Metabolic Differences between Dogs of Different Body Sizes
Introduction. The domesticated dog, Canis lupus familiaris, has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs....
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ftdoajarticles:oai:doaj.org/article:a9e2cd69e92f4044bd3426a4a00da928 2023-05-15T15:50:25+02:00 Metabolic Differences between Dogs of Different Body Sizes Rondo P. Middleton Sebastien Lacroix Marie-Pier Scott-Boyer Nikola Dordevic Adam D. Kennedy Amanda R. Slusky Jerome Carayol Christina Petzinger-Germain Alison Beloshapka Jim Kaput 2017-01-01T00:00:00Z https://doi.org/10.1155/2017/4535710 https://doaj.org/article/a9e2cd69e92f4044bd3426a4a00da928 EN eng Hindawi Limited http://dx.doi.org/10.1155/2017/4535710 https://doaj.org/toc/2090-0724 https://doaj.org/toc/2090-0732 2090-0724 2090-0732 doi:10.1155/2017/4535710 https://doaj.org/article/a9e2cd69e92f4044bd3426a4a00da928 Journal of Nutrition and Metabolism, Vol 2017 (2017) Nutritional diseases. Deficiency diseases RC620-627 article 2017 ftdoajarticles https://doi.org/10.1155/2017/4535710 2022-12-31T09:41:20Z Introduction. The domesticated dog, Canis lupus familiaris, has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs. Objectives. This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. Methods. Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. Eighty-three canines from seven different breeds, fed the same kibble diet for 5 weeks, were used in the study. Results. 449 metabolites, 16 clinical parameters, and 6 bacteria (at the genus level) were significantly different between small and larger dogs. Hierarchical clustering of the metabolites yielded 8 modules associated with small dog size. Conclusion. Small dogs had a lower antioxidant status and differences in circulating amino acids. Some of the amino acid differences could be attributed to differences in microflora. Additionally, analysis of small dog metabolites and clinical parameters reflected a network which strongly associates with kidney function. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Journal of Nutrition and Metabolism 2017 1 11 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Nutritional diseases. Deficiency diseases RC620-627 |
spellingShingle |
Nutritional diseases. Deficiency diseases RC620-627 Rondo P. Middleton Sebastien Lacroix Marie-Pier Scott-Boyer Nikola Dordevic Adam D. Kennedy Amanda R. Slusky Jerome Carayol Christina Petzinger-Germain Alison Beloshapka Jim Kaput Metabolic Differences between Dogs of Different Body Sizes |
topic_facet |
Nutritional diseases. Deficiency diseases RC620-627 |
description |
Introduction. The domesticated dog, Canis lupus familiaris, has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs. Objectives. This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. Methods. Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. Eighty-three canines from seven different breeds, fed the same kibble diet for 5 weeks, were used in the study. Results. 449 metabolites, 16 clinical parameters, and 6 bacteria (at the genus level) were significantly different between small and larger dogs. Hierarchical clustering of the metabolites yielded 8 modules associated with small dog size. Conclusion. Small dogs had a lower antioxidant status and differences in circulating amino acids. Some of the amino acid differences could be attributed to differences in microflora. Additionally, analysis of small dog metabolites and clinical parameters reflected a network which strongly associates with kidney function. |
format |
Article in Journal/Newspaper |
author |
Rondo P. Middleton Sebastien Lacroix Marie-Pier Scott-Boyer Nikola Dordevic Adam D. Kennedy Amanda R. Slusky Jerome Carayol Christina Petzinger-Germain Alison Beloshapka Jim Kaput |
author_facet |
Rondo P. Middleton Sebastien Lacroix Marie-Pier Scott-Boyer Nikola Dordevic Adam D. Kennedy Amanda R. Slusky Jerome Carayol Christina Petzinger-Germain Alison Beloshapka Jim Kaput |
author_sort |
Rondo P. Middleton |
title |
Metabolic Differences between Dogs of Different Body Sizes |
title_short |
Metabolic Differences between Dogs of Different Body Sizes |
title_full |
Metabolic Differences between Dogs of Different Body Sizes |
title_fullStr |
Metabolic Differences between Dogs of Different Body Sizes |
title_full_unstemmed |
Metabolic Differences between Dogs of Different Body Sizes |
title_sort |
metabolic differences between dogs of different body sizes |
publisher |
Hindawi Limited |
publishDate |
2017 |
url |
https://doi.org/10.1155/2017/4535710 https://doaj.org/article/a9e2cd69e92f4044bd3426a4a00da928 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Journal of Nutrition and Metabolism, Vol 2017 (2017) |
op_relation |
http://dx.doi.org/10.1155/2017/4535710 https://doaj.org/toc/2090-0724 https://doaj.org/toc/2090-0732 2090-0724 2090-0732 doi:10.1155/2017/4535710 https://doaj.org/article/a9e2cd69e92f4044bd3426a4a00da928 |
op_doi |
https://doi.org/10.1155/2017/4535710 |
container_title |
Journal of Nutrition and Metabolism |
container_volume |
2017 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1766385362221924352 |