Major histocompatibility complex in Osteichthyes

• Published in: Journal of Veterinary Research
• Main Authors: Stosik Michał, Tokarz-Deptuła Beata, Deptuła Wiesław
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sciendo 2020
• Subjects: osteichthyes; major histocompatibility complex; Veterinary medicine; SF600-1100; Gar’; Atlantic salmon; Salmo salar
• Online Access: https://doi.org/10.2478/jvetres-2020-0025; https://doaj.org/article/ab892f51e2274ec890b96bd773726180

Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (Lepisosteus oculatus). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, i.e. in paddlefish, sturgeons and spotted gar (Lepisosteus oculatus), as well as in cyprinids (Cyprinidae), Atlantic salmon (Salmo salar), and rainbow trout (Oncorhynchus mykiss). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.