Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.
Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many filarial species settle in the serous cavities including M. perstans in hu...
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ftdoajarticles:oai:doaj.org/article:ac502bbd8a654742b2e1e3a99eaf65ec 2023-05-15T15:07:08+02:00 Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. Gregory Karadjian Frédéric Fercoq Nicolas Pionnier Nathaly Vallarino-Lhermitte Emilie Lefoulon Adélaïde Nieguitsila Sabine Specht Leo M Carlin Coralie Martin 2017-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005596 https://doaj.org/article/ac502bbd8a654742b2e1e3a99eaf65ec EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5438187?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005596 https://doaj.org/article/ac502bbd8a654742b2e1e3a99eaf65ec PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005596 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005596 2022-12-31T00:47:58Z Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many filarial species settle in the serous cavities including M. perstans in humans and L. sigmodontis, a well-established model of filariasis in mice. L. sigmodontis L3 migrate to the pleural cavity where they moult into L4 around day 9 and into male and female adult worms around day 30. Little is known of the early phase of the parasite life cycle, after the L3 is inoculated in the dermis by the vector and enters the afferent lymphatic vessels and before the moulting processes in the pleural cavity. Here we reveal a pulmonary phase associated with lung damage characterized by haemorrhages and granulomas suggesting L3 reach the lung via pulmonary capillaries and damage the endothelium and parenchyma by crossing them to enter the pleural cavity. This study also provides evidence for a transient inflammation in the lung characterized by a very early recruitment of neutrophils associated with high expression levels of S100A8 and S100A9 proteins. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 5 e0005596 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gregory Karadjian Frédéric Fercoq Nicolas Pionnier Nathaly Vallarino-Lhermitte Emilie Lefoulon Adélaïde Nieguitsila Sabine Specht Leo M Carlin Coralie Martin Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many filarial species settle in the serous cavities including M. perstans in humans and L. sigmodontis, a well-established model of filariasis in mice. L. sigmodontis L3 migrate to the pleural cavity where they moult into L4 around day 9 and into male and female adult worms around day 30. Little is known of the early phase of the parasite life cycle, after the L3 is inoculated in the dermis by the vector and enters the afferent lymphatic vessels and before the moulting processes in the pleural cavity. Here we reveal a pulmonary phase associated with lung damage characterized by haemorrhages and granulomas suggesting L3 reach the lung via pulmonary capillaries and damage the endothelium and parenchyma by crossing them to enter the pleural cavity. This study also provides evidence for a transient inflammation in the lung characterized by a very early recruitment of neutrophils associated with high expression levels of S100A8 and S100A9 proteins. |
format |
Article in Journal/Newspaper |
author |
Gregory Karadjian Frédéric Fercoq Nicolas Pionnier Nathaly Vallarino-Lhermitte Emilie Lefoulon Adélaïde Nieguitsila Sabine Specht Leo M Carlin Coralie Martin |
author_facet |
Gregory Karadjian Frédéric Fercoq Nicolas Pionnier Nathaly Vallarino-Lhermitte Emilie Lefoulon Adélaïde Nieguitsila Sabine Specht Leo M Carlin Coralie Martin |
author_sort |
Gregory Karadjian |
title |
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. |
title_short |
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. |
title_full |
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. |
title_fullStr |
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. |
title_full_unstemmed |
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. |
title_sort |
migratory phase of litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of s100a9 expressing neutrophils in the lung. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005596 https://doaj.org/article/ac502bbd8a654742b2e1e3a99eaf65ec |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005596 (2017) |
op_relation |
http://europepmc.org/articles/PMC5438187?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005596 https://doaj.org/article/ac502bbd8a654742b2e1e3a99eaf65ec |
op_doi |
https://doi.org/10.1371/journal.pntd.0005596 |
container_title |
PLOS Neglected Tropical Diseases |
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11 |
container_issue |
5 |
container_start_page |
e0005596 |
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