Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors.
BACKGROUND: Seroprevalence and incidence of toxoplasmosis in women of child bearing age has remained a contentious issue in the Indian subcontinent. Different laboratories have used different patient recruitment criteria, methods and variable results, making these data difficult to compare. AIM: To...
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ftdoajarticles:oai:doaj.org/article:ac43e03e9c5f4a4a9e096f8429eeddd5 2023-05-15T15:17:12+02:00 Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. Sarman Singh Arshi Munawwar Sugandhi Rao Sanjay Mehta Naba Kumar Hazarika 2014-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002737 https://doaj.org/article/ac43e03e9c5f4a4a9e096f8429eeddd5 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3967963?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002737 https://doaj.org/article/ac43e03e9c5f4a4a9e096f8429eeddd5 PLoS Neglected Tropical Diseases, Vol 8, Iss 3, p e2737 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002737 2022-12-31T01:32:59Z BACKGROUND: Seroprevalence and incidence of toxoplasmosis in women of child bearing age has remained a contentious issue in the Indian subcontinent. Different laboratories have used different patient recruitment criteria, methods and variable results, making these data difficult to compare. AIM: To map the point-prevalence and incidence of toxoplasmosis in India. MATERIAL AND METHODS: In this cross-sectional study, a total of 1464 women of fertile age were recruited from 4 regions using similar recruitment plans. This included women from northern (203), southern (512), eastern (250) and western (501) regions of India. All samples were transported to a central laboratory in Delhi and tested using VIDAS technology. Their age, parity, eating habits and other demographic and clinical details were noted. RESULTS: Most women were in the 18-25 years age group (48.3%), followed by 26-30 years (28.2%) and 31-35 years (13.66). Few (45) women older than 35 yr. were included. Overall prevalence of anti-Toxoplasma IgG antibodies was seen in 22.40%, with significantly more in married women (25.8%) as compared to single women (4.3%). Prevalence increased steadily with age: 18.1% in the 18-25 yr. age group to 40.5% in women older than 40 yr. The prevalence was high (66%) in those who resided in mud houses. Region-wise, the highest prevalence was observed in South India (37.3%) and the lowest (8.8%) in West Indian women. This difference was highly significant (P<0.001). Prevalence was 21.2% in East India and 19.7% in North India. The IgM positivity rate ranged from 0.4% to 2.9% in four study centers. CONCLUSIONS: This pan-India study shows a prevalence rate of 22.4% with a wide variation in four geographical regions ranging from as low as 8.8% to as high as 37.3%. The overall IgM positivity rate was 1.43%, indicating that an estimated 56,737-176,882 children per year are born in India with a possible risk of congenital toxoplasmosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian PLoS Neglected Tropical Diseases 8 3 e2737 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sarman Singh Arshi Munawwar Sugandhi Rao Sanjay Mehta Naba Kumar Hazarika Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Seroprevalence and incidence of toxoplasmosis in women of child bearing age has remained a contentious issue in the Indian subcontinent. Different laboratories have used different patient recruitment criteria, methods and variable results, making these data difficult to compare. AIM: To map the point-prevalence and incidence of toxoplasmosis in India. MATERIAL AND METHODS: In this cross-sectional study, a total of 1464 women of fertile age were recruited from 4 regions using similar recruitment plans. This included women from northern (203), southern (512), eastern (250) and western (501) regions of India. All samples were transported to a central laboratory in Delhi and tested using VIDAS technology. Their age, parity, eating habits and other demographic and clinical details were noted. RESULTS: Most women were in the 18-25 years age group (48.3%), followed by 26-30 years (28.2%) and 31-35 years (13.66). Few (45) women older than 35 yr. were included. Overall prevalence of anti-Toxoplasma IgG antibodies was seen in 22.40%, with significantly more in married women (25.8%) as compared to single women (4.3%). Prevalence increased steadily with age: 18.1% in the 18-25 yr. age group to 40.5% in women older than 40 yr. The prevalence was high (66%) in those who resided in mud houses. Region-wise, the highest prevalence was observed in South India (37.3%) and the lowest (8.8%) in West Indian women. This difference was highly significant (P<0.001). Prevalence was 21.2% in East India and 19.7% in North India. The IgM positivity rate ranged from 0.4% to 2.9% in four study centers. CONCLUSIONS: This pan-India study shows a prevalence rate of 22.4% with a wide variation in four geographical regions ranging from as low as 8.8% to as high as 37.3%. The overall IgM positivity rate was 1.43%, indicating that an estimated 56,737-176,882 children per year are born in India with a possible risk of congenital toxoplasmosis. |
format |
Article in Journal/Newspaper |
author |
Sarman Singh Arshi Munawwar Sugandhi Rao Sanjay Mehta Naba Kumar Hazarika |
author_facet |
Sarman Singh Arshi Munawwar Sugandhi Rao Sanjay Mehta Naba Kumar Hazarika |
author_sort |
Sarman Singh |
title |
Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. |
title_short |
Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. |
title_full |
Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. |
title_fullStr |
Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. |
title_full_unstemmed |
Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. |
title_sort |
serologic prevalence of toxoplasma gondii in indian women of child bearing age and effects of social and environmental factors. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002737 https://doaj.org/article/ac43e03e9c5f4a4a9e096f8429eeddd5 |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 3, p e2737 (2014) |
op_relation |
http://europepmc.org/articles/PMC3967963?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002737 https://doaj.org/article/ac43e03e9c5f4a4a9e096f8429eeddd5 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002737 |
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PLoS Neglected Tropical Diseases |
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8 |
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3 |
container_start_page |
e2737 |
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