A systematic review of transfusion-transmitted malaria in non-endemic areas
Abstract Background Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient’s bloodstream triggerin...
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ftdoajarticles:oai:doaj.org/article:aa62acaf082a43cfb6b612f4407ce1a1 2023-05-15T15:14:26+02:00 A systematic review of transfusion-transmitted malaria in non-endemic areas Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi 2018-01-01T00:00:00Z https://doi.org/10.1186/s12936-018-2181-0 https://doaj.org/article/aa62acaf082a43cfb6b612f4407ce1a1 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2181-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2181-0 1475-2875 https://doaj.org/article/aa62acaf082a43cfb6b612f4407ce1a1 Malaria Journal, Vol 17, Iss 1, Pp 1-14 (2018) Blood transfusion Malaria Plasmodium Blood component transfusion Transfusion-transmitted malaria (TTM) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2181-0 2022-12-31T01:30:35Z Abstract Background Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient’s bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients. Methods Relevant articles were retrieved from Pubmed, EMBASE, Scopus, and LILACS. From each selected study the following data were extracted: study area, gender and age of blood donor and recipient, blood component associated with TTM, Plasmodium species, malaria diagnostic method employed, blood donor screening method, incubation period between the infected transfusion and the onset of clinical symptoms in the recipient, time elapsed between the clinical symptoms and the diagnosis of malaria, infection outcome, country of origin of the blood donor and time of the last potential malaria exposure. Results Plasmodium species were detected in 100 TTM case reports with a different frequency: 45% Plasmodium falciparum, 30% Plasmodium malariae, 16% Plasmodium vivax, 4% Plasmodium ovale, 2% Plasmodium knowlesi, 1% mixed infection P. falciparum/P. malariae. The majority of fatal outcomes (11/45) was caused by P. falciparum whilst the other fatalities occurred in individuals infected by P. malariae (2/30) and P. ovale (1/4). However, non P. falciparum fatalities were not attributed directly to malaria. The incubation time for all Plasmodium species TTM case reports was longer than what expected in natural infections. This difference was statistically significant for P. malariae (p = 0.006). A longer incubation time in the recipient together with a chronic infection at low parasite density of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Blood transfusion Malaria Plasmodium Blood component transfusion Transfusion-transmitted malaria (TTM) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Blood transfusion Malaria Plasmodium Blood component transfusion Transfusion-transmitted malaria (TTM) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi A systematic review of transfusion-transmitted malaria in non-endemic areas |
topic_facet |
Blood transfusion Malaria Plasmodium Blood component transfusion Transfusion-transmitted malaria (TTM) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient’s bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients. Methods Relevant articles were retrieved from Pubmed, EMBASE, Scopus, and LILACS. From each selected study the following data were extracted: study area, gender and age of blood donor and recipient, blood component associated with TTM, Plasmodium species, malaria diagnostic method employed, blood donor screening method, incubation period between the infected transfusion and the onset of clinical symptoms in the recipient, time elapsed between the clinical symptoms and the diagnosis of malaria, infection outcome, country of origin of the blood donor and time of the last potential malaria exposure. Results Plasmodium species were detected in 100 TTM case reports with a different frequency: 45% Plasmodium falciparum, 30% Plasmodium malariae, 16% Plasmodium vivax, 4% Plasmodium ovale, 2% Plasmodium knowlesi, 1% mixed infection P. falciparum/P. malariae. The majority of fatal outcomes (11/45) was caused by P. falciparum whilst the other fatalities occurred in individuals infected by P. malariae (2/30) and P. ovale (1/4). However, non P. falciparum fatalities were not attributed directly to malaria. The incubation time for all Plasmodium species TTM case reports was longer than what expected in natural infections. This difference was statistically significant for P. malariae (p = 0.006). A longer incubation time in the recipient together with a chronic infection at low parasite density of ... |
format |
Article in Journal/Newspaper |
author |
Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi |
author_facet |
Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi |
author_sort |
Federica Verra |
title |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_short |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_full |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_fullStr |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_full_unstemmed |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_sort |
systematic review of transfusion-transmitted malaria in non-endemic areas |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2181-0 https://doaj.org/article/aa62acaf082a43cfb6b612f4407ce1a1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-14 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2181-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2181-0 1475-2875 https://doaj.org/article/aa62acaf082a43cfb6b612f4407ce1a1 |
op_doi |
https://doi.org/10.1186/s12936-018-2181-0 |
container_title |
Malaria Journal |
container_volume |
17 |
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1 |
_version_ |
1766344883594854400 |