A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Tanja K Kiener, Qiang Jia, Tao Meng, Vincent Tak Kwong Chow, Jimmy Kwang
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; The Knob
• Online Access: https://doi.org/10.1371/journal.pntd.0002895; https://doaj.org/article/aaa8503ba34c4c82b5a3af5fb8bf5d12

Hand, foot and mouth disease caused by enterovirus 71(EV71) leads to the majority of neurological complications and death in young children. While putative inactivated vaccines are only now undergoing clinical trials, no specific treatment options exist yet. Ideally, EV71 specific intravenous immuno...