Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts
Abstract In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, t...
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ftdoajarticles:oai:doaj.org/article:aad22815c579481d87ece012754c250b 2023-05-15T15:03:14+02:00 Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts Deharo Eric Ginsburg Hagai 2011-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-S1-S5 https://doaj.org/article/aad22815c579481d87ece012754c250b EN eng BMC http://www.malariajournal.com/content/10/S1/S5 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-S1-S5 1475-2875 https://doaj.org/article/aad22815c579481d87ece012754c250b Malaria Journal, Vol 10, Iss Suppl 1, p S5 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-S1-S5 2022-12-31T08:19:24Z Abstract In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, the literature in this field was scanned and results were analysed quantitatively to find the contribution of the pure compound to the activity of the whole extract. It was found that, generally, the activity of isolated molecules could not account on their own for the activity of the crude extract. It is suggested that future research should take into account the “drugs beside the drug”, looking for those products (otherwise discarded along the fractionation process) able to boost the activity of isolated active compounds. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 S1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Deharo Eric Ginsburg Hagai Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, the literature in this field was scanned and results were analysed quantitatively to find the contribution of the pure compound to the activity of the whole extract. It was found that, generally, the activity of isolated molecules could not account on their own for the activity of the crude extract. It is suggested that future research should take into account the “drugs beside the drug”, looking for those products (otherwise discarded along the fractionation process) able to boost the activity of isolated active compounds. |
format |
Article in Journal/Newspaper |
author |
Deharo Eric Ginsburg Hagai |
author_facet |
Deharo Eric Ginsburg Hagai |
author_sort |
Deharo Eric |
title |
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
title_short |
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
title_full |
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
title_fullStr |
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
title_full_unstemmed |
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
title_sort |
analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-S1-S5 https://doaj.org/article/aad22815c579481d87ece012754c250b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss Suppl 1, p S5 (2011) |
op_relation |
http://www.malariajournal.com/content/10/S1/S5 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-S1-S5 1475-2875 https://doaj.org/article/aad22815c579481d87ece012754c250b |
op_doi |
https://doi.org/10.1186/1475-2875-10-S1-S5 |
container_title |
Malaria Journal |
container_volume |
10 |
container_issue |
S1 |
_version_ |
1766335112101756928 |