Effects of Brazilian scorpion venoms on the central nervous system
Abstract In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus, T. silvestres, T. brazilae, T. confluens, T. cos...
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ftdoajarticles:oai:doaj.org/article:a71317dfba964d60b6258c37651e1d2b 2023-05-15T15:10:59+02:00 Effects of Brazilian scorpion venoms on the central nervous system Ana Leonor Abrahão Nencioni Emidio Beraldo Neto Lucas Alves de Freitas Valquiria Abrão Coronado Dorce 2018-02-01T00:00:00Z https://doi.org/10.1186/s40409-018-0139-x https://doaj.org/article/a71317dfba964d60b6258c37651e1d2b EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100202&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-018-0139-x https://doaj.org/article/a71317dfba964d60b6258c37651e1d2b Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 0 (2018) Brazilian scorpions Central nervous system Scorpion venom Scorpion toxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2018 ftdoajarticles https://doi.org/10.1186/s40409-018-0139-x 2022-12-31T09:08:52Z Abstract In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus, T. silvestres, T. brazilae, T. confluens, T. costatus, T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system. On the other hand, some evidence show the participation of the central nervous system and inflammatory response in the process. The participation of the central nervous system in envenoming has always been questioned. Some authors claim that the central effects would be a consequence of peripheral stimulation and would be the result, not the cause, of the envenoming process. Because, they say, at least in adult individuals, the venom would be unable to cross the blood-brain barrier. In contrast, there is some evidence showing the direct participation of the central nervous system in the envenoming process. This review summarizes the major findings on the effects of Brazilian scorpion venoms on the central nervous system, both clinically and experimentally. Most of the studies have been performed with T. serrulatus and T. bahiensis. Little information is available regarding the other Brazilian Tityus species. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 24 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Brazilian scorpions Central nervous system Scorpion venom Scorpion toxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Brazilian scorpions Central nervous system Scorpion venom Scorpion toxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Ana Leonor Abrahão Nencioni Emidio Beraldo Neto Lucas Alves de Freitas Valquiria Abrão Coronado Dorce Effects of Brazilian scorpion venoms on the central nervous system |
topic_facet |
Brazilian scorpions Central nervous system Scorpion venom Scorpion toxins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus, T. silvestres, T. brazilae, T. confluens, T. costatus, T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system. On the other hand, some evidence show the participation of the central nervous system and inflammatory response in the process. The participation of the central nervous system in envenoming has always been questioned. Some authors claim that the central effects would be a consequence of peripheral stimulation and would be the result, not the cause, of the envenoming process. Because, they say, at least in adult individuals, the venom would be unable to cross the blood-brain barrier. In contrast, there is some evidence showing the direct participation of the central nervous system in the envenoming process. This review summarizes the major findings on the effects of Brazilian scorpion venoms on the central nervous system, both clinically and experimentally. Most of the studies have been performed with T. serrulatus and T. bahiensis. Little information is available regarding the other Brazilian Tityus species. |
format |
Article in Journal/Newspaper |
author |
Ana Leonor Abrahão Nencioni Emidio Beraldo Neto Lucas Alves de Freitas Valquiria Abrão Coronado Dorce |
author_facet |
Ana Leonor Abrahão Nencioni Emidio Beraldo Neto Lucas Alves de Freitas Valquiria Abrão Coronado Dorce |
author_sort |
Ana Leonor Abrahão Nencioni |
title |
Effects of Brazilian scorpion venoms on the central nervous system |
title_short |
Effects of Brazilian scorpion venoms on the central nervous system |
title_full |
Effects of Brazilian scorpion venoms on the central nervous system |
title_fullStr |
Effects of Brazilian scorpion venoms on the central nervous system |
title_full_unstemmed |
Effects of Brazilian scorpion venoms on the central nervous system |
title_sort |
effects of brazilian scorpion venoms on the central nervous system |
publisher |
SciELO |
publishDate |
2018 |
url |
https://doi.org/10.1186/s40409-018-0139-x https://doaj.org/article/a71317dfba964d60b6258c37651e1d2b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 0 (2018) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100202&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-018-0139-x https://doaj.org/article/a71317dfba964d60b6258c37651e1d2b |
op_doi |
https://doi.org/10.1186/s40409-018-0139-x |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
24 |
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1 |
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1766341905047617536 |