Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country.
Background Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Latin...
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ftdoajarticles:oai:doaj.org/article:aba5d83860ac4b1692a80343b3524452 2023-05-15T15:15:02+02:00 Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. Jara Llenas-García Philip Wikman-Jorgensen Concepción Gil-Anguita Violeta Ramos-Sesma Diego Torrús-Tendero Raquel Martínez-Goñi Mónica Romero-Nieto Javier García-Abellán María José Esteban-Giner Karenina Antelo María Navarro-Cots Fernando Buñuel Concepción Amador Josefa García-García Isabel Gascón Guillermo Telenti Encarna Fuentes-Campos Ignacio Torres Adelina Gimeno-Gascón María Montserrat Ruíz-García Miriam Navarro José-Manuel Ramos-Rincón 2021-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009281 https://doaj.org/article/aba5d83860ac4b1692a80343b3524452 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009281 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009281 https://doaj.org/article/aba5d83860ac4b1692a80343b3524452 PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009281 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009281 2022-12-31T11:41:09Z Background Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Latin American women in the province of Alicante from 2014 to 2018. Methodology/principal findings Retrospective quality study using two data sources: 1) delivery records of Latin American women that gave birth in the 10 public hospitals of Alicante between January 2014 and December 2018; and 2) records of Chagas serologies carried out in those centers between May 2013 and December 2018. There were 3026 deliveries in Latin American women during the study period; 1178 (38.9%) underwent CD serology. Screening adherence ranged from 17.2% to 59.3% in the different health departments and was higher in Bolivian women (48.3%). Twenty-six deliveries (2.2%) had a positive screening; CD was confirmed in 23 (2%) deliveries of 21 women. Bolivians had the highest seroprevalence (21/112; 18.7%), followed by Colombians (1/333; 0.3%) and Ecuadorians (1/348; 0.3%). Of 21 CD-positive women (19 Bolivians, 1 Colombian, 1 Ecuadorian), infection was already known in 12 (57.1%), and 9 (42.9%) had already been treated. Only 1 of the 12 untreated women (8.3%) was treated postpartum. Follow-up started in 20 of the 23 (87.0%) neonates but was completed only in 11 (47.8%); no cases of congenital transmission were detected. Among the 1848 unscreened deliveries, we estimate 43 undiagnosed cases of CD and 1 to 2 undetected cases of congenital transmission. Conclusions/significance Adherence to recommendations of systematic screening for CD in Latin American pregnant women in Alicante can be improved. Strategies to strengthen treatment of postpartum women and monitoring of exposed newborns are needed. Currently, there may be undetected cases of congenital transmission in our province. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 3 e0009281 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jara Llenas-García Philip Wikman-Jorgensen Concepción Gil-Anguita Violeta Ramos-Sesma Diego Torrús-Tendero Raquel Martínez-Goñi Mónica Romero-Nieto Javier García-Abellán María José Esteban-Giner Karenina Antelo María Navarro-Cots Fernando Buñuel Concepción Amador Josefa García-García Isabel Gascón Guillermo Telenti Encarna Fuentes-Campos Ignacio Torres Adelina Gimeno-Gascón María Montserrat Ruíz-García Miriam Navarro José-Manuel Ramos-Rincón Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Latin American women in the province of Alicante from 2014 to 2018. Methodology/principal findings Retrospective quality study using two data sources: 1) delivery records of Latin American women that gave birth in the 10 public hospitals of Alicante between January 2014 and December 2018; and 2) records of Chagas serologies carried out in those centers between May 2013 and December 2018. There were 3026 deliveries in Latin American women during the study period; 1178 (38.9%) underwent CD serology. Screening adherence ranged from 17.2% to 59.3% in the different health departments and was higher in Bolivian women (48.3%). Twenty-six deliveries (2.2%) had a positive screening; CD was confirmed in 23 (2%) deliveries of 21 women. Bolivians had the highest seroprevalence (21/112; 18.7%), followed by Colombians (1/333; 0.3%) and Ecuadorians (1/348; 0.3%). Of 21 CD-positive women (19 Bolivians, 1 Colombian, 1 Ecuadorian), infection was already known in 12 (57.1%), and 9 (42.9%) had already been treated. Only 1 of the 12 untreated women (8.3%) was treated postpartum. Follow-up started in 20 of the 23 (87.0%) neonates but was completed only in 11 (47.8%); no cases of congenital transmission were detected. Among the 1848 unscreened deliveries, we estimate 43 undiagnosed cases of CD and 1 to 2 undetected cases of congenital transmission. Conclusions/significance Adherence to recommendations of systematic screening for CD in Latin American pregnant women in Alicante can be improved. Strategies to strengthen treatment of postpartum women and monitoring of exposed newborns are needed. Currently, there may be undetected cases of congenital transmission in our province. |
format |
Article in Journal/Newspaper |
author |
Jara Llenas-García Philip Wikman-Jorgensen Concepción Gil-Anguita Violeta Ramos-Sesma Diego Torrús-Tendero Raquel Martínez-Goñi Mónica Romero-Nieto Javier García-Abellán María José Esteban-Giner Karenina Antelo María Navarro-Cots Fernando Buñuel Concepción Amador Josefa García-García Isabel Gascón Guillermo Telenti Encarna Fuentes-Campos Ignacio Torres Adelina Gimeno-Gascón María Montserrat Ruíz-García Miriam Navarro José-Manuel Ramos-Rincón |
author_facet |
Jara Llenas-García Philip Wikman-Jorgensen Concepción Gil-Anguita Violeta Ramos-Sesma Diego Torrús-Tendero Raquel Martínez-Goñi Mónica Romero-Nieto Javier García-Abellán María José Esteban-Giner Karenina Antelo María Navarro-Cots Fernando Buñuel Concepción Amador Josefa García-García Isabel Gascón Guillermo Telenti Encarna Fuentes-Campos Ignacio Torres Adelina Gimeno-Gascón María Montserrat Ruíz-García Miriam Navarro José-Manuel Ramos-Rincón |
author_sort |
Jara Llenas-García |
title |
Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. |
title_short |
Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. |
title_full |
Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. |
title_fullStr |
Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. |
title_full_unstemmed |
Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country. |
title_sort |
chagas disease screening in pregnant latin american women: adherence to a systematic screening protocol in a non-endemic country. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009281 https://doaj.org/article/aba5d83860ac4b1692a80343b3524452 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009281 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009281 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009281 https://doaj.org/article/aba5d83860ac4b1692a80343b3524452 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009281 |
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PLOS Neglected Tropical Diseases |
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15 |
container_issue |
3 |
container_start_page |
e0009281 |
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