Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us.
Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived...
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ftdoajarticles:oai:doaj.org/article:a82a19ef2cac4678b2ba1e8a6544b14d 2023-05-15T15:13:12+02:00 Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. Fouad El Baidouri Laure Diancourt Vincent Berry François Chevenet Francine Pratlong Pierre Marty Christophe Ravel 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002255 https://doaj.org/article/a82a19ef2cac4678b2ba1e8a6544b14d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3681676?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002255 https://doaj.org/article/a82a19ef2cac4678b2ba1e8a6544b14d PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2255 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002255 2022-12-31T07:25:13Z Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After arguing that genetic exchanges were exceptional and did not contribute to Leishmania evolution, it is currently proposed that interspecific exchanges could be a major driving force for rapid adaptation to new reservoirs and vectors, expansion into new parasitic cycles and adaptation to new life conditions. To assess the existence of gene flows between species during evolution we used MLSA-based (MultiLocus Sequence Analysis) approach to analyze 222 Leishmania strains from Africa and Eurasia to accurately represent the genetic diversity of this genus. We observed a remarkable congruence of the phylogenetic signal and identified seven genetic clusters that include mainly independent lineages which are accumulating divergences without any sign of recent interspecific recombination. From a taxonomic point of view, the strong genetic structuration of the different species does not question the current classification, except for species that cause visceral forms of leishmaniasis (L. donovani, L. infantum and L. archibaldi). Although these taxa cause specific clinical forms of the disease and are maintained through different parasitic cycles, they are not clearly distinct and form a continuum, in line with the concept of species complex already suggested for this group thirty years ago. These results should have practical consequences concerning the molecular identification of parasites and the subsequent therapeutic management of the disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 6 e2255 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Fouad El Baidouri Laure Diancourt Vincent Berry François Chevenet Francine Pratlong Pierre Marty Christophe Ravel Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After arguing that genetic exchanges were exceptional and did not contribute to Leishmania evolution, it is currently proposed that interspecific exchanges could be a major driving force for rapid adaptation to new reservoirs and vectors, expansion into new parasitic cycles and adaptation to new life conditions. To assess the existence of gene flows between species during evolution we used MLSA-based (MultiLocus Sequence Analysis) approach to analyze 222 Leishmania strains from Africa and Eurasia to accurately represent the genetic diversity of this genus. We observed a remarkable congruence of the phylogenetic signal and identified seven genetic clusters that include mainly independent lineages which are accumulating divergences without any sign of recent interspecific recombination. From a taxonomic point of view, the strong genetic structuration of the different species does not question the current classification, except for species that cause visceral forms of leishmaniasis (L. donovani, L. infantum and L. archibaldi). Although these taxa cause specific clinical forms of the disease and are maintained through different parasitic cycles, they are not clearly distinct and form a continuum, in line with the concept of species complex already suggested for this group thirty years ago. These results should have practical consequences concerning the molecular identification of parasites and the subsequent therapeutic management of the disease. |
format |
Article in Journal/Newspaper |
author |
Fouad El Baidouri Laure Diancourt Vincent Berry François Chevenet Francine Pratlong Pierre Marty Christophe Ravel |
author_facet |
Fouad El Baidouri Laure Diancourt Vincent Berry François Chevenet Francine Pratlong Pierre Marty Christophe Ravel |
author_sort |
Fouad El Baidouri |
title |
Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. |
title_short |
Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. |
title_full |
Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. |
title_fullStr |
Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. |
title_full_unstemmed |
Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us. |
title_sort |
genetic structure and evolution of the leishmania genus in africa and eurasia: what does mlsa tell us. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002255 https://doaj.org/article/a82a19ef2cac4678b2ba1e8a6544b14d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2255 (2013) |
op_relation |
http://europepmc.org/articles/PMC3681676?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002255 https://doaj.org/article/a82a19ef2cac4678b2ba1e8a6544b14d |
op_doi |
https://doi.org/10.1371/journal.pntd.0002255 |
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PLoS Neglected Tropical Diseases |
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7 |
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6 |
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e2255 |
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