Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology
Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore e...
Published in: | Marine Drugs |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2013
|
Subjects: | |
Online Access: | https://doi.org/10.3390/md11062013 https://doaj.org/article/a8ac291b26194518abd5a7b3513cfb18 |
id |
ftdoajarticles:oai:doaj.org/article:a8ac291b26194518abd5a7b3513cfb18 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:a8ac291b26194518abd5a7b3513cfb18 2023-05-15T13:53:05+02:00 Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology Hyun-Cheol Kim Hak Jun Kim Hye Yeon Koh Hye-Eun Shim Hackwon Do Sung Gu Lee Ravichandran N. Murugan Jun Hyuck Lee Jeong Kyu Bang 2013-06-01T00:00:00Z https://doi.org/10.3390/md11062013 https://doaj.org/article/a8ac291b26194518abd5a7b3513cfb18 EN eng MDPI AG http://www.mdpi.com/1660-3397/11/6/2013 https://doaj.org/toc/1660-3397 doi:10.3390/md11062013 1660-3397 https://doaj.org/article/a8ac291b26194518abd5a7b3513cfb18 Marine Drugs, Vol 11, Iss 6, Pp 2013-2041 (2013) antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis Biology (General) QH301-705.5 article 2013 ftdoajarticles https://doi.org/10.3390/md11062013 2022-12-30T22:29:07Z Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore essential to the survival of many marine teleost fishes that routinely encounter sub-zero temperatures. Owing to this property, AF(G)Ps have potential applications in many areas such as storage of cells or tissues at low temperature, ice slurries for refrigeration systems, and food storage. In contrast to AFGPs, which are composed of repeated tripeptide units (Ala-Ala-Thr)n with minor sequence variations, AFPs possess very different primary, secondary, and tertiary structures. The isolation and purification of AFGPs is laborious, costly, and often results in mixtures, making characterization difficult. Recent structural investigations into the mechanism by which linear and cyclic AFGPs inhibit ice crystallization have led to significant progress toward the synthesis and assessment of several synthetic mimics of AFGPs. This review article will summarize synthetic AFGP mimics as well as current challenges in designing compounds capable of mimicking AFGPs. It will also cover our recent efforts in exploring whether peptoid mimics can serve as structural and functional mimics of native AFGPs. Article in Journal/Newspaper Antarc* Antarctic Arctic Directory of Open Access Journals: DOAJ Articles Antarctic Arctic Marine Drugs 11 6 2013 2041 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis Biology (General) QH301-705.5 |
spellingShingle |
antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis Biology (General) QH301-705.5 Hyun-Cheol Kim Hak Jun Kim Hye Yeon Koh Hye-Eun Shim Hackwon Do Sung Gu Lee Ravichandran N. Murugan Jun Hyuck Lee Jeong Kyu Bang Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
topic_facet |
antifreeze glycopeptide antifreeze protein recrystallization inhibition thermal hysteresis Biology (General) QH301-705.5 |
description |
Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore essential to the survival of many marine teleost fishes that routinely encounter sub-zero temperatures. Owing to this property, AF(G)Ps have potential applications in many areas such as storage of cells or tissues at low temperature, ice slurries for refrigeration systems, and food storage. In contrast to AFGPs, which are composed of repeated tripeptide units (Ala-Ala-Thr)n with minor sequence variations, AFPs possess very different primary, secondary, and tertiary structures. The isolation and purification of AFGPs is laborious, costly, and often results in mixtures, making characterization difficult. Recent structural investigations into the mechanism by which linear and cyclic AFGPs inhibit ice crystallization have led to significant progress toward the synthesis and assessment of several synthetic mimics of AFGPs. This review article will summarize synthetic AFGP mimics as well as current challenges in designing compounds capable of mimicking AFGPs. It will also cover our recent efforts in exploring whether peptoid mimics can serve as structural and functional mimics of native AFGPs. |
format |
Article in Journal/Newspaper |
author |
Hyun-Cheol Kim Hak Jun Kim Hye Yeon Koh Hye-Eun Shim Hackwon Do Sung Gu Lee Ravichandran N. Murugan Jun Hyuck Lee Jeong Kyu Bang |
author_facet |
Hyun-Cheol Kim Hak Jun Kim Hye Yeon Koh Hye-Eun Shim Hackwon Do Sung Gu Lee Ravichandran N. Murugan Jun Hyuck Lee Jeong Kyu Bang |
author_sort |
Hyun-Cheol Kim |
title |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_short |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_full |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_fullStr |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_full_unstemmed |
Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology |
title_sort |
antifreeze peptides and glycopeptides, and their derivatives: potential uses in biotechnology |
publisher |
MDPI AG |
publishDate |
2013 |
url |
https://doi.org/10.3390/md11062013 https://doaj.org/article/a8ac291b26194518abd5a7b3513cfb18 |
geographic |
Antarctic Arctic |
geographic_facet |
Antarctic Arctic |
genre |
Antarc* Antarctic Arctic |
genre_facet |
Antarc* Antarctic Arctic |
op_source |
Marine Drugs, Vol 11, Iss 6, Pp 2013-2041 (2013) |
op_relation |
http://www.mdpi.com/1660-3397/11/6/2013 https://doaj.org/toc/1660-3397 doi:10.3390/md11062013 1660-3397 https://doaj.org/article/a8ac291b26194518abd5a7b3513cfb18 |
op_doi |
https://doi.org/10.3390/md11062013 |
container_title |
Marine Drugs |
container_volume |
11 |
container_issue |
6 |
container_start_page |
2013 |
op_container_end_page |
2041 |
_version_ |
1766258035581255680 |