Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar
Abstract Background As the prevalence of the malaria has been decreasing in many endemic countries including Myanmar, malaria elimination in Greater Mekong Region was targeted not later than 2030. The relevance of molecular and serological tools to identify residual transmission remains to be establ...
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ftdoajarticles:oai:doaj.org/article:a6d3ce6c39294b0cbda35f30bce104b9 2023-05-15T15:11:45+02:00 Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar Myat Htut Nyunt Than Naing Soe Thinzar Shein Ni Ni Zaw Soe Soe Han Fauzi Muh Seong-Kyun Lee Jin-Hee Han Ji-Hoon Park Kwon-Soo Ha Won Sun Park Seok-Ho Hong Myat Phone Kyaw Eun-Taek Han 2018-01-01T00:00:00Z https://doi.org/10.1186/s12936-017-2170-8 https://doaj.org/article/a6d3ce6c39294b0cbda35f30bce104b9 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-2170-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2170-8 1475-2875 https://doaj.org/article/a6d3ce6c39294b0cbda35f30bce104b9 Malaria Journal, Vol 17, Iss 1, Pp 1-9 (2018) Malaria Serological surveillance Asymptomatic cases Myanmar Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-017-2170-8 2022-12-31T08:13:33Z Abstract Background As the prevalence of the malaria has been decreasing in many endemic countries including Myanmar, malaria elimination in Greater Mekong Region was targeted not later than 2030. The relevance of molecular and serological tools to identify residual transmission remains to be established in this setting. Methods One-year cohort study was conducted and sera samples were collected in every 3 months with active and passive case detection for clinical malaria episodes by RDT, microscopy and molecular method. The sera were used to detect the malaria antibody against PfMSP1-19, PvAMA1, PvDBPII and PvMSP1-19 by protein microarray. Results Among the recruited 1182 participants, there was no RDT positive case for malaria infection although two vivax infections were detected by microscopy in initial collection. Molecular methods detected the asymptomatic cases of 28/1182 (2.37%) in first, 5/894 (0.42%) in second, 12/944 (1.02%) in third, 6/889 (0.51%) in fourth collection, respectively. Seropositivity rates against the PfMSP1-19, PvMSP1-19, PvAMA1 and PvDBPII were 73/270 (27.0%), 85/270 (31.5%), 65/270 (24.1%) and 160/270 (59.3%), respectively. PfMSP1-19 and PvMSP1-19 showed high and stable antigenicity in acute and subacute samples but declining in 1-year history samples. No cross reactivity of PfMSP1-19 and PvMSP1-19 between the two species and higher seropositivity among the asymptomatic carriers were observed. Mapping data indicated serological surveillance can detect the geographical pattern of malaria infection under low transmission setting. Conclusions These findings support that PfMSP1-19 and PvMSP1-19 are suggested for serosurveillance of the malaria especially in low transmission setting for further necessary actions have to be carried out to eliminate the malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Malaria Serological surveillance Asymptomatic cases Myanmar Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Serological surveillance Asymptomatic cases Myanmar Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Myat Htut Nyunt Than Naing Soe Thinzar Shein Ni Ni Zaw Soe Soe Han Fauzi Muh Seong-Kyun Lee Jin-Hee Han Ji-Hoon Park Kwon-Soo Ha Won Sun Park Seok-Ho Hong Myat Phone Kyaw Eun-Taek Han Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar |
topic_facet |
Malaria Serological surveillance Asymptomatic cases Myanmar Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background As the prevalence of the malaria has been decreasing in many endemic countries including Myanmar, malaria elimination in Greater Mekong Region was targeted not later than 2030. The relevance of molecular and serological tools to identify residual transmission remains to be established in this setting. Methods One-year cohort study was conducted and sera samples were collected in every 3 months with active and passive case detection for clinical malaria episodes by RDT, microscopy and molecular method. The sera were used to detect the malaria antibody against PfMSP1-19, PvAMA1, PvDBPII and PvMSP1-19 by protein microarray. Results Among the recruited 1182 participants, there was no RDT positive case for malaria infection although two vivax infections were detected by microscopy in initial collection. Molecular methods detected the asymptomatic cases of 28/1182 (2.37%) in first, 5/894 (0.42%) in second, 12/944 (1.02%) in third, 6/889 (0.51%) in fourth collection, respectively. Seropositivity rates against the PfMSP1-19, PvMSP1-19, PvAMA1 and PvDBPII were 73/270 (27.0%), 85/270 (31.5%), 65/270 (24.1%) and 160/270 (59.3%), respectively. PfMSP1-19 and PvMSP1-19 showed high and stable antigenicity in acute and subacute samples but declining in 1-year history samples. No cross reactivity of PfMSP1-19 and PvMSP1-19 between the two species and higher seropositivity among the asymptomatic carriers were observed. Mapping data indicated serological surveillance can detect the geographical pattern of malaria infection under low transmission setting. Conclusions These findings support that PfMSP1-19 and PvMSP1-19 are suggested for serosurveillance of the malaria especially in low transmission setting for further necessary actions have to be carried out to eliminate the malaria. |
format |
Article in Journal/Newspaper |
author |
Myat Htut Nyunt Than Naing Soe Thinzar Shein Ni Ni Zaw Soe Soe Han Fauzi Muh Seong-Kyun Lee Jin-Hee Han Ji-Hoon Park Kwon-Soo Ha Won Sun Park Seok-Ho Hong Myat Phone Kyaw Eun-Taek Han |
author_facet |
Myat Htut Nyunt Than Naing Soe Thinzar Shein Ni Ni Zaw Soe Soe Han Fauzi Muh Seong-Kyun Lee Jin-Hee Han Ji-Hoon Park Kwon-Soo Ha Won Sun Park Seok-Ho Hong Myat Phone Kyaw Eun-Taek Han |
author_sort |
Myat Htut Nyunt |
title |
Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar |
title_short |
Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar |
title_full |
Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar |
title_fullStr |
Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar |
title_full_unstemmed |
Estimation on local transmission of malaria by serological approach under low transmission setting in Myanmar |
title_sort |
estimation on local transmission of malaria by serological approach under low transmission setting in myanmar |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-017-2170-8 https://doaj.org/article/a6d3ce6c39294b0cbda35f30bce104b9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-9 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-2170-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2170-8 1475-2875 https://doaj.org/article/a6d3ce6c39294b0cbda35f30bce104b9 |
op_doi |
https://doi.org/10.1186/s12936-017-2170-8 |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
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1766342555636596736 |