The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report.
Chagas disease, caused by Trypanosoma cruzi, affects millions of people globally and is associated with significant underdiagnosis and undertreatment. Current diagnostic algorithms face challenges in remote regions. We aimed to review the potential of rapid diagnostic tests (RDTs) for screening or d...
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ftdoajarticles:oai:doaj.org/article:ac18c3a9eacc4263999fd264ff876d60 2024-09-09T19:25:39+00:00 The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. Freddy Perez Debbie Vermeij Roberto Salvatella Luis Gerardo Castellanos Andrea Silvestre de Sousa 2024-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0012340 https://doaj.org/article/ac18c3a9eacc4263999fd264ff876d60 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0012340 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012340 https://doaj.org/article/ac18c3a9eacc4263999fd264ff876d60 PLoS Neglected Tropical Diseases, Vol 18, Iss 8, p e0012340 (2024) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2024 ftdoajarticles https://doi.org/10.1371/journal.pntd.0012340 2024-08-19T14:56:38Z Chagas disease, caused by Trypanosoma cruzi, affects millions of people globally and is associated with significant underdiagnosis and undertreatment. Current diagnostic algorithms face challenges in remote regions. We aimed to review the potential of rapid diagnostic tests (RDTs) for screening or diagnosing chronic Chagas disease in endemic areas. An expert panel representing scientific and academic institutions from the Americas convened with the aim of discussing the use of RDTs. The study employed the nominal group technique, gathering insights from diverse experts during a 3-day meeting. Panel discussions covered RDT application, research protocols, and regulatory mechanisms. The results indicate that RDTs play a crucial role in surveillance and screening, although limitations in sensitivity and specificity exist. The expert group recommends standardized protocols, emphasizes the importance of cost-effectiveness assessments, and highlights the need to consider geographic validation. Despite these challenges, RDTs present a promising avenue for improving Chagas disease diagnosis in resource-limited settings. Future research and a collaborative approach are deemed essential for effective implementation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 18 8 e0012340 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Freddy Perez Debbie Vermeij Roberto Salvatella Luis Gerardo Castellanos Andrea Silvestre de Sousa The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Chagas disease, caused by Trypanosoma cruzi, affects millions of people globally and is associated with significant underdiagnosis and undertreatment. Current diagnostic algorithms face challenges in remote regions. We aimed to review the potential of rapid diagnostic tests (RDTs) for screening or diagnosing chronic Chagas disease in endemic areas. An expert panel representing scientific and academic institutions from the Americas convened with the aim of discussing the use of RDTs. The study employed the nominal group technique, gathering insights from diverse experts during a 3-day meeting. Panel discussions covered RDT application, research protocols, and regulatory mechanisms. The results indicate that RDTs play a crucial role in surveillance and screening, although limitations in sensitivity and specificity exist. The expert group recommends standardized protocols, emphasizes the importance of cost-effectiveness assessments, and highlights the need to consider geographic validation. Despite these challenges, RDTs present a promising avenue for improving Chagas disease diagnosis in resource-limited settings. Future research and a collaborative approach are deemed essential for effective implementation. |
format |
Article in Journal/Newspaper |
author |
Freddy Perez Debbie Vermeij Roberto Salvatella Luis Gerardo Castellanos Andrea Silvestre de Sousa |
author_facet |
Freddy Perez Debbie Vermeij Roberto Salvatella Luis Gerardo Castellanos Andrea Silvestre de Sousa |
author_sort |
Freddy Perez |
title |
The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. |
title_short |
The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. |
title_full |
The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. |
title_fullStr |
The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. |
title_full_unstemmed |
The use of rapid diagnostic tests for chronic Chagas disease: An expert meeting report. |
title_sort |
use of rapid diagnostic tests for chronic chagas disease: an expert meeting report. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2024 |
url |
https://doi.org/10.1371/journal.pntd.0012340 https://doaj.org/article/ac18c3a9eacc4263999fd264ff876d60 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 18, Iss 8, p e0012340 (2024) |
op_relation |
https://doi.org/10.1371/journal.pntd.0012340 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012340 https://doaj.org/article/ac18c3a9eacc4263999fd264ff876d60 |
op_doi |
https://doi.org/10.1371/journal.pntd.0012340 |
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PLOS Neglected Tropical Diseases |
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18 |
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8 |
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e0012340 |
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