Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia
Phylogeographic studies showed that house mice (Mus musculus) originated in the Himalayan region, while common rats (Rattus rattus and Rattus norvegicus) come from the lowlands of China and India. Accordingly, it has been proposed that its origins gave mice, but not rats, the ability to invade ecolo...
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ftdoajarticles:oai:doaj.org/article:aaa69681c6ee4eb6a2f71470ac527c20 2023-05-15T18:05:29+02:00 Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia Christian Arias-Reyes Jorge Soliz Vincent Joseph 2021-03-01T00:00:00Z https://doi.org/10.3389/fphys.2021.647822 https://doaj.org/article/aaa69681c6ee4eb6a2f71470ac527c20 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fphys.2021.647822/full https://doaj.org/toc/1664-042X 1664-042X doi:10.3389/fphys.2021.647822 https://doaj.org/article/aaa69681c6ee4eb6a2f71470ac527c20 Frontiers in Physiology, Vol 12 (2021) acclimatization to hypoxia physiology metabolism mitochondria rodents QP1-981 article 2021 ftdoajarticles https://doi.org/10.3389/fphys.2021.647822 2022-12-31T04:40:45Z Phylogeographic studies showed that house mice (Mus musculus) originated in the Himalayan region, while common rats (Rattus rattus and Rattus norvegicus) come from the lowlands of China and India. Accordingly, it has been proposed that its origins gave mice, but not rats, the ability to invade ecological niches at high altitudes (pre-adaptation). This proposal is strongly supported by the fact that house mice are distributed throughout the world, while common rats are practically absent above 2,500 m. Considering that the ability of mammals to colonize high-altitude environments (>2,500 m) is limited by their capability to tolerate reduced oxygen availability, in this work, we hypothesize that divergences in the ventilatory, hematological, and metabolic phenotypes of mice and rats establish during the process of acclimatization to hypoxia (Hx). To test this hypothesis male FVB mice and Sprague-Dawley (SD) rats were exposed to Hx (12% O2) for 0 h (normoxic controls), 6 h, 1, 7, and 21 days. We assessed changes in ventilatory [minute ventilation (VE), respiratory frequency (fR), and tidal volume (VT)], hematological (hematocrit and hemoglobin concentration), and metabolic [whole-body O2 consumption (VO2) and CO2 production (VCO2), and liver mitochondrial oxygen consumption rate (OCR) parameters]. Compared to rats, results in mice show increased ventilatory, metabolic, and mitochondrial response. In contrast, rats showed quicker and higher hematological response than mice and only minor ventilatory and metabolic adjustments. Our findings may explain, at least in part, why mice, but not rats, were able to colonize high-altitude habitats. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles Frontiers in Physiology 12 |
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acclimatization to hypoxia physiology metabolism mitochondria rodents QP1-981 |
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acclimatization to hypoxia physiology metabolism mitochondria rodents QP1-981 Christian Arias-Reyes Jorge Soliz Vincent Joseph Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia |
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acclimatization to hypoxia physiology metabolism mitochondria rodents QP1-981 |
description |
Phylogeographic studies showed that house mice (Mus musculus) originated in the Himalayan region, while common rats (Rattus rattus and Rattus norvegicus) come from the lowlands of China and India. Accordingly, it has been proposed that its origins gave mice, but not rats, the ability to invade ecological niches at high altitudes (pre-adaptation). This proposal is strongly supported by the fact that house mice are distributed throughout the world, while common rats are practically absent above 2,500 m. Considering that the ability of mammals to colonize high-altitude environments (>2,500 m) is limited by their capability to tolerate reduced oxygen availability, in this work, we hypothesize that divergences in the ventilatory, hematological, and metabolic phenotypes of mice and rats establish during the process of acclimatization to hypoxia (Hx). To test this hypothesis male FVB mice and Sprague-Dawley (SD) rats were exposed to Hx (12% O2) for 0 h (normoxic controls), 6 h, 1, 7, and 21 days. We assessed changes in ventilatory [minute ventilation (VE), respiratory frequency (fR), and tidal volume (VT)], hematological (hematocrit and hemoglobin concentration), and metabolic [whole-body O2 consumption (VO2) and CO2 production (VCO2), and liver mitochondrial oxygen consumption rate (OCR) parameters]. Compared to rats, results in mice show increased ventilatory, metabolic, and mitochondrial response. In contrast, rats showed quicker and higher hematological response than mice and only minor ventilatory and metabolic adjustments. Our findings may explain, at least in part, why mice, but not rats, were able to colonize high-altitude habitats. |
format |
Article in Journal/Newspaper |
author |
Christian Arias-Reyes Jorge Soliz Vincent Joseph |
author_facet |
Christian Arias-Reyes Jorge Soliz Vincent Joseph |
author_sort |
Christian Arias-Reyes |
title |
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia |
title_short |
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia |
title_full |
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia |
title_fullStr |
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia |
title_full_unstemmed |
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia |
title_sort |
mice and rats display different ventilatory, hematological, and metabolic features of acclimatization to hypoxia |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doi.org/10.3389/fphys.2021.647822 https://doaj.org/article/aaa69681c6ee4eb6a2f71470ac527c20 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Frontiers in Physiology, Vol 12 (2021) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fphys.2021.647822/full https://doaj.org/toc/1664-042X 1664-042X doi:10.3389/fphys.2021.647822 https://doaj.org/article/aaa69681c6ee4eb6a2f71470ac527c20 |
op_doi |
https://doi.org/10.3389/fphys.2021.647822 |
container_title |
Frontiers in Physiology |
container_volume |
12 |
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1766176957972611072 |