Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença
Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 4...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Language: | English |
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Universidade de São Paulo (USP)
1993
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ftdoajarticles:oai:doaj.org/article:a74dcaeb78eb44d4be6d8e5e7183fef9 2024-09-09T19:27:48+00:00 Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença Fernando Schemelzer de Moraes Bezerra Paulo Marcos Zech Coelho Carlos Alberto Pereira Tavares 1993-08-01T00:00:00Z https://doi.org/10.1590/S0036-46651993000400006 https://doaj.org/article/a74dcaeb78eb44d4be6d8e5e7183fef9 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000400006 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651993000400006 0036-4665 1678-9946 https://doaj.org/article/a74dcaeb78eb44d4be6d8e5e7183fef9 Revista do Instituto de Medicina Tropical de São Paulo, Vol 35, Iss 4, Pp 337-344 (1993) Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1993 ftdoajarticles https://doi.org/10.1590/S0036-46651993000400006 2024-08-05T17:49:30Z Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possible to detect a decrease of antibody levels (total IgG) in the treated group, when antigens from different evolutive stages of S. mansoni were used. The epidemiological implications of the present results, and the possible mechanisms involved in the decrease of acquired immunity after treatment are discussed. Para evidenciar a queda da imunidade adquirida após cura quimioterápica, um lote de camundongos foi infectado com ±25 cercárías de S. mansoni (cepa LE). Parte destes animais foi tratada aos 120 dias com 400 mg/kg de oxamniquina. Foram feitos desafios em intervalos de 45, 90 e 170 dias após o tratamento (185, 210 e 290 dias após a primoinfecção, respectivamente). A recuperação aos 20 dias após as infecções desafio, dos vermes das reinfecções mostrou que a imunidade residual persiste até os 90 dias após o tratamento e desaparece aos 170 dias após a cura. Com o soro dos camundongos, através do método de ELISA, evidenciou-se uma queda nos níveis de anticorpos (IgG total) no grupo tratado em relação a vários antígenos de estágios evolutivos do S. mansoni. As implicações epidemiológicas dos presentes resultados e os possíveis mecanismos envolvidos na queda da imunidade adquirida após tratamento são discutidos. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 35 4 337 344 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Fernando Schemelzer de Moraes Bezerra Paulo Marcos Zech Coelho Carlos Alberto Pereira Tavares Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
topic_facet |
Schistosoma mansoni Chemotherapy Residual immunity Concomitant immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possible to detect a decrease of antibody levels (total IgG) in the treated group, when antigens from different evolutive stages of S. mansoni were used. The epidemiological implications of the present results, and the possible mechanisms involved in the decrease of acquired immunity after treatment are discussed. Para evidenciar a queda da imunidade adquirida após cura quimioterápica, um lote de camundongos foi infectado com ±25 cercárías de S. mansoni (cepa LE). Parte destes animais foi tratada aos 120 dias com 400 mg/kg de oxamniquina. Foram feitos desafios em intervalos de 45, 90 e 170 dias após o tratamento (185, 210 e 290 dias após a primoinfecção, respectivamente). A recuperação aos 20 dias após as infecções desafio, dos vermes das reinfecções mostrou que a imunidade residual persiste até os 90 dias após o tratamento e desaparece aos 170 dias após a cura. Com o soro dos camundongos, através do método de ELISA, evidenciou-se uma queda nos níveis de anticorpos (IgG total) no grupo tratado em relação a vários antígenos de estágios evolutivos do S. mansoni. As implicações epidemiológicas dos presentes resultados e os possíveis mecanismos envolvidos na queda da imunidade adquirida após tratamento são discutidos. |
format |
Article in Journal/Newspaper |
author |
Fernando Schemelzer de Moraes Bezerra Paulo Marcos Zech Coelho Carlos Alberto Pereira Tavares |
author_facet |
Fernando Schemelzer de Moraes Bezerra Paulo Marcos Zech Coelho Carlos Alberto Pereira Tavares |
author_sort |
Fernando Schemelzer de Moraes Bezerra |
title |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
title_short |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
title_full |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
title_fullStr |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
title_full_unstemmed |
Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease Schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
title_sort |
schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease schistosoma mansoni: imunidade protetora em camundongos curados por quimioterapia na fase crônica da doença |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1993 |
url |
https://doi.org/10.1590/S0036-46651993000400006 https://doaj.org/article/a74dcaeb78eb44d4be6d8e5e7183fef9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 35, Iss 4, Pp 337-344 (1993) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000400006 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651993000400006 0036-4665 1678-9946 https://doaj.org/article/a74dcaeb78eb44d4be6d8e5e7183fef9 |
op_doi |
https://doi.org/10.1590/S0036-46651993000400006 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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35 |
container_issue |
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337 |
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344 |
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