Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin
Abstract Background Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased inciden...
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Online Access: | https://doi.org/10.1186/s12936-019-2656-7 https://doaj.org/article/ab7e3a67ca61463288e9a2099c1d9e4d |
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ftdoajarticles:oai:doaj.org/article:ab7e3a67ca61463288e9a2099c1d9e4d 2023-05-15T15:14:37+02:00 Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin Filémon T. Tokponnon Yolande Sissinto Aurore Hounto Ogouyémi Adicath Adéola Adéothy Alioun Adechoubou Télesphore Houansou Mariam Oke Dorothée Kinde-Gazard Achille Massougbodji Martin C. Akogbeto Sylvie Cornelie Vincent Corbel Tessa B. Knox Abraham Peter Mnzava Martin J. Donnelly Immo Kleinschmidt John Bradley 2019-02-01T00:00:00Z https://doi.org/10.1186/s12936-019-2656-7 https://doaj.org/article/ab7e3a67ca61463288e9a2099c1d9e4d EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2656-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2656-7 1475-2875 https://doaj.org/article/ab7e3a67ca61463288e9a2099c1d9e4d Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) Malaria Insecticide Pyrethroid Resistance Vector Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2656-7 2022-12-30T22:19:49Z Abstract Background Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria. Methods In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old. Results There was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777). Conclusions This study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa’s unacceptably high malaria burden. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Malaria Insecticide Pyrethroid Resistance Vector Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Insecticide Pyrethroid Resistance Vector Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Filémon T. Tokponnon Yolande Sissinto Aurore Hounto Ogouyémi Adicath Adéola Adéothy Alioun Adechoubou Télesphore Houansou Mariam Oke Dorothée Kinde-Gazard Achille Massougbodji Martin C. Akogbeto Sylvie Cornelie Vincent Corbel Tessa B. Knox Abraham Peter Mnzava Martin J. Donnelly Immo Kleinschmidt John Bradley Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin |
topic_facet |
Malaria Insecticide Pyrethroid Resistance Vector Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria. Methods In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old. Results There was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777). Conclusions This study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa’s unacceptably high malaria burden. |
format |
Article in Journal/Newspaper |
author |
Filémon T. Tokponnon Yolande Sissinto Aurore Hounto Ogouyémi Adicath Adéola Adéothy Alioun Adechoubou Télesphore Houansou Mariam Oke Dorothée Kinde-Gazard Achille Massougbodji Martin C. Akogbeto Sylvie Cornelie Vincent Corbel Tessa B. Knox Abraham Peter Mnzava Martin J. Donnelly Immo Kleinschmidt John Bradley |
author_facet |
Filémon T. Tokponnon Yolande Sissinto Aurore Hounto Ogouyémi Adicath Adéola Adéothy Alioun Adechoubou Télesphore Houansou Mariam Oke Dorothée Kinde-Gazard Achille Massougbodji Martin C. Akogbeto Sylvie Cornelie Vincent Corbel Tessa B. Knox Abraham Peter Mnzava Martin J. Donnelly Immo Kleinschmidt John Bradley |
author_sort |
Filémon T. Tokponnon |
title |
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin |
title_short |
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin |
title_full |
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin |
title_fullStr |
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin |
title_full_unstemmed |
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin |
title_sort |
implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from benin |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2656-7 https://doaj.org/article/ab7e3a67ca61463288e9a2099c1d9e4d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2656-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2656-7 1475-2875 https://doaj.org/article/ab7e3a67ca61463288e9a2099c1d9e4d |
op_doi |
https://doi.org/10.1186/s12936-019-2656-7 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766345045855698944 |