Melioidosis: Clinical impact and public health threat in the tropics.
This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, and Northern A...
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ftdoajarticles:oai:doaj.org/article:a8e69e7f77684ecda070c11e0526b8a0 2023-05-15T15:08:22+02:00 Melioidosis: Clinical impact and public health threat in the tropics. Ramar Perumal Samy Bradley G Stiles Gautam Sethi Lina H K Lim 2017-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004738 https://doaj.org/article/a8e69e7f77684ecda070c11e0526b8a0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5426594?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004738 https://doaj.org/article/a8e69e7f77684ecda070c11e0526b8a0 PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0004738 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004738 2022-12-30T21:27:57Z This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, and Northern Australia. Melioidosis patients are increasingly being recognized in other parts of the world. The bacteria are intrinsically resistant to many antimicrobial agents, but prolonged treatment, especially with combinations of antibiotics, may be effective. Despite therapy, the overall case fatality rate of septicemia in melioidosis remains significantly high. Intracellular survival of the bacteria within macrophages may progress to chronic infections, and about 10% of patients suffer relapses. In the coming decades, melioidosis will increasingly afflict travelers throughout many global regions. Clinicians managing travelers returning from the subtropics or tropics with severe pneumonia or septicemia should consider acute melioidosis as a differential diagnosis. Patients with open skin wounds, diabetes, or chronic renal disease are at higher risk for melioidosis and should avoid direct contact with soil and standing water in endemic regions. Furthermore, there are fears that B. pseudomallei may be used as a biological weapon. Technological advancements in molecular diagnostics and antibiotic therapy are improving the disease outcomes in endemic areas throughout Asia. Research and development efforts on vaccine candidates against melioidosis are ongoing. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 5 e0004738 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ramar Perumal Samy Bradley G Stiles Gautam Sethi Lina H K Lim Melioidosis: Clinical impact and public health threat in the tropics. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, and Northern Australia. Melioidosis patients are increasingly being recognized in other parts of the world. The bacteria are intrinsically resistant to many antimicrobial agents, but prolonged treatment, especially with combinations of antibiotics, may be effective. Despite therapy, the overall case fatality rate of septicemia in melioidosis remains significantly high. Intracellular survival of the bacteria within macrophages may progress to chronic infections, and about 10% of patients suffer relapses. In the coming decades, melioidosis will increasingly afflict travelers throughout many global regions. Clinicians managing travelers returning from the subtropics or tropics with severe pneumonia or septicemia should consider acute melioidosis as a differential diagnosis. Patients with open skin wounds, diabetes, or chronic renal disease are at higher risk for melioidosis and should avoid direct contact with soil and standing water in endemic regions. Furthermore, there are fears that B. pseudomallei may be used as a biological weapon. Technological advancements in molecular diagnostics and antibiotic therapy are improving the disease outcomes in endemic areas throughout Asia. Research and development efforts on vaccine candidates against melioidosis are ongoing. |
format |
Article in Journal/Newspaper |
author |
Ramar Perumal Samy Bradley G Stiles Gautam Sethi Lina H K Lim |
author_facet |
Ramar Perumal Samy Bradley G Stiles Gautam Sethi Lina H K Lim |
author_sort |
Ramar Perumal Samy |
title |
Melioidosis: Clinical impact and public health threat in the tropics. |
title_short |
Melioidosis: Clinical impact and public health threat in the tropics. |
title_full |
Melioidosis: Clinical impact and public health threat in the tropics. |
title_fullStr |
Melioidosis: Clinical impact and public health threat in the tropics. |
title_full_unstemmed |
Melioidosis: Clinical impact and public health threat in the tropics. |
title_sort |
melioidosis: clinical impact and public health threat in the tropics. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0004738 https://doaj.org/article/a8e69e7f77684ecda070c11e0526b8a0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0004738 (2017) |
op_relation |
http://europepmc.org/articles/PMC5426594?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004738 https://doaj.org/article/a8e69e7f77684ecda070c11e0526b8a0 |
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https://doi.org/10.1371/journal.pntd.0004738 |
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PLOS Neglected Tropical Diseases |
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11 |
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5 |
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e0004738 |
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