Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria
Abstract New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase...
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ftdoajarticles:oai:doaj.org/article:aa8005da74504415be18a0657e96f111 2023-05-15T15:03:11+02:00 Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria McKenzie F Ellis Hall B Fenton O'Meara Wendy 2007-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-36 https://doaj.org/article/aa8005da74504415be18a0657e96f111 EN eng BMC http://www.malariajournal.com/content/6/1/36 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-36 1475-2875 https://doaj.org/article/aa8005da74504415be18a0657e96f111 Malaria Journal, Vol 6, Iss 1, p 36 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-36 2022-12-30T21:42:01Z Abstract New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase I and II clinical trials, and several others are poised to begin trials soon. Some studies have been promising, and others disappointing. It is difficult to compare the results of these clinical trials; even independent trials of the same vaccine give highly discrepant results. One major obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 McKenzie F Ellis Hall B Fenton O'Meara Wendy Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase I and II clinical trials, and several others are poised to begin trials soon. Some studies have been promising, and others disappointing. It is difficult to compare the results of these clinical trials; even independent trials of the same vaccine give highly discrepant results. One major obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials. |
format |
Article in Journal/Newspaper |
author |
McKenzie F Ellis Hall B Fenton O'Meara Wendy |
author_facet |
McKenzie F Ellis Hall B Fenton O'Meara Wendy |
author_sort |
McKenzie F Ellis |
title |
Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
title_short |
Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
title_full |
Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
title_fullStr |
Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
title_full_unstemmed |
Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
title_sort |
malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-36 https://doaj.org/article/aa8005da74504415be18a0657e96f111 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 36 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/36 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-36 1475-2875 https://doaj.org/article/aa8005da74504415be18a0657e96f111 |
op_doi |
https://doi.org/10.1186/1475-2875-6-36 |
container_title |
Malaria Journal |
container_volume |
6 |
container_issue |
1 |
_version_ |
1766335070058053632 |