Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini.
The two parasitic trematodes, Clonorchis sinensis and Opisthorchis viverrini, have a major impact on the health of tens of millions of humans throughout Asia. The greatest impact is through the malignant cancer ( = cholangiocarcinoma) that these parasites induce in chronically infected people. There...
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ftdoajarticles:oai:doaj.org/article:aaf624f038e242699a4eb2260d6f399a 2023-05-15T15:09:54+02:00 Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. Neil D Young Bronwyn E Campbell Ross S Hall Aaron R Jex Cinzia Cantacessi Thewarach Laha Woon-Mok Sohn Banchob Sripa Alex Loukas Paul J Brindley Robin B Gasser 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000719 https://doaj.org/article/aaf624f038e242699a4eb2260d6f399a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2889816?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0000719 1935-2727 1935-2735 https://doaj.org/article/aaf624f038e242699a4eb2260d6f399a PLoS Neglected Tropical Diseases, Vol 4, Iss 6, p e719 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000719 2022-12-31T01:16:43Z The two parasitic trematodes, Clonorchis sinensis and Opisthorchis viverrini, have a major impact on the health of tens of millions of humans throughout Asia. The greatest impact is through the malignant cancer ( = cholangiocarcinoma) that these parasites induce in chronically infected people. Therefore, both C. sinensis and O. viverrini have been classified by the World Health Organization (WHO) as Group 1 carcinogens. Despite their impact, little is known about these parasites and their interplay with the host at the molecular level. Recent advances in genomics and bioinformatics provide unique opportunities to gain improved insights into the biology of parasites as well as their relationships with their hosts at the molecular level. The present study elucidates the transcriptomes of C. sinensis and O. viverrini using a platform based on next-generation (high throughput) sequencing and advanced in silico analyses. From 500,000 sequences, >50,000 sequences were assembled for each species and categorized as biologically relevant based on homology searches, gene ontology and/or pathway mapping. The results of the present study could assist in defining molecules that are essential for the development, reproduction and survival of liver flukes and/or that are linked to the development of cholangiocarcinoma. This study also lays a foundation for future genomic and proteomic research of C. sinensis and O. viverrini and the cancers that they are known to induce, as well as novel intervention strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 6 e719 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Neil D Young Bronwyn E Campbell Ross S Hall Aaron R Jex Cinzia Cantacessi Thewarach Laha Woon-Mok Sohn Banchob Sripa Alex Loukas Paul J Brindley Robin B Gasser Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The two parasitic trematodes, Clonorchis sinensis and Opisthorchis viverrini, have a major impact on the health of tens of millions of humans throughout Asia. The greatest impact is through the malignant cancer ( = cholangiocarcinoma) that these parasites induce in chronically infected people. Therefore, both C. sinensis and O. viverrini have been classified by the World Health Organization (WHO) as Group 1 carcinogens. Despite their impact, little is known about these parasites and their interplay with the host at the molecular level. Recent advances in genomics and bioinformatics provide unique opportunities to gain improved insights into the biology of parasites as well as their relationships with their hosts at the molecular level. The present study elucidates the transcriptomes of C. sinensis and O. viverrini using a platform based on next-generation (high throughput) sequencing and advanced in silico analyses. From 500,000 sequences, >50,000 sequences were assembled for each species and categorized as biologically relevant based on homology searches, gene ontology and/or pathway mapping. The results of the present study could assist in defining molecules that are essential for the development, reproduction and survival of liver flukes and/or that are linked to the development of cholangiocarcinoma. This study also lays a foundation for future genomic and proteomic research of C. sinensis and O. viverrini and the cancers that they are known to induce, as well as novel intervention strategies. |
format |
Article in Journal/Newspaper |
author |
Neil D Young Bronwyn E Campbell Ross S Hall Aaron R Jex Cinzia Cantacessi Thewarach Laha Woon-Mok Sohn Banchob Sripa Alex Loukas Paul J Brindley Robin B Gasser |
author_facet |
Neil D Young Bronwyn E Campbell Ross S Hall Aaron R Jex Cinzia Cantacessi Thewarach Laha Woon-Mok Sohn Banchob Sripa Alex Loukas Paul J Brindley Robin B Gasser |
author_sort |
Neil D Young |
title |
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. |
title_short |
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. |
title_full |
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. |
title_fullStr |
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. |
title_full_unstemmed |
Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. |
title_sort |
unlocking the transcriptomes of two carcinogenic parasites, clonorchis sinensis and opisthorchis viverrini. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000719 https://doaj.org/article/aaf624f038e242699a4eb2260d6f399a |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 6, p e719 (2010) |
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http://europepmc.org/articles/PMC2889816?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0000719 1935-2727 1935-2735 https://doaj.org/article/aaf624f038e242699a4eb2260d6f399a |
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https://doi.org/10.1371/journal.pntd.0000719 |
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PLoS Neglected Tropical Diseases |
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6 |
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e719 |
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