Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa.
Background The multi-host taeniosis/cysticercosis disease system is associated with significant neurological morbidity, as well as economic burden, globally. We investigated whether lower cost behavioral interventions are sufficient for local elimination of human cysticercosis in Boulkiemdé, Sanguié...
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ftdoajarticles:oai:doaj.org/article:a8957c1a93244d91a4dddc9061243978 2023-05-15T15:12:38+02:00 Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. Laura A Skrip Veronique Dermauw Pierre Dorny Rasmané Ganaba Athanase Millogo Zékiba Tarnagda Hélène Carabin 2021-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009234 https://doaj.org/article/a8957c1a93244d91a4dddc9061243978 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009234 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009234 https://doaj.org/article/a8957c1a93244d91a4dddc9061243978 PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009234 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009234 2022-12-31T05:57:01Z Background The multi-host taeniosis/cysticercosis disease system is associated with significant neurological morbidity, as well as economic burden, globally. We investigated whether lower cost behavioral interventions are sufficient for local elimination of human cysticercosis in Boulkiemdé, Sanguié, and Nayala provinces of Burkina Faso. Methodology/principal findings Province-specific data on human behaviors (i.e., latrine use and pork consumption) and serological prevalence of human and pig disease were used to inform a deterministic, compartmental model of the taeniosis/cysticercosis disease system. Parameters estimated via Bayesian melding provided posterior distributions for comparing transmission rates associated with human ingestion of Taenia solium cysticerci due to undercooking and human exposure to T. solium eggs in the environment. Reductions in transmission via these pathways were modeled to determine required effectiveness of a market-focused cooking behavior intervention and a community-led sanitation and hygiene program, independently and in combination, for eliminating human cysticercosis as a public health problem (<1 case per 1000 population). Transmission of cysticerci due to consumption of undercooked pork was found to vary significantly across transmission settings. In Sanguié, the rate of transmission due to undercooking was 6% higher than that in Boulkiemdé (95% CI: 1.03, 1.09; p-value < 0.001) and 35% lower than that in Nayala (95% CI: 0.64, 0.66; p-value < 0.001). We found that 67% and 62% reductions in undercooking of pork consumed in markets were associated with elimination of cysticercosis in Nayala and Sanguié, respectively. Elimination of active cysticercosis in Boulkiemdé required a 73% reduction. Less aggressive reductions of 25% to 30% in human exposure to Taenia solium eggs through sanitation and hygiene programs were associated with elimination in the provinces. Conclusions/significance Despite heterogeneity in effectiveness due to local transmission dynamics and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 3 e0009234 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Laura A Skrip Veronique Dermauw Pierre Dorny Rasmané Ganaba Athanase Millogo Zékiba Tarnagda Hélène Carabin Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The multi-host taeniosis/cysticercosis disease system is associated with significant neurological morbidity, as well as economic burden, globally. We investigated whether lower cost behavioral interventions are sufficient for local elimination of human cysticercosis in Boulkiemdé, Sanguié, and Nayala provinces of Burkina Faso. Methodology/principal findings Province-specific data on human behaviors (i.e., latrine use and pork consumption) and serological prevalence of human and pig disease were used to inform a deterministic, compartmental model of the taeniosis/cysticercosis disease system. Parameters estimated via Bayesian melding provided posterior distributions for comparing transmission rates associated with human ingestion of Taenia solium cysticerci due to undercooking and human exposure to T. solium eggs in the environment. Reductions in transmission via these pathways were modeled to determine required effectiveness of a market-focused cooking behavior intervention and a community-led sanitation and hygiene program, independently and in combination, for eliminating human cysticercosis as a public health problem (<1 case per 1000 population). Transmission of cysticerci due to consumption of undercooked pork was found to vary significantly across transmission settings. In Sanguié, the rate of transmission due to undercooking was 6% higher than that in Boulkiemdé (95% CI: 1.03, 1.09; p-value < 0.001) and 35% lower than that in Nayala (95% CI: 0.64, 0.66; p-value < 0.001). We found that 67% and 62% reductions in undercooking of pork consumed in markets were associated with elimination of cysticercosis in Nayala and Sanguié, respectively. Elimination of active cysticercosis in Boulkiemdé required a 73% reduction. Less aggressive reductions of 25% to 30% in human exposure to Taenia solium eggs through sanitation and hygiene programs were associated with elimination in the provinces. Conclusions/significance Despite heterogeneity in effectiveness due to local transmission dynamics and ... |
format |
Article in Journal/Newspaper |
author |
Laura A Skrip Veronique Dermauw Pierre Dorny Rasmané Ganaba Athanase Millogo Zékiba Tarnagda Hélène Carabin |
author_facet |
Laura A Skrip Veronique Dermauw Pierre Dorny Rasmané Ganaba Athanase Millogo Zékiba Tarnagda Hélène Carabin |
author_sort |
Laura A Skrip |
title |
Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. |
title_short |
Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. |
title_full |
Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. |
title_fullStr |
Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. |
title_full_unstemmed |
Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa. |
title_sort |
data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-saharan africa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009234 https://doaj.org/article/a8957c1a93244d91a4dddc9061243978 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009234 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009234 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009234 https://doaj.org/article/a8957c1a93244d91a4dddc9061243978 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009234 |
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PLOS Neglected Tropical Diseases |
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15 |
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3 |
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e0009234 |
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