Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study
Abstract Background Connective tissue disease-associated interstitial lung disease (CTD-ILD) is associated with reduced quality of life and poor prognosis. Prior studies have not identified a consistent combination of variables that accurately predict prognosis in CTD-ILD. The objective of this stud...
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ftdoajarticles:oai:doaj.org/article:a754ad4cd3934b07a2c7746a442b2fb5 2023-05-15T16:16:02+02:00 Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study Chrystal Chan Christopher J. Ryerson James V. Dunne Pearce G. Wilcox 2019-10-01T00:00:00Z https://doi.org/10.1186/s12890-019-0943-2 https://doaj.org/article/a754ad4cd3934b07a2c7746a442b2fb5 EN eng BMC http://link.springer.com/article/10.1186/s12890-019-0943-2 https://doaj.org/toc/1471-2466 doi:10.1186/s12890-019-0943-2 1471-2466 https://doaj.org/article/a754ad4cd3934b07a2c7746a442b2fb5 BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019) Interstitial lung disease Connective tissue disease Prognosis Survival Diseases of the respiratory system RC705-779 article 2019 ftdoajarticles https://doi.org/10.1186/s12890-019-0943-2 2022-12-31T14:02:44Z Abstract Background Connective tissue disease-associated interstitial lung disease (CTD-ILD) is associated with reduced quality of life and poor prognosis. Prior studies have not identified a consistent combination of variables that accurately predict prognosis in CTD-ILD. The objective of this study was to identify baseline demographic and clinical characteristics that are associated with progression and mortality in CTD-ILD. Methods Patients were retrospectively identified from an adult CTD-ILD clinic. The predictive significance of baseline variables on serial forced vital capacity (FVC), diffusion capacity (DLCO), and six-minute walk distance (6MWD) was assessed using linear mixed effects models, and Cox regression analysis was performed to assess impact on mortality. Results 359 patients were included in the study. Median follow-up time was 4.0 (IQR 1.5–7.6) years. On both unadjusted and multivariable analysis, male sex and South Asian ethnicity were associated with decline in FVC. Male sex, positive smoking history, and diagnosis of systemic sclerosis (SSc) vs. other CTD were associated with decline in DLCO. Male sex and usual interstitial pneumonia (UIP) pattern predicted decline in 6MWD. There were 85 (23.7%) deaths. Male sex, older age, First Nations ethnicity, and a diagnosis of systemic sclerosis vs. rheumatoid arthritis were predictors of mortality on unadjusted and multivariable analysis. Conclusion Male sex, older age, smoking, South Asian or First Nations ethnicity, and UIP pattern predicted decline in lung function and/or mortality in CTD-ILD. Further longitudinal studies may add to current clinical prediction models for prognostication in CTD-ILD. Article in Journal/Newspaper First Nations Directory of Open Access Journals: DOAJ Articles BMC Pulmonary Medicine 19 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Interstitial lung disease Connective tissue disease Prognosis Survival Diseases of the respiratory system RC705-779 |
spellingShingle |
Interstitial lung disease Connective tissue disease Prognosis Survival Diseases of the respiratory system RC705-779 Chrystal Chan Christopher J. Ryerson James V. Dunne Pearce G. Wilcox Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
topic_facet |
Interstitial lung disease Connective tissue disease Prognosis Survival Diseases of the respiratory system RC705-779 |
description |
Abstract Background Connective tissue disease-associated interstitial lung disease (CTD-ILD) is associated with reduced quality of life and poor prognosis. Prior studies have not identified a consistent combination of variables that accurately predict prognosis in CTD-ILD. The objective of this study was to identify baseline demographic and clinical characteristics that are associated with progression and mortality in CTD-ILD. Methods Patients were retrospectively identified from an adult CTD-ILD clinic. The predictive significance of baseline variables on serial forced vital capacity (FVC), diffusion capacity (DLCO), and six-minute walk distance (6MWD) was assessed using linear mixed effects models, and Cox regression analysis was performed to assess impact on mortality. Results 359 patients were included in the study. Median follow-up time was 4.0 (IQR 1.5–7.6) years. On both unadjusted and multivariable analysis, male sex and South Asian ethnicity were associated with decline in FVC. Male sex, positive smoking history, and diagnosis of systemic sclerosis (SSc) vs. other CTD were associated with decline in DLCO. Male sex and usual interstitial pneumonia (UIP) pattern predicted decline in 6MWD. There were 85 (23.7%) deaths. Male sex, older age, First Nations ethnicity, and a diagnosis of systemic sclerosis vs. rheumatoid arthritis were predictors of mortality on unadjusted and multivariable analysis. Conclusion Male sex, older age, smoking, South Asian or First Nations ethnicity, and UIP pattern predicted decline in lung function and/or mortality in CTD-ILD. Further longitudinal studies may add to current clinical prediction models for prognostication in CTD-ILD. |
format |
Article in Journal/Newspaper |
author |
Chrystal Chan Christopher J. Ryerson James V. Dunne Pearce G. Wilcox |
author_facet |
Chrystal Chan Christopher J. Ryerson James V. Dunne Pearce G. Wilcox |
author_sort |
Chrystal Chan |
title |
Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
title_short |
Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
title_full |
Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
title_fullStr |
Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
title_full_unstemmed |
Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
title_sort |
demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12890-019-0943-2 https://doaj.org/article/a754ad4cd3934b07a2c7746a442b2fb5 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12890-019-0943-2 https://doaj.org/toc/1471-2466 doi:10.1186/s12890-019-0943-2 1471-2466 https://doaj.org/article/a754ad4cd3934b07a2c7746a442b2fb5 |
op_doi |
https://doi.org/10.1186/s12890-019-0943-2 |
container_title |
BMC Pulmonary Medicine |
container_volume |
19 |
container_issue |
1 |
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1766001902146813952 |