ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS
Elevated lipoprotein(a) plasma concentration - [Lp(a)] is considered a risk factor for cardiovascular disease (CVD). In African Americans (AA) have 2-3 times above [Lp(a)] than in Europeans and Asians, for example, in Chinese - 7.0 mg/dl, in black Sudanese - 46 mg/dl. Some authors believe that the a...
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2018
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ftdoajarticles:oai:doaj.org/article:aa0883b3e11d47eda3729b3579a91fc4 2023-05-15T15:54:33+02:00 ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS I. N. Grigorieva Yu. I. Ragino T. I. Romanova 2018-03-01T00:00:00Z https://doi.org/10.15372/ATER20180106 https://doaj.org/article/aa0883b3e11d47eda3729b3579a91fc4 RU rus Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics https://ateroskleroz.elpub.ru/jour/article/view/66/66 https://doaj.org/toc/2078-256X https://doi.org/10.15372/ATER20180106 2078-256X https://doaj.org/article/aa0883b3e11d47eda3729b3579a91fc4 Атеросклероз, Vol 14, Iss 1, Pp 43-49 (2018) lipoprotein(a) apolipoprotein(a) cardiovascular risk african-americans europeans asians aboriginals of chukotka Diseases of the blood and blood-forming organs RC633-647.5 Diseases of the circulatory (Cardiovascular) system RC666-701 article 2018 ftdoajarticles https://doi.org/10.15372/ATER20180106 2022-12-30T20:54:30Z Elevated lipoprotein(a) plasma concentration - [Lp(a)] is considered a risk factor for cardiovascular disease (CVD). In African Americans (AA) have 2-3 times above [Lp(a)] than in Europeans and Asians, for example, in Chinese - 7.0 mg/dl, in black Sudanese - 46 mg/dl. Some authors believe that the apo(a) gene is the main determinant of the [Lp(a)] variation in AA, while others recognize the role of variant factors. The relationship between [Lp(a)] and the risk of CVD in AA is unclear: in meta-analysis under the Collaboration Emerging Risk Factors, at Europeans [Lp(a)] is associated with coronary artery disease, in AA - no. In Novosibirsk, from 96 men with confirmed surgically expressed coronary atherosclerosis [Lp(a)] is raised only in 16 %, and the high-atherogenous phenotype of apo(a) was detected in 20 %; but in the presence of unstable plaques (UP) in coronary arteries [Lp(a)] is 1.8 times higher than in persons without UP. Average [Lp(a)]+ ([Лп(а)]>0) at Chukchi male made 28,1 mg/dl, Chukchi female have 28,4 mg/dl, at Eskimos with [Lp(a)]+ the median of the [Lp(a)] - 22,4 mg/dl, and the mode - 15,5 mg/dl. In the aboriginals of Chukotka with AH, apo(a) S1, S2 occurred a little more frequently than among those without AH. Along with lipoprotein apheresis and niacin, apolipoprotein-(B-100)-antisense mipomersen, inhibitor of PCSK9 and apolipoprotein-(a)-antisense (oligonucleotide), showed promising results in reducing [Lp(a)]. In Russia, ehvolocumab and alirocoumab have been approved. Article in Journal/Newspaper Chukchi Chukotka eskimo* Directory of Open Access Journals: DOAJ Articles Атеросклероз 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
Russian |
topic |
lipoprotein(a) apolipoprotein(a) cardiovascular risk african-americans europeans asians aboriginals of chukotka Diseases of the blood and blood-forming organs RC633-647.5 Diseases of the circulatory (Cardiovascular) system RC666-701 |
spellingShingle |
lipoprotein(a) apolipoprotein(a) cardiovascular risk african-americans europeans asians aboriginals of chukotka Diseases of the blood and blood-forming organs RC633-647.5 Diseases of the circulatory (Cardiovascular) system RC666-701 I. N. Grigorieva Yu. I. Ragino T. I. Romanova ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS |
topic_facet |
lipoprotein(a) apolipoprotein(a) cardiovascular risk african-americans europeans asians aboriginals of chukotka Diseases of the blood and blood-forming organs RC633-647.5 Diseases of the circulatory (Cardiovascular) system RC666-701 |
description |
Elevated lipoprotein(a) plasma concentration - [Lp(a)] is considered a risk factor for cardiovascular disease (CVD). In African Americans (AA) have 2-3 times above [Lp(a)] than in Europeans and Asians, for example, in Chinese - 7.0 mg/dl, in black Sudanese - 46 mg/dl. Some authors believe that the apo(a) gene is the main determinant of the [Lp(a)] variation in AA, while others recognize the role of variant factors. The relationship between [Lp(a)] and the risk of CVD in AA is unclear: in meta-analysis under the Collaboration Emerging Risk Factors, at Europeans [Lp(a)] is associated with coronary artery disease, in AA - no. In Novosibirsk, from 96 men with confirmed surgically expressed coronary atherosclerosis [Lp(a)] is raised only in 16 %, and the high-atherogenous phenotype of apo(a) was detected in 20 %; but in the presence of unstable plaques (UP) in coronary arteries [Lp(a)] is 1.8 times higher than in persons without UP. Average [Lp(a)]+ ([Лп(а)]>0) at Chukchi male made 28,1 mg/dl, Chukchi female have 28,4 mg/dl, at Eskimos with [Lp(a)]+ the median of the [Lp(a)] - 22,4 mg/dl, and the mode - 15,5 mg/dl. In the aboriginals of Chukotka with AH, apo(a) S1, S2 occurred a little more frequently than among those without AH. Along with lipoprotein apheresis and niacin, apolipoprotein-(B-100)-antisense mipomersen, inhibitor of PCSK9 and apolipoprotein-(a)-antisense (oligonucleotide), showed promising results in reducing [Lp(a)]. In Russia, ehvolocumab and alirocoumab have been approved. |
format |
Article in Journal/Newspaper |
author |
I. N. Grigorieva Yu. I. Ragino T. I. Romanova |
author_facet |
I. N. Grigorieva Yu. I. Ragino T. I. Romanova |
author_sort |
I. N. Grigorieva |
title |
ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS |
title_short |
ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS |
title_full |
ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS |
title_fullStr |
ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS |
title_full_unstemmed |
ANALYSIS OF VARIATIONS OF LP(A) LEVELS AS A BIOMARKER OF CARDIOVASCULAR DISEASES IN VARIOUS POPULATIONS |
title_sort |
analysis of variations of lp(a) levels as a biomarker of cardiovascular diseases in various populations |
publisher |
Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
publishDate |
2018 |
url |
https://doi.org/10.15372/ATER20180106 https://doaj.org/article/aa0883b3e11d47eda3729b3579a91fc4 |
genre |
Chukchi Chukotka eskimo* |
genre_facet |
Chukchi Chukotka eskimo* |
op_source |
Атеросклероз, Vol 14, Iss 1, Pp 43-49 (2018) |
op_relation |
https://ateroskleroz.elpub.ru/jour/article/view/66/66 https://doaj.org/toc/2078-256X https://doi.org/10.15372/ATER20180106 2078-256X https://doaj.org/article/aa0883b3e11d47eda3729b3579a91fc4 |
op_doi |
https://doi.org/10.15372/ATER20180106 |
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