The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic
The epidemiological situation in Tajikistan Republic deteriorated in the 1990s, when an influx of refugees from Afghanistan resulted in mass importation of Plasmodium vivax and Plasmodium falciparum malaria to Khatlon region. The National Programme of Malaria Control was successful and malaria trans...
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ftdoajarticles:oai:doaj.org/article:a80ec55cfa8a45aaa004fc5b7f45d83c 2023-05-15T15:11:56+02:00 The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic Nighina M. Khodzhaeva Alla M. Baranova Anatoly K. Tokmalaev 2019-01-01T00:00:00Z https://doi.org/10.1155/2019/5147252 https://doaj.org/article/a80ec55cfa8a45aaa004fc5b7f45d83c EN eng Hindawi Limited http://dx.doi.org/10.1155/2019/5147252 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2019/5147252 https://doaj.org/article/a80ec55cfa8a45aaa004fc5b7f45d83c Journal of Tropical Medicine, Vol 2019 (2019) Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1155/2019/5147252 2022-12-31T09:31:58Z The epidemiological situation in Tajikistan Republic deteriorated in the 1990s, when an influx of refugees from Afghanistan resulted in mass importation of Plasmodium vivax and Plasmodium falciparum malaria to Khatlon region. The National Programme of Malaria Control was successful and malaria transmission was interrupted in 2009. Background. The aim of this study was to investigate the mechanisms of immunological response in Tajik children with tropical Plasmodium falciparum malaria. Materials and Methods. We examined 124 patients with P. falciparum malaria at the age of 6 months up to 14 years that were hospitalized in Clinical Infectious Diseases Hospital in Dushanbe city and in Regional hospital of Khatlon region in the period 2000-2007. In most cases, they were school-age children (56%). The peak incidence was recorded in July-October. Verification of the diagnosis was based on clinical, epidemiological data, and the results of blood microscopy. In all patients, along with the standard, clinical, and laboratory tests, a number of indicators of the immune status were performed that include the T-immunity, the content of serum immunoglobulins of three main classes, the level of circulating immune complexes (CIC), C3 complement, and the concentration of key serum cytokines that have been studied in the dynamics of infectious process. Finding. The study of cellular and humoral immunity in patients with Plasmodium falciparum malaria is an obvious additional criterion in assessing the severity of infection. The imbalance of cytokine profile is an important pathogenic factor in the development of severe and recurrent forms of the disease, since the formation of a defective immune response to parasitic antigens contributes to adverse outcomes. Conclusions. Plasmodium falciparum malaria was characterized by depression of cellular and humoral immunity, the degree of which depended on the severity of the pathological process. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2019 1 6 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Nighina M. Khodzhaeva Alla M. Baranova Anatoly K. Tokmalaev The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The epidemiological situation in Tajikistan Republic deteriorated in the 1990s, when an influx of refugees from Afghanistan resulted in mass importation of Plasmodium vivax and Plasmodium falciparum malaria to Khatlon region. The National Programme of Malaria Control was successful and malaria transmission was interrupted in 2009. Background. The aim of this study was to investigate the mechanisms of immunological response in Tajik children with tropical Plasmodium falciparum malaria. Materials and Methods. We examined 124 patients with P. falciparum malaria at the age of 6 months up to 14 years that were hospitalized in Clinical Infectious Diseases Hospital in Dushanbe city and in Regional hospital of Khatlon region in the period 2000-2007. In most cases, they were school-age children (56%). The peak incidence was recorded in July-October. Verification of the diagnosis was based on clinical, epidemiological data, and the results of blood microscopy. In all patients, along with the standard, clinical, and laboratory tests, a number of indicators of the immune status were performed that include the T-immunity, the content of serum immunoglobulins of three main classes, the level of circulating immune complexes (CIC), C3 complement, and the concentration of key serum cytokines that have been studied in the dynamics of infectious process. Finding. The study of cellular and humoral immunity in patients with Plasmodium falciparum malaria is an obvious additional criterion in assessing the severity of infection. The imbalance of cytokine profile is an important pathogenic factor in the development of severe and recurrent forms of the disease, since the formation of a defective immune response to parasitic antigens contributes to adverse outcomes. Conclusions. Plasmodium falciparum malaria was characterized by depression of cellular and humoral immunity, the degree of which depended on the severity of the pathological process. |
format |
Article in Journal/Newspaper |
author |
Nighina M. Khodzhaeva Alla M. Baranova Anatoly K. Tokmalaev |
author_facet |
Nighina M. Khodzhaeva Alla M. Baranova Anatoly K. Tokmalaev |
author_sort |
Nighina M. Khodzhaeva |
title |
The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic |
title_short |
The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic |
title_full |
The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic |
title_fullStr |
The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic |
title_full_unstemmed |
The Immunological Plasmodium falciparum Malaria Characteristics of Children in Tajikistan Republic |
title_sort |
immunological plasmodium falciparum malaria characteristics of children in tajikistan republic |
publisher |
Hindawi Limited |
publishDate |
2019 |
url |
https://doi.org/10.1155/2019/5147252 https://doaj.org/article/a80ec55cfa8a45aaa004fc5b7f45d83c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2019 (2019) |
op_relation |
http://dx.doi.org/10.1155/2019/5147252 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2019/5147252 https://doaj.org/article/a80ec55cfa8a45aaa004fc5b7f45d83c |
op_doi |
https://doi.org/10.1155/2019/5147252 |
container_title |
Journal of Tropical Medicine |
container_volume |
2019 |
container_start_page |
1 |
op_container_end_page |
6 |
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1766342700037046272 |