Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis
Objective: To investigate the effect of Gracilaria fisheri oligosaccharides (GFO) on inflammation and colonic epithelial barrier dysfunction in colitis mice. Methods: The animals were treated by oral gavage with distilled water, 1 000 mg/kg inulin, 100, 500, or 1 000 mg/kg GFO for 14 d, or treated w...
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Wolters Kluwer Medknow Publications
2021
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ftdoajarticles:oai:doaj.org/article:ac3106b2faaf488ab33c2f41132d8039 2023-05-15T15:08:48+02:00 Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis Brenda Siringoringo Nawiya Huipao Chittipong Tipbunjong Jongdee Nopparat Santad Wichienchot Albert M Hutapea Pissared Khuituan 2021-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.326098 https://doaj.org/article/ac3106b2faaf488ab33c2f41132d8039 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2021;volume=11;issue=10;spage=440;epage=449;aulast=Siringoringo https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.326098 https://doaj.org/article/ac3106b2faaf488ab33c2f41132d8039 Asian Pacific Journal of Tropical Biomedicine, Vol 11, Iss 10, Pp 440-449 (2021) ulcerative colitis cytokines gut permeability tight junction red algae gracilaria fisheri mice anti-inflammation colonic epithelial barrier Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2021 ftdoajarticles https://doi.org/10.4103/2221-1691.326098 2022-12-30T20:39:28Z Objective: To investigate the effect of Gracilaria fisheri oligosaccharides (GFO) on inflammation and colonic epithelial barrier dysfunction in colitis mice. Methods: The animals were treated by oral gavage with distilled water, 1 000 mg/kg inulin, 100, 500, or 1 000 mg/kg GFO for 14 d, or treated with 50 mg/kg mesalamine for 5 d after colitis induction (on day 10). Histopathology, inflammatory cytokines, colonic permeability, and tight junction proteins were investigated by hematoxylin and eosin staining, immunohistochemical staining, Ussing chamber technique, and Western blotting assays, respectively. Results: GFO ameliorated histological damage in colitis mice when compared to untreated colitis mice. Treatments with 100, 500, and 1 000 mg/kg GFO reduced TNF-α expression, while IL-1β was significantly reduced in colitis mice treated with 500 and 1 000 mg/kg. Compared to untreated colitis mice, GFO increased transepithelial electrical resistance, reduced fluorescein isothiocyanate-dextran paracellular flux, and modulated tight junction proteins (occludin and claudin 2) in colitis mice. Conclusions: GFO has anti-inflammatory activity and could modulate colonic epithelial barrier dysfunction in acetic acid-induced colitis mice. Furthermore, GFO could modulate the expression of tight junction proteins that play important roles in colonic barrier function. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 11 10 440 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
ulcerative colitis cytokines gut permeability tight junction red algae gracilaria fisheri mice anti-inflammation colonic epithelial barrier Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
ulcerative colitis cytokines gut permeability tight junction red algae gracilaria fisheri mice anti-inflammation colonic epithelial barrier Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Brenda Siringoringo Nawiya Huipao Chittipong Tipbunjong Jongdee Nopparat Santad Wichienchot Albert M Hutapea Pissared Khuituan Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
topic_facet |
ulcerative colitis cytokines gut permeability tight junction red algae gracilaria fisheri mice anti-inflammation colonic epithelial barrier Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the effect of Gracilaria fisheri oligosaccharides (GFO) on inflammation and colonic epithelial barrier dysfunction in colitis mice. Methods: The animals were treated by oral gavage with distilled water, 1 000 mg/kg inulin, 100, 500, or 1 000 mg/kg GFO for 14 d, or treated with 50 mg/kg mesalamine for 5 d after colitis induction (on day 10). Histopathology, inflammatory cytokines, colonic permeability, and tight junction proteins were investigated by hematoxylin and eosin staining, immunohistochemical staining, Ussing chamber technique, and Western blotting assays, respectively. Results: GFO ameliorated histological damage in colitis mice when compared to untreated colitis mice. Treatments with 100, 500, and 1 000 mg/kg GFO reduced TNF-α expression, while IL-1β was significantly reduced in colitis mice treated with 500 and 1 000 mg/kg. Compared to untreated colitis mice, GFO increased transepithelial electrical resistance, reduced fluorescein isothiocyanate-dextran paracellular flux, and modulated tight junction proteins (occludin and claudin 2) in colitis mice. Conclusions: GFO has anti-inflammatory activity and could modulate colonic epithelial barrier dysfunction in acetic acid-induced colitis mice. Furthermore, GFO could modulate the expression of tight junction proteins that play important roles in colonic barrier function. |
format |
Article in Journal/Newspaper |
author |
Brenda Siringoringo Nawiya Huipao Chittipong Tipbunjong Jongdee Nopparat Santad Wichienchot Albert M Hutapea Pissared Khuituan |
author_facet |
Brenda Siringoringo Nawiya Huipao Chittipong Tipbunjong Jongdee Nopparat Santad Wichienchot Albert M Hutapea Pissared Khuituan |
author_sort |
Brenda Siringoringo |
title |
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
title_short |
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
title_full |
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
title_fullStr |
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
title_full_unstemmed |
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
title_sort |
gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2021 |
url |
https://doi.org/10.4103/2221-1691.326098 https://doaj.org/article/ac3106b2faaf488ab33c2f41132d8039 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 11, Iss 10, Pp 440-449 (2021) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2021;volume=11;issue=10;spage=440;epage=449;aulast=Siringoringo https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.326098 https://doaj.org/article/ac3106b2faaf488ab33c2f41132d8039 |
op_doi |
https://doi.org/10.4103/2221-1691.326098 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
11 |
container_issue |
10 |
container_start_page |
440 |
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1766340097806958592 |