Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection
Abstract Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an important pathogenic mechanism in sev...
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ftdoajarticles:oai:doaj.org/article:a70d3c0bb8f34de8881f93313f1c172d 2023-05-15T15:11:18+02:00 Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection Damian A. Oyong Jessica R. Loughland Arya SheelaNair Dean Andrew Fabian D. L. Rivera Kim A. Piera Timothy William Matthew J. Grigg Bridget E. Barber Ashraful Haque Christian R. Engwerda James S. McCarthy Nicholas M. Anstey Michelle J. Boyle 2019-09-01T00:00:00Z https://doi.org/10.1186/s12936-019-2962-0 https://doaj.org/article/a70d3c0bb8f34de8881f93313f1c172d EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2962-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2962-0 1475-2875 https://doaj.org/article/a70d3c0bb8f34de8881f93313f1c172d Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019) Malaria Anaemia Complement Complement regulatory proteins falciparum vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2962-0 2022-12-31T13:23:13Z Abstract Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an important pathogenic mechanism in severe malarial anaemia in both Plasmodium falciparum and Plasmodium vivax infection. However, little is known about loss of CRPs on RBCs during mild malarial anaemia and in low-density infection. Methods The expression of CRP CR1, CD55, CD59, and the phagocytic regulator CD47, on uninfected normocytes and reticulocytes were assessed in individuals from two study populations: (1) P. falciparum and P. vivax-infected patients from a low transmission setting in Sabah, Malaysia; and, (2) malaria-naïve volunteers undergoing P. falciparum induced blood-stage malaria (IBSM). For clinical infections, individuals were categorized into anaemia severity categories based on haemoglobin levels. For IBSM, associations between CRPs and haemoglobin level were investigated. Results CRP expression on RBC was lower in Malaysian individuals with P. falciparum and P. vivax mild malarial anaemia compared to healthy controls. CRP expression was also reduced on RBCs from volunteers during IBSM. Reduction occurred on normocytes and reticulocytes. However, there was no significant association between reduced CRPs and haemoglobin during IBSM. Conclusions Removal of CRPs occurs on both RBCs and reticulocytes during Plasmodium infection even in mild malarial anaemia and at low levels of parasitaemia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Anaemia Complement Complement regulatory proteins falciparum vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Anaemia Complement Complement regulatory proteins falciparum vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Damian A. Oyong Jessica R. Loughland Arya SheelaNair Dean Andrew Fabian D. L. Rivera Kim A. Piera Timothy William Matthew J. Grigg Bridget E. Barber Ashraful Haque Christian R. Engwerda James S. McCarthy Nicholas M. Anstey Michelle J. Boyle Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection |
topic_facet |
Malaria Anaemia Complement Complement regulatory proteins falciparum vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an important pathogenic mechanism in severe malarial anaemia in both Plasmodium falciparum and Plasmodium vivax infection. However, little is known about loss of CRPs on RBCs during mild malarial anaemia and in low-density infection. Methods The expression of CRP CR1, CD55, CD59, and the phagocytic regulator CD47, on uninfected normocytes and reticulocytes were assessed in individuals from two study populations: (1) P. falciparum and P. vivax-infected patients from a low transmission setting in Sabah, Malaysia; and, (2) malaria-naïve volunteers undergoing P. falciparum induced blood-stage malaria (IBSM). For clinical infections, individuals were categorized into anaemia severity categories based on haemoglobin levels. For IBSM, associations between CRPs and haemoglobin level were investigated. Results CRP expression on RBC was lower in Malaysian individuals with P. falciparum and P. vivax mild malarial anaemia compared to healthy controls. CRP expression was also reduced on RBCs from volunteers during IBSM. Reduction occurred on normocytes and reticulocytes. However, there was no significant association between reduced CRPs and haemoglobin during IBSM. Conclusions Removal of CRPs occurs on both RBCs and reticulocytes during Plasmodium infection even in mild malarial anaemia and at low levels of parasitaemia. |
format |
Article in Journal/Newspaper |
author |
Damian A. Oyong Jessica R. Loughland Arya SheelaNair Dean Andrew Fabian D. L. Rivera Kim A. Piera Timothy William Matthew J. Grigg Bridget E. Barber Ashraful Haque Christian R. Engwerda James S. McCarthy Nicholas M. Anstey Michelle J. Boyle |
author_facet |
Damian A. Oyong Jessica R. Loughland Arya SheelaNair Dean Andrew Fabian D. L. Rivera Kim A. Piera Timothy William Matthew J. Grigg Bridget E. Barber Ashraful Haque Christian R. Engwerda James S. McCarthy Nicholas M. Anstey Michelle J. Boyle |
author_sort |
Damian A. Oyong |
title |
Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection |
title_short |
Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection |
title_full |
Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection |
title_fullStr |
Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection |
title_full_unstemmed |
Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection |
title_sort |
loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in plasmodium falciparum induced blood-stage infection |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2962-0 https://doaj.org/article/a70d3c0bb8f34de8881f93313f1c172d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2962-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2962-0 1475-2875 https://doaj.org/article/a70d3c0bb8f34de8881f93313f1c172d |
op_doi |
https://doi.org/10.1186/s12936-019-2962-0 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766342173585833984 |