Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study.
BACKGROUND:The effectiveness of anti-parasite treatment with benznidazole in the chronic Chagas disease (ChD) remains uncertain. We evaluated, using data from the NIH-sponsored SaMi-Trop prospective cohort study, if previous treatment with benznidazole is associated with lower mortality, less advanc...
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ftdoajarticles:oai:doaj.org/article:a70539306698432a8f1122a164cfa6db 2023-05-15T15:12:51+02:00 Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. Clareci Silva Cardoso Antonio Luiz P Ribeiro Claudia Di Lorenzo Oliveira Lea Campos Oliveira Ariela Mota Ferreira Ana Luiza Bierrenbach José Luiz Padilha Silva Enrico Antonio Colosimo João Eduardo Ferreira Tzong-Hae Lee Michael P Busch Arthur Lawrence Reingold Ester Cerdeira Sabino 2018-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006814 https://doaj.org/article/a70539306698432a8f1122a164cfa6db EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6211620?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006814 https://doaj.org/article/a70539306698432a8f1122a164cfa6db PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006814 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006814 2022-12-31T02:02:56Z BACKGROUND:The effectiveness of anti-parasite treatment with benznidazole in the chronic Chagas disease (ChD) remains uncertain. We evaluated, using data from the NIH-sponsored SaMi-Trop prospective cohort study, if previous treatment with benznidazole is associated with lower mortality, less advanced cardiac disease and lower parasitemia in patients with chronic ChD. METHODS:The study enrolled 1,959 ChD patients and abnormal electrocardiogram (ECG) from in 21 remote towns in Brazil. A total of 1,813 patients were evaluated at baseline and after two years of follow-up. Those who received at least one course of benznidazole were classified as treated group (TrG = 493) and those who were never treated as control group (CG = 1,320). The primary outcome was death after two-year follow-up; the secondary outcomes were presence at the baseline of major ChD-associated ECG abnormalities, NT-ProBNP levels suggestive of heart failure, and PCR positivity. RESULTS:Mortality after two years was 6.3%; it was lower in the TrG (2.8%) than the CG (7.6%); adjusted OR: 0.37 (95%CI: 0.21;0.63). The ECG abnormalities typical for ChD and high age-adjusted NT-ProBNP levels suggestive of heart failure were lower in the TrG than the CG, OR: 0.35 [CI: 0.23;0.53]. The TrG had significantly lower rates of PCR positivity, OR: 0.35 [CI: 0.27;0.45]. CONCLUSION:Patients previously treated with benznidazole had significantly reduced parasitemia, a lower prevalence of markers of severe cardiomyopathy, and lower mortality after two years of follow-up. If used in the early phases, benznidazole treatment may improve clinical and parasitological outcomes in patients with chronic ChD. TRIAL REGISTRATION:ClinicalTrials.gov, Trial registration: NCT02646943. Article in Journal/Newspaper Arctic sami Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 11 e0006814 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Clareci Silva Cardoso Antonio Luiz P Ribeiro Claudia Di Lorenzo Oliveira Lea Campos Oliveira Ariela Mota Ferreira Ana Luiza Bierrenbach José Luiz Padilha Silva Enrico Antonio Colosimo João Eduardo Ferreira Tzong-Hae Lee Michael P Busch Arthur Lawrence Reingold Ester Cerdeira Sabino Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The effectiveness of anti-parasite treatment with benznidazole in the chronic Chagas disease (ChD) remains uncertain. We evaluated, using data from the NIH-sponsored SaMi-Trop prospective cohort study, if previous treatment with benznidazole is associated with lower mortality, less advanced cardiac disease and lower parasitemia in patients with chronic ChD. METHODS:The study enrolled 1,959 ChD patients and abnormal electrocardiogram (ECG) from in 21 remote towns in Brazil. A total of 1,813 patients were evaluated at baseline and after two years of follow-up. Those who received at least one course of benznidazole were classified as treated group (TrG = 493) and those who were never treated as control group (CG = 1,320). The primary outcome was death after two-year follow-up; the secondary outcomes were presence at the baseline of major ChD-associated ECG abnormalities, NT-ProBNP levels suggestive of heart failure, and PCR positivity. RESULTS:Mortality after two years was 6.3%; it was lower in the TrG (2.8%) than the CG (7.6%); adjusted OR: 0.37 (95%CI: 0.21;0.63). The ECG abnormalities typical for ChD and high age-adjusted NT-ProBNP levels suggestive of heart failure were lower in the TrG than the CG, OR: 0.35 [CI: 0.23;0.53]. The TrG had significantly lower rates of PCR positivity, OR: 0.35 [CI: 0.27;0.45]. CONCLUSION:Patients previously treated with benznidazole had significantly reduced parasitemia, a lower prevalence of markers of severe cardiomyopathy, and lower mortality after two years of follow-up. If used in the early phases, benznidazole treatment may improve clinical and parasitological outcomes in patients with chronic ChD. TRIAL REGISTRATION:ClinicalTrials.gov, Trial registration: NCT02646943. |
format |
Article in Journal/Newspaper |
author |
Clareci Silva Cardoso Antonio Luiz P Ribeiro Claudia Di Lorenzo Oliveira Lea Campos Oliveira Ariela Mota Ferreira Ana Luiza Bierrenbach José Luiz Padilha Silva Enrico Antonio Colosimo João Eduardo Ferreira Tzong-Hae Lee Michael P Busch Arthur Lawrence Reingold Ester Cerdeira Sabino |
author_facet |
Clareci Silva Cardoso Antonio Luiz P Ribeiro Claudia Di Lorenzo Oliveira Lea Campos Oliveira Ariela Mota Ferreira Ana Luiza Bierrenbach José Luiz Padilha Silva Enrico Antonio Colosimo João Eduardo Ferreira Tzong-Hae Lee Michael P Busch Arthur Lawrence Reingold Ester Cerdeira Sabino |
author_sort |
Clareci Silva Cardoso |
title |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. |
title_short |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. |
title_full |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. |
title_fullStr |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. |
title_full_unstemmed |
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. |
title_sort |
beneficial effects of benznidazole in chagas disease: nih sami-trop cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006814 https://doaj.org/article/a70539306698432a8f1122a164cfa6db |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic sami |
genre_facet |
Arctic sami |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006814 (2018) |
op_relation |
http://europepmc.org/articles/PMC6211620?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006814 https://doaj.org/article/a70539306698432a8f1122a164cfa6db |
op_doi |
https://doi.org/10.1371/journal.pntd.0006814 |
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PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
11 |
container_start_page |
e0006814 |
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