Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study
The City of Yellowknife is a known hotspot of arsenic contamination and there is a growing body of evidence suggesting that local wildlife in the vicinity of the abandoned Giant Mine site may be at risk of decreased bone mineralization and various bone disorders. The purpose of this study was to pre...
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Online Access: | https://doi.org/10.1016/j.ecoenv.2020.111721 https://doaj.org/article/a833c5c3978b46a6857dad8c2130f601 |
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ftdoajarticles:oai:doaj.org/article:a833c5c3978b46a6857dad8c2130f601 2023-05-15T17:46:39+02:00 Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study S. Amuno K. Shekh V. Kodzhahinchev S. Niyogi A. Al Kaissi 2021-01-01T00:00:00Z https://doi.org/10.1016/j.ecoenv.2020.111721 https://doaj.org/article/a833c5c3978b46a6857dad8c2130f601 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S014765132031558X https://doaj.org/toc/0147-6513 0147-6513 doi:10.1016/j.ecoenv.2020.111721 https://doaj.org/article/a833c5c3978b46a6857dad8c2130f601 Ecotoxicology and Environmental Safety, Vol 208, Iss , Pp 111721- (2021) Arsenic poisoning Bone disorders Bone mineral density Small mammals Environmental pollution TD172-193.5 Environmental sciences GE1-350 article 2021 ftdoajarticles https://doi.org/10.1016/j.ecoenv.2020.111721 2022-12-31T07:55:11Z The City of Yellowknife is a known hotspot of arsenic contamination and there is a growing body of evidence suggesting that local wildlife in the vicinity of the abandoned Giant Mine site may be at risk of decreased bone mineralization and various bone disorders. The purpose of this study was to preliminarily measure bone mineral density (BMD) changes and investigate the incidence, pattern, and severity of bone lesions in wild muskrats and red squirrels breeding in three (3) catchment areas at different distances from the Giant Mine Site in Yellowknife, Northwest Territories (Canada): ~2 km (location 1), ~18 km (location 2), and ~40–100 km (location 3). Full femoral bones of 15 muskrats and 15 red squirrels were collected from the three sampling locations (5 from each location) and subjected to radiographic analysis and densitometric measurements. The patterns and severities of bone lesions, including changes in bone mineral density, were evaluated and compared between groups. As levels were significantly higher in the bones of muskrats caught from location 1 and 2, relative to location 3. Further, As and Cd levels were significantly higher in the bones of squirrels caught from locations 1 and 2 relative to squirrels caught from location 3. The preliminary results from bones revealed that radiographic abnormalities such as bone rarefaction, osteopenia, and thinning of the femoral shafts with significant ossific cystic lesions and bowing were the most common skeletal pathologies found in bones of red squirrels from the three locations. Radiographic appearances of massive sclerosis and dysplasia, including severe osteocondensation and osteopathia striata-like abnormalities, were found in the bones of muskrats from all the sampling locations. Densitometric evaluation showed no significant differences between the three locations in the bone parameters measured. However, there was a statistically significant correlation between As content in the bones of muskrats and percent fat content in the femur samples, which ... Article in Journal/Newspaper Northwest Territories Yellowknife Directory of Open Access Journals: DOAJ Articles Canada Northwest Territories Yellowknife Ecotoxicology and Environmental Safety 208 111721 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arsenic poisoning Bone disorders Bone mineral density Small mammals Environmental pollution TD172-193.5 Environmental sciences GE1-350 |
spellingShingle |
Arsenic poisoning Bone disorders Bone mineral density Small mammals Environmental pollution TD172-193.5 Environmental sciences GE1-350 S. Amuno K. Shekh V. Kodzhahinchev S. Niyogi A. Al Kaissi Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study |
topic_facet |
Arsenic poisoning Bone disorders Bone mineral density Small mammals Environmental pollution TD172-193.5 Environmental sciences GE1-350 |
description |
The City of Yellowknife is a known hotspot of arsenic contamination and there is a growing body of evidence suggesting that local wildlife in the vicinity of the abandoned Giant Mine site may be at risk of decreased bone mineralization and various bone disorders. The purpose of this study was to preliminarily measure bone mineral density (BMD) changes and investigate the incidence, pattern, and severity of bone lesions in wild muskrats and red squirrels breeding in three (3) catchment areas at different distances from the Giant Mine Site in Yellowknife, Northwest Territories (Canada): ~2 km (location 1), ~18 km (location 2), and ~40–100 km (location 3). Full femoral bones of 15 muskrats and 15 red squirrels were collected from the three sampling locations (5 from each location) and subjected to radiographic analysis and densitometric measurements. The patterns and severities of bone lesions, including changes in bone mineral density, were evaluated and compared between groups. As levels were significantly higher in the bones of muskrats caught from location 1 and 2, relative to location 3. Further, As and Cd levels were significantly higher in the bones of squirrels caught from locations 1 and 2 relative to squirrels caught from location 3. The preliminary results from bones revealed that radiographic abnormalities such as bone rarefaction, osteopenia, and thinning of the femoral shafts with significant ossific cystic lesions and bowing were the most common skeletal pathologies found in bones of red squirrels from the three locations. Radiographic appearances of massive sclerosis and dysplasia, including severe osteocondensation and osteopathia striata-like abnormalities, were found in the bones of muskrats from all the sampling locations. Densitometric evaluation showed no significant differences between the three locations in the bone parameters measured. However, there was a statistically significant correlation between As content in the bones of muskrats and percent fat content in the femur samples, which ... |
format |
Article in Journal/Newspaper |
author |
S. Amuno K. Shekh V. Kodzhahinchev S. Niyogi A. Al Kaissi |
author_facet |
S. Amuno K. Shekh V. Kodzhahinchev S. Niyogi A. Al Kaissi |
author_sort |
S. Amuno |
title |
Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study |
title_short |
Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study |
title_full |
Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study |
title_fullStr |
Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study |
title_full_unstemmed |
Skeletal pathology and bone mineral density changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) inhabiting arsenic polluted areas of Yellowknife, Northwest Territories (Canada): A radiographic densitometry study |
title_sort |
skeletal pathology and bone mineral density changes in wild muskrats (ondatra zibethicus) and red squirrels (tamiasciurus hudsonicus) inhabiting arsenic polluted areas of yellowknife, northwest territories (canada): a radiographic densitometry study |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://doi.org/10.1016/j.ecoenv.2020.111721 https://doaj.org/article/a833c5c3978b46a6857dad8c2130f601 |
geographic |
Canada Northwest Territories Yellowknife |
geographic_facet |
Canada Northwest Territories Yellowknife |
genre |
Northwest Territories Yellowknife |
genre_facet |
Northwest Territories Yellowknife |
op_source |
Ecotoxicology and Environmental Safety, Vol 208, Iss , Pp 111721- (2021) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S014765132031558X https://doaj.org/toc/0147-6513 0147-6513 doi:10.1016/j.ecoenv.2020.111721 https://doaj.org/article/a833c5c3978b46a6857dad8c2130f601 |
op_doi |
https://doi.org/10.1016/j.ecoenv.2020.111721 |
container_title |
Ecotoxicology and Environmental Safety |
container_volume |
208 |
container_start_page |
111721 |
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1766150426080575488 |