Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review.
BACKGROUND:Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and...
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ftdoajarticles:oai:doaj.org/article:ac0ae7e03da141f0af69969c0ba7161e 2023-05-15T15:10:35+02:00 Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta 2017-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005528 https://doaj.org/article/ac0ae7e03da141f0af69969c0ba7161e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5398716?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005528 https://doaj.org/article/ac0ae7e03da141f0af69969c0ba7161e PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005528 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005528 2022-12-31T00:27:40Z BACKGROUND:Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and the presence of ZIKV infection in breastfeeding-related fluids. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a systematic review of observational studies, case studies, and surveillance reports involving breastfeeding women with ZIKV infection in several international databases. Data extraction and analysis were conducted following a PROSPERO-registered protocol. From 472 non-duplicate records, two case reports met criteria for inclusion. We reviewed three cases of ZIKV infection among lactating mothers near the time of delivery. Two of the three (2/3) associated newborns had evidence of ZIKV infection. ZIKV was detected in breast milk of all three mothers. Breast milk detection results were positive in all mothers (3/3) by RT-PCR, one was positive by culture (1/3), and none was tested for ZIKV-specific antibodies. Serum samples were ZIKV positive in all mothers (3/3), and sweat was not tested for ZIKV. CONCLUSIONS/SIGNIFICANCE:We describe three cases of ZIKV-infected breastfeeding mothers who were symptomatic within three days of delivery, and two cases with ZIKV-infected newborns. While ZIKV was detected in the breast milk of all three mothers, the data are not sufficient to conclude ZIKV transmission via breastfeeding. More evidence is needed to distinguish breastfeeding transmission from other perinatal transmission routes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 4 e0005528 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and the presence of ZIKV infection in breastfeeding-related fluids. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a systematic review of observational studies, case studies, and surveillance reports involving breastfeeding women with ZIKV infection in several international databases. Data extraction and analysis were conducted following a PROSPERO-registered protocol. From 472 non-duplicate records, two case reports met criteria for inclusion. We reviewed three cases of ZIKV infection among lactating mothers near the time of delivery. Two of the three (2/3) associated newborns had evidence of ZIKV infection. ZIKV was detected in breast milk of all three mothers. Breast milk detection results were positive in all mothers (3/3) by RT-PCR, one was positive by culture (1/3), and none was tested for ZIKV-specific antibodies. Serum samples were ZIKV positive in all mothers (3/3), and sweat was not tested for ZIKV. CONCLUSIONS/SIGNIFICANCE:We describe three cases of ZIKV-infected breastfeeding mothers who were symptomatic within three days of delivery, and two cases with ZIKV-infected newborns. While ZIKV was detected in the breast milk of all three mothers, the data are not sufficient to conclude ZIKV transmission via breastfeeding. More evidence is needed to distinguish breastfeeding transmission from other perinatal transmission routes. |
format |
Article in Journal/Newspaper |
author |
Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta |
author_facet |
Susannah Colt Maria N Garcia-Casal Juan Pablo Peña-Rosas Julia L Finkelstein Pura Rayco-Solon Zita C Weise Prinzo Saurabh Mehta |
author_sort |
Susannah Colt |
title |
Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
title_short |
Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
title_full |
Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
title_fullStr |
Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
title_full_unstemmed |
Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review. |
title_sort |
transmission of zika virus through breast milk and other breastfeeding-related bodily-fluids: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005528 https://doaj.org/article/ac0ae7e03da141f0af69969c0ba7161e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005528 (2017) |
op_relation |
http://europepmc.org/articles/PMC5398716?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005528 https://doaj.org/article/ac0ae7e03da141f0af69969c0ba7161e |
op_doi |
https://doi.org/10.1371/journal.pntd.0005528 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
4 |
container_start_page |
e0005528 |
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1766341579677630464 |