Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy
Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant i...
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ftdoajarticles:oai:doaj.org/article:a6af75a623154732882e7db88389516f 2023-05-15T15:58:42+02:00 Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy Chiung-Hsiang Cheng Hsin-Ying Wu Chi-Fang Wu Tong-Rong Jan 2016-01-01T00:00:00Z https://doi.org/10.1016/j.jfda.2015.08.006 https://doaj.org/article/a6af75a623154732882e7db88389516f EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1021949815001209 https://doaj.org/toc/1021-9498 1021-9498 doi:10.1016/j.jfda.2015.08.006 https://doaj.org/article/a6af75a623154732882e7db88389516f Journal of Food and Drug Analysis, Vol 24, Iss 1, Pp 121-128 (2016) Crassostrea gigas food allergy oyster polysaccharides T helper Nutrition. Foods and food supply TX341-641 Therapeutics. Pharmacology RM1-950 article 2016 ftdoajarticles https://doi.org/10.1016/j.jfda.2015.08.006 2022-12-31T13:14:12Z Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant immune disorder. BALB/c mice were sensitized twice with ovalbumin (OVA) absorbed to alum and then repeatedly challenged with intragastric OVA to induce intestinal allergic responses. The mice were administered by gavage with OPS and/or vehicle (distilled water) once/d during the two sensitization phases, and once every other day during the challenge phase. Administration with OPS attenuated OVA challenge-elicited diarrhea, and the infiltration of mast cells in the intestine. OPS demonstrated a protective effect on the reduced ratio of villus length over crypt depth of the intestine in allergic mice. Furthermore, OPS administration markedly attenuated the intestinal expression of the Th2 signature cytokine interleukin-4 (IL-4). Collectively, these results demonstrated the in vivo antiallergic activity of OPS, which is associated with the suppression of allergen-induced intestinal Th2 responses and mast cell activation. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific Journal of Food and Drug Analysis 24 1 121 128 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Crassostrea gigas food allergy oyster polysaccharides T helper Nutrition. Foods and food supply TX341-641 Therapeutics. Pharmacology RM1-950 |
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Crassostrea gigas food allergy oyster polysaccharides T helper Nutrition. Foods and food supply TX341-641 Therapeutics. Pharmacology RM1-950 Chiung-Hsiang Cheng Hsin-Ying Wu Chi-Fang Wu Tong-Rong Jan Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
topic_facet |
Crassostrea gigas food allergy oyster polysaccharides T helper Nutrition. Foods and food supply TX341-641 Therapeutics. Pharmacology RM1-950 |
description |
Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant immune disorder. BALB/c mice were sensitized twice with ovalbumin (OVA) absorbed to alum and then repeatedly challenged with intragastric OVA to induce intestinal allergic responses. The mice were administered by gavage with OPS and/or vehicle (distilled water) once/d during the two sensitization phases, and once every other day during the challenge phase. Administration with OPS attenuated OVA challenge-elicited diarrhea, and the infiltration of mast cells in the intestine. OPS demonstrated a protective effect on the reduced ratio of villus length over crypt depth of the intestine in allergic mice. Furthermore, OPS administration markedly attenuated the intestinal expression of the Th2 signature cytokine interleukin-4 (IL-4). Collectively, these results demonstrated the in vivo antiallergic activity of OPS, which is associated with the suppression of allergen-induced intestinal Th2 responses and mast cell activation. |
format |
Article in Journal/Newspaper |
author |
Chiung-Hsiang Cheng Hsin-Ying Wu Chi-Fang Wu Tong-Rong Jan |
author_facet |
Chiung-Hsiang Cheng Hsin-Ying Wu Chi-Fang Wu Tong-Rong Jan |
author_sort |
Chiung-Hsiang Cheng |
title |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_short |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_full |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_fullStr |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_full_unstemmed |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_sort |
pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
publisher |
Elsevier |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.jfda.2015.08.006 https://doaj.org/article/a6af75a623154732882e7db88389516f |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Journal of Food and Drug Analysis, Vol 24, Iss 1, Pp 121-128 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1021949815001209 https://doaj.org/toc/1021-9498 1021-9498 doi:10.1016/j.jfda.2015.08.006 https://doaj.org/article/a6af75a623154732882e7db88389516f |
op_doi |
https://doi.org/10.1016/j.jfda.2015.08.006 |
container_title |
Journal of Food and Drug Analysis |
container_volume |
24 |
container_issue |
1 |
container_start_page |
121 |
op_container_end_page |
128 |
_version_ |
1766394467757064192 |