Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe
OBJECTIVES: To estimate the costs, benefits and cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries: Argentina, Brazil, Chile, the Dominican Republic, Honduras, Mexico, Panama, and Venezuela. METHODS: An economic model was constructed to es...
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Pan American Health Organization
2007
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ftdoajarticles:oai:doaj.org/article:a72104e4370e4500b4dc8063c5585531 2023-05-15T15:18:16+02:00 Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe Richard D. Rheingans Dagna Constenla Lynn Antil Bruce L. Innis Thomas Breuer 2007-04-01T00:00:00Z https://doaj.org/article/a72104e4370e4500b4dc8063c5585531 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892007000300003 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/a72104e4370e4500b4dc8063c5585531 Revista Panamericana de Salud Pública, Vol 21, Iss 4, Pp 205-216 (2007) Rotavirus vacunas contra rotavirus análisis costo-beneficio modelos económicos América Latina Región del Caribe rotavirus vaccines cost-benefit analysis models economic Latin America Caribbean Region Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2007 ftdoajarticles 2022-12-31T14:25:19Z OBJECTIVES: To estimate the costs, benefits and cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries: Argentina, Brazil, Chile, the Dominican Republic, Honduras, Mexico, Panama, and Venezuela. METHODS: An economic model was constructed to estimate the cost-effectiveness of vaccination from the health care system perspective, using national administrative and published epidemiological evidence, country-specific cost estimates, and vaccine efficacy data. The model was applied to the first five years of life for the 2003 birth cohort in each country. The main health outcome was the disability-adjusted life year (DALY), and the main summary measure was the incremental cost per DALY averted. A 3% discount rate was used for all predicted costs and benefits. Sensitivity analyses evaluated the impact of uncertainty regarding key variables on cost-effectiveness estimates. RESULTS: According to the estimates obtained with the economic model, vaccination would prevent more than 65% of the medical visits, deaths, and treatment costs associated with rotavirus gastroenteritis in the eight countries analyzed here. At a cost of US$ 24 per course (for a two-dose vaccine), the incremental cost-effectiveness ratio ranged from US$ 269/DALY in Honduras to US$ 10 656/DALY in Chile. Cost-effectiveness ratios were sensitive to assumptions about vaccine price, mortality, and vaccine efficacy. CONCLUSIONS: Vaccination would effectively reduce the disease burden and health care costs of rotavirus gastroenteritis in the Latin American and Caribbean countries analyzed here. From the health care system perspective, universal vaccination of infants is predicted to be cost-effective, based on current standards. OBJETIVOS: Estimar los costos, los beneficios y la efectividad en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe: Argentina, Brasil, Chile, Honduras, México, Panamá, República Dominicana y Venezuela. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina Daly ENVELOPE(63.761,63.761,-67.513,-67.513) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Rotavirus vacunas contra rotavirus análisis costo-beneficio modelos económicos América Latina Región del Caribe rotavirus vaccines cost-benefit analysis models economic Latin America Caribbean Region Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Rotavirus vacunas contra rotavirus análisis costo-beneficio modelos económicos América Latina Región del Caribe rotavirus vaccines cost-benefit analysis models economic Latin America Caribbean Region Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Richard D. Rheingans Dagna Constenla Lynn Antil Bruce L. Innis Thomas Breuer Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe |
topic_facet |
Rotavirus vacunas contra rotavirus análisis costo-beneficio modelos económicos América Latina Región del Caribe rotavirus vaccines cost-benefit analysis models economic Latin America Caribbean Region Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVES: To estimate the costs, benefits and cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries: Argentina, Brazil, Chile, the Dominican Republic, Honduras, Mexico, Panama, and Venezuela. METHODS: An economic model was constructed to estimate the cost-effectiveness of vaccination from the health care system perspective, using national administrative and published epidemiological evidence, country-specific cost estimates, and vaccine efficacy data. The model was applied to the first five years of life for the 2003 birth cohort in each country. The main health outcome was the disability-adjusted life year (DALY), and the main summary measure was the incremental cost per DALY averted. A 3% discount rate was used for all predicted costs and benefits. Sensitivity analyses evaluated the impact of uncertainty regarding key variables on cost-effectiveness estimates. RESULTS: According to the estimates obtained with the economic model, vaccination would prevent more than 65% of the medical visits, deaths, and treatment costs associated with rotavirus gastroenteritis in the eight countries analyzed here. At a cost of US$ 24 per course (for a two-dose vaccine), the incremental cost-effectiveness ratio ranged from US$ 269/DALY in Honduras to US$ 10 656/DALY in Chile. Cost-effectiveness ratios were sensitive to assumptions about vaccine price, mortality, and vaccine efficacy. CONCLUSIONS: Vaccination would effectively reduce the disease burden and health care costs of rotavirus gastroenteritis in the Latin American and Caribbean countries analyzed here. From the health care system perspective, universal vaccination of infants is predicted to be cost-effective, based on current standards. OBJETIVOS: Estimar los costos, los beneficios y la efectividad en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe: Argentina, Brasil, Chile, Honduras, México, Panamá, República Dominicana y Venezuela. ... |
format |
Article in Journal/Newspaper |
author |
Richard D. Rheingans Dagna Constenla Lynn Antil Bruce L. Innis Thomas Breuer |
author_facet |
Richard D. Rheingans Dagna Constenla Lynn Antil Bruce L. Innis Thomas Breuer |
author_sort |
Richard D. Rheingans |
title |
Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe |
title_short |
Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe |
title_full |
Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe |
title_fullStr |
Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe |
title_full_unstemmed |
Potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American and Caribbean countries Efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de América Latina y el Caribe |
title_sort |
potential cost-effectiveness of vaccination for rotavirus gastroenteritis in eight latin american and caribbean countries efectividad potencial en función del costo de la vacunación contra la gastroenteritis por rotavirus en ocho países de américa latina y el caribe |
publisher |
Pan American Health Organization |
publishDate |
2007 |
url |
https://doaj.org/article/a72104e4370e4500b4dc8063c5585531 |
long_lat |
ENVELOPE(63.761,63.761,-67.513,-67.513) |
geographic |
Arctic Argentina Daly |
geographic_facet |
Arctic Argentina Daly |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 21, Iss 4, Pp 205-216 (2007) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892007000300003 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/a72104e4370e4500b4dc8063c5585531 |
_version_ |
1766348478077730816 |