Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso
Abstract Background Malaria vectors have acquired widespread resistance throughout sub-Saharan Africa to many of the currently used insecticides. Hence, there is an urgent need to develop alternative strategies including the development of new insecticides for effective management of insecticide res...
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ftdoajarticles:oai:doaj.org/article:a9817f281b71418abb9dc99ba3189584 2023-05-15T15:17:05+02:00 Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso Koama Bayili Severin N’do Moussa Namountougou Roger Sanou Abdoulaye Ouattara Roch K. Dabiré Anicet G. Ouédraogo David Malone Abdoulaye Diabaté 2017-05-01T00:00:00Z https://doi.org/10.1186/s12936-017-1846-4 https://doaj.org/article/a9817f281b71418abb9dc99ba3189584 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-1846-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1846-4 1475-2875 https://doaj.org/article/a9817f281b71418abb9dc99ba3189584 Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017) Malaria Anopheles gambiae Chlorfenapyr Insecticide Bed net Pyrethroid resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-1846-4 2022-12-31T15:52:40Z Abstract Background Malaria vectors have acquired widespread resistance throughout sub-Saharan Africa to many of the currently used insecticides. Hence, there is an urgent need to develop alternative strategies including the development of new insecticides for effective management of insecticide resistance. To maintain progress against malaria, it is necessary to identify other residual insecticides for mosquito nets. In the present WHOPES phase II analogue study, the utility of chlorfenapyr, a pyrrole class insecticide mixed with alpha-cypermethrin on a long-lasting mosquito bed net was evaluated against Anopheles gambiae s.l. Methods Bed nets treated with chlorfenapyr and alpha-cypermethrin and mixture of both compounds were tested for their efficacy on mosquitoes. Washed (20 times) and unwashed of each type of treated nets and were tested according to WHOPES guidelines. Efficacy of nets were expressed in terms of blood-feeding inhibition rate, deterrence, induced exophily and mortality rate. The evaluation was conducted in experimental huts of Vallée du Kou seven (VK7) in Burkina Faso (West Africa) following WHOPES phase II guidelines. In addition, a WHOPES phase I evaluation was also performed. Results Mixture treated nets killed significantly (P < 0.05) more mosquitoes than solo alpha-cypermethrin nets, unwashed and washed. Proportionally, this equated to mortalities of 78 and 76% (for mixture nets) compared to only 17 and 10% (for solo alpha-cypermethrin) to An. gambiae, respectively. In contrast mixture net proportions were not significantly (P > 0.05) different from nets treated with chlorfenapyr 200 mg/m2 unwashed (86%). The washed and unwashed nets treated with the mixtures resulted in personal protection against An. gambiae s.l. biting 34 and 44%. In contrast the personal protection observed for washed and unwashed alpha-cypermethrin treated nets generated (14 and 24%), and chlorfenapyr solo treated net was rather low (22%). Conclusion Among all nets trialled, the combination of chlorfenapyr and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Anopheles gambiae Chlorfenapyr Insecticide Bed net Pyrethroid resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Anopheles gambiae Chlorfenapyr Insecticide Bed net Pyrethroid resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Koama Bayili Severin N’do Moussa Namountougou Roger Sanou Abdoulaye Ouattara Roch K. Dabiré Anicet G. Ouédraogo David Malone Abdoulaye Diabaté Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso |
topic_facet |
Malaria Anopheles gambiae Chlorfenapyr Insecticide Bed net Pyrethroid resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria vectors have acquired widespread resistance throughout sub-Saharan Africa to many of the currently used insecticides. Hence, there is an urgent need to develop alternative strategies including the development of new insecticides for effective management of insecticide resistance. To maintain progress against malaria, it is necessary to identify other residual insecticides for mosquito nets. In the present WHOPES phase II analogue study, the utility of chlorfenapyr, a pyrrole class insecticide mixed with alpha-cypermethrin on a long-lasting mosquito bed net was evaluated against Anopheles gambiae s.l. Methods Bed nets treated with chlorfenapyr and alpha-cypermethrin and mixture of both compounds were tested for their efficacy on mosquitoes. Washed (20 times) and unwashed of each type of treated nets and were tested according to WHOPES guidelines. Efficacy of nets were expressed in terms of blood-feeding inhibition rate, deterrence, induced exophily and mortality rate. The evaluation was conducted in experimental huts of Vallée du Kou seven (VK7) in Burkina Faso (West Africa) following WHOPES phase II guidelines. In addition, a WHOPES phase I evaluation was also performed. Results Mixture treated nets killed significantly (P < 0.05) more mosquitoes than solo alpha-cypermethrin nets, unwashed and washed. Proportionally, this equated to mortalities of 78 and 76% (for mixture nets) compared to only 17 and 10% (for solo alpha-cypermethrin) to An. gambiae, respectively. In contrast mixture net proportions were not significantly (P > 0.05) different from nets treated with chlorfenapyr 200 mg/m2 unwashed (86%). The washed and unwashed nets treated with the mixtures resulted in personal protection against An. gambiae s.l. biting 34 and 44%. In contrast the personal protection observed for washed and unwashed alpha-cypermethrin treated nets generated (14 and 24%), and chlorfenapyr solo treated net was rather low (22%). Conclusion Among all nets trialled, the combination of chlorfenapyr and ... |
format |
Article in Journal/Newspaper |
author |
Koama Bayili Severin N’do Moussa Namountougou Roger Sanou Abdoulaye Ouattara Roch K. Dabiré Anicet G. Ouédraogo David Malone Abdoulaye Diabaté |
author_facet |
Koama Bayili Severin N’do Moussa Namountougou Roger Sanou Abdoulaye Ouattara Roch K. Dabiré Anicet G. Ouédraogo David Malone Abdoulaye Diabaté |
author_sort |
Koama Bayili |
title |
Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso |
title_short |
Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso |
title_full |
Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso |
title_fullStr |
Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso |
title_full_unstemmed |
Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso |
title_sort |
evaluation of efficacy of interceptor® g2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant anopheles gambiae s.l. in burkina faso |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-1846-4 https://doaj.org/article/a9817f281b71418abb9dc99ba3189584 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-1846-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1846-4 1475-2875 https://doaj.org/article/a9817f281b71418abb9dc99ba3189584 |
op_doi |
https://doi.org/10.1186/s12936-017-1846-4 |
container_title |
Malaria Journal |
container_volume |
16 |
container_issue |
1 |
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1766347358967169024 |