) |
op_relation |
http://europepmc.org/articles/PMC2263123?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000183 https://doaj.org/article/acb38449c2ce45bdb115c7717a81f5a7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000183 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
2 |
container_issue |
3 |
container_start_page |
e183 |
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1766340091005894656 |