Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy?
Background. Asymptomatic carriage of the malaria parasites, likewise its misdiagnosis, especially false negatives, due to the use of substandard rapid diagnosis tests (RDTs) has been shown to hinder the progress of the fight against malaria. Method. The study assessed the prevalence of asymptomatic...
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ftdoajarticles:oai:doaj.org/article:a7194072293e4e17b70f2a17d73c8314 2023-05-15T15:07:40+02:00 Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? Osman N. Kanwugu Gideon K. Helegbe Paul A. Aryee Abass Abdul-Karim Frank Anaba Zulka Ziblim Evans D. Amevi 2019-01-01T00:00:00Z https://doi.org/10.1155/2019/6457628 https://doaj.org/article/a7194072293e4e17b70f2a17d73c8314 EN eng Hindawi Limited http://dx.doi.org/10.1155/2019/6457628 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2019/6457628 https://doaj.org/article/a7194072293e4e17b70f2a17d73c8314 Journal of Tropical Medicine, Vol 2019 (2019) Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1155/2019/6457628 2022-12-30T21:03:35Z Background. Asymptomatic carriage of the malaria parasites, likewise its misdiagnosis, especially false negatives, due to the use of substandard rapid diagnosis tests (RDTs) has been shown to hinder the progress of the fight against malaria. Method. The study assessed the prevalence of asymptomatic malaria as well as the performance of Plasmodium falciparum-specific protein and histidine-rich protein 2 (PfHRP2) CareStart™ RDT against standard microscopy in the detection of malaria infection among 345 children (1–15 yrs) from two (2) basic schools in Tamale Metropolis. Results. From the microscopy (considered as gold standard), prevalence of malaria among the asymptomatic children was found to be 2.6%, with sensitivity and specificity of CareStart™ RDT in detecting P. falciparum infections found to be 55.6% and 93.8%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) of CareStart™ RDT were found to be 19.23% and 98.45%, respectively. There was an evidence showing a significant relation between CareStart™ RDT and microscopy in determining malaria infection (χ2 = 30.579, p<0.001). Conclusion. Prevalence of asymptomatic malaria among children was found to be 2.6%. The study reported low sensitivity and PPV for PfHRP2 CareStart™ RDT in an asymptomatic population at instances of low parasitaemia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2019 1 7 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Osman N. Kanwugu Gideon K. Helegbe Paul A. Aryee Abass Abdul-Karim Frank Anaba Zulka Ziblim Evans D. Amevi Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Asymptomatic carriage of the malaria parasites, likewise its misdiagnosis, especially false negatives, due to the use of substandard rapid diagnosis tests (RDTs) has been shown to hinder the progress of the fight against malaria. Method. The study assessed the prevalence of asymptomatic malaria as well as the performance of Plasmodium falciparum-specific protein and histidine-rich protein 2 (PfHRP2) CareStart™ RDT against standard microscopy in the detection of malaria infection among 345 children (1–15 yrs) from two (2) basic schools in Tamale Metropolis. Results. From the microscopy (considered as gold standard), prevalence of malaria among the asymptomatic children was found to be 2.6%, with sensitivity and specificity of CareStart™ RDT in detecting P. falciparum infections found to be 55.6% and 93.8%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) of CareStart™ RDT were found to be 19.23% and 98.45%, respectively. There was an evidence showing a significant relation between CareStart™ RDT and microscopy in determining malaria infection (χ2 = 30.579, p<0.001). Conclusion. Prevalence of asymptomatic malaria among children was found to be 2.6%. The study reported low sensitivity and PPV for PfHRP2 CareStart™ RDT in an asymptomatic population at instances of low parasitaemia. |
format |
Article in Journal/Newspaper |
author |
Osman N. Kanwugu Gideon K. Helegbe Paul A. Aryee Abass Abdul-Karim Frank Anaba Zulka Ziblim Evans D. Amevi |
author_facet |
Osman N. Kanwugu Gideon K. Helegbe Paul A. Aryee Abass Abdul-Karim Frank Anaba Zulka Ziblim Evans D. Amevi |
author_sort |
Osman N. Kanwugu |
title |
Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? |
title_short |
Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? |
title_full |
Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? |
title_fullStr |
Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? |
title_full_unstemmed |
Prevalence of Asymptomatic Malaria among Children in the Tamale Metropolis: How Does the PfHRP2 CareStart™ RDT Perform against Microscopy? |
title_sort |
prevalence of asymptomatic malaria among children in the tamale metropolis: how does the pfhrp2 carestart™ rdt perform against microscopy? |
publisher |
Hindawi Limited |
publishDate |
2019 |
url |
https://doi.org/10.1155/2019/6457628 https://doaj.org/article/a7194072293e4e17b70f2a17d73c8314 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2019 (2019) |
op_relation |
http://dx.doi.org/10.1155/2019/6457628 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2019/6457628 https://doaj.org/article/a7194072293e4e17b70f2a17d73c8314 |
op_doi |
https://doi.org/10.1155/2019/6457628 |
container_title |
Journal of Tropical Medicine |
container_volume |
2019 |
container_start_page |
1 |
op_container_end_page |
7 |
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1766339116538003456 |