The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV.
Background Brazil remains endemic for infection by the human immunodeficiency virus (HIV) and leprosy, having a major impact on public health and the life quality of affected patients. Although the relevance of this co-infection is recognized, several aspects, such as the immune response, are not ye...
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ftdoajarticles:oai:doaj.org/article:a6f4da389bd846a7b94f390b3e068118 2023-05-15T15:16:22+02:00 The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. Marília Brasil Xavier Carla Andréa Avelar Pires Cláudia Maria de Castro Gomes Gabriela Fernandes Rodrigues Débora Pinheiro Xavier João Augusto Gomes de Souza Monteiro de Brito Carlos Eduardo Pereira Corbett 2021-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009887 https://doaj.org/article/a6f4da389bd846a7b94f390b3e068118 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009887 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009887 https://doaj.org/article/a6f4da389bd846a7b94f390b3e068118 PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009887 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009887 2022-12-31T10:57:23Z Background Brazil remains endemic for infection by the human immunodeficiency virus (HIV) and leprosy, having a major impact on public health and the life quality of affected patients. Although the relevance of this co-infection is recognized, several aspects, such as the immune response, are not yet fully understood. The objective of this study was to investigate the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics (CD4, CD8, and CV), and the immune reconstitution syndrome in HIV-leprosy co-infection. Methodology/principal findings An observational, cross-sectional, and analytical study was carried out comparing four groups of patients: those with concomitant diagnosis of leprosy and HIV infection without a leprosy reaction, those with leprosy and HIV co-infection patients with a reverse reaction (RR), those with leprosy without HIV and without reaction, and those with leprosywithout HIV and with RR. The patients were diagnosed at a dermatology outpatient clinic located in Belém, Pará, Brazil, from 2003 to 2017. In the sample studied, there was a positive correlation between FOXP3+ cell density and viral load, negative correlation with blood CD4+ (not statistically significant), significant positive correlation in CD8 count in patients with leprosy reaction, and positive relationship in patients with IRIS. The density of cells expressing FOXP3 was higher in the BL/LL forms in patients without HIV, although the difference was not statistically significant. However, the cell mean was higher in the TT/BT forms in patients co-infected with leprosy and HIV, showing contradictory results. Conclusions/significance These findings support that higher activity of the HIV may stimulate or result in a higher expression of FOXP3-Tregs and that they may be involved in active immunosuppression observed at the infection site at the tissue level. This supports the need to expand studies on FOXP3+ Treg cells in co-infected patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 11 e0009887 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Marília Brasil Xavier Carla Andréa Avelar Pires Cláudia Maria de Castro Gomes Gabriela Fernandes Rodrigues Débora Pinheiro Xavier João Augusto Gomes de Souza Monteiro de Brito Carlos Eduardo Pereira Corbett The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Brazil remains endemic for infection by the human immunodeficiency virus (HIV) and leprosy, having a major impact on public health and the life quality of affected patients. Although the relevance of this co-infection is recognized, several aspects, such as the immune response, are not yet fully understood. The objective of this study was to investigate the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics (CD4, CD8, and CV), and the immune reconstitution syndrome in HIV-leprosy co-infection. Methodology/principal findings An observational, cross-sectional, and analytical study was carried out comparing four groups of patients: those with concomitant diagnosis of leprosy and HIV infection without a leprosy reaction, those with leprosy and HIV co-infection patients with a reverse reaction (RR), those with leprosy without HIV and without reaction, and those with leprosywithout HIV and with RR. The patients were diagnosed at a dermatology outpatient clinic located in Belém, Pará, Brazil, from 2003 to 2017. In the sample studied, there was a positive correlation between FOXP3+ cell density and viral load, negative correlation with blood CD4+ (not statistically significant), significant positive correlation in CD8 count in patients with leprosy reaction, and positive relationship in patients with IRIS. The density of cells expressing FOXP3 was higher in the BL/LL forms in patients without HIV, although the difference was not statistically significant. However, the cell mean was higher in the TT/BT forms in patients co-infected with leprosy and HIV, showing contradictory results. Conclusions/significance These findings support that higher activity of the HIV may stimulate or result in a higher expression of FOXP3-Tregs and that they may be involved in active immunosuppression observed at the infection site at the tissue level. This supports the need to expand studies on FOXP3+ Treg cells in co-infected patients. |
format |
Article in Journal/Newspaper |
author |
Marília Brasil Xavier Carla Andréa Avelar Pires Cláudia Maria de Castro Gomes Gabriela Fernandes Rodrigues Débora Pinheiro Xavier João Augusto Gomes de Souza Monteiro de Brito Carlos Eduardo Pereira Corbett |
author_facet |
Marília Brasil Xavier Carla Andréa Avelar Pires Cláudia Maria de Castro Gomes Gabriela Fernandes Rodrigues Débora Pinheiro Xavier João Augusto Gomes de Souza Monteiro de Brito Carlos Eduardo Pereira Corbett |
author_sort |
Marília Brasil Xavier |
title |
The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. |
title_short |
The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. |
title_full |
The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. |
title_fullStr |
The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. |
title_full_unstemmed |
The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV. |
title_sort |
expression of foxp3 in lesions of several forms of leprosy in patients co-infected with hiv. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009887 https://doaj.org/article/a6f4da389bd846a7b94f390b3e068118 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009887 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009887 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009887 https://doaj.org/article/a6f4da389bd846a7b94f390b3e068118 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009887 |
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PLOS Neglected Tropical Diseases |
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15 |
container_issue |
11 |
container_start_page |
e0009887 |
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