The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity.
Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0011651 https://doaj.org/article/a7946097885a407bb8af5bd7374caa09 |
id |
ftdoajarticles:oai:doaj.org/article:a7946097885a407bb8af5bd7374caa09 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:a7946097885a407bb8af5bd7374caa09 2023-11-12T04:13:14+01:00 The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. Louella M R Kasbergen David F Nieuwenhuijse Erwin de Bruin Reina S Sikkema Marion P G Koopmans 2023-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011651 https://doaj.org/article/a7946097885a407bb8af5bd7374caa09 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011651&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011651 https://doaj.org/article/a7946097885a407bb8af5bd7374caa09 PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011651 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011651 2023-10-22T00:42:50Z Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or studies that did not meet the inclusion criteria regarding confirmation of virus exposure of reference population sets. Using a scoring system to further assess quality of studies, we show that the majority of the selected papers (N = 102) provides insufficient detail to support conclusions on specificity of serological outcomes with regards to elucidating antibody cross-reactivity. Along with the lack of standardization of assays, metadata such as time of illness onset, vaccination, infection and travel history, age and specificity of serological methods were most frequently missing. Given the critical role of serology for diagnosis and surveillance of arbovirus infections, better standards for reporting, as well as the development of more (standardized) specific serological assays that allow discrimination between exposures to multiple different arboviruses, are a large global unmet need. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 9 e0011651 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Louella M R Kasbergen David F Nieuwenhuijse Erwin de Bruin Reina S Sikkema Marion P G Koopmans The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or studies that did not meet the inclusion criteria regarding confirmation of virus exposure of reference population sets. Using a scoring system to further assess quality of studies, we show that the majority of the selected papers (N = 102) provides insufficient detail to support conclusions on specificity of serological outcomes with regards to elucidating antibody cross-reactivity. Along with the lack of standardization of assays, metadata such as time of illness onset, vaccination, infection and travel history, age and specificity of serological methods were most frequently missing. Given the critical role of serology for diagnosis and surveillance of arbovirus infections, better standards for reporting, as well as the development of more (standardized) specific serological assays that allow discrimination between exposures to multiple different arboviruses, are a large global unmet need. |
format |
Article in Journal/Newspaper |
author |
Louella M R Kasbergen David F Nieuwenhuijse Erwin de Bruin Reina S Sikkema Marion P G Koopmans |
author_facet |
Louella M R Kasbergen David F Nieuwenhuijse Erwin de Bruin Reina S Sikkema Marion P G Koopmans |
author_sort |
Louella M R Kasbergen |
title |
The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. |
title_short |
The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. |
title_full |
The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. |
title_fullStr |
The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. |
title_full_unstemmed |
The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity. |
title_sort |
increasing complexity of arbovirus serology: an in-depth systematic review on cross-reactivity. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011651 https://doaj.org/article/a7946097885a407bb8af5bd7374caa09 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011651 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011651&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011651 https://doaj.org/article/a7946097885a407bb8af5bd7374caa09 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011651 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
9 |
container_start_page |
e0011651 |
_version_ |
1782331339881578496 |