Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions
Abstract Background The combined effects of multiple density-dependent, regulatory processes may have an important impact on the growth and stability of a population. In a malaria model system, it has been shown that the progression of Plasmodium berghei through Anopheles stephensi and the survival...
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ftdoajarticles:oai:doaj.org/article:a66ce66e109844f2972114b424fcd3bd 2023-05-15T15:16:01+02:00 Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions Koella Jacob C Christophides George K Sinden Robert E Dawes Emma J Churcher Thomas S Basáñez María-Gloria 2010-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-311 https://doaj.org/article/a66ce66e109844f2972114b424fcd3bd EN eng BMC http://www.malariajournal.com/content/9/1/311 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-311 1475-2875 https://doaj.org/article/a66ce66e109844f2972114b424fcd3bd Malaria Journal, Vol 9, Iss 1, p 311 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-311 2022-12-31T09:15:25Z Abstract Background The combined effects of multiple density-dependent, regulatory processes may have an important impact on the growth and stability of a population. In a malaria model system, it has been shown that the progression of Plasmodium berghei through Anopheles stephensi and the survival of the mosquito both depend non-linearly on parasite density. These processes regulating the development of the malaria parasite within the mosquito may influence the success of transmission-blocking interventions (TBIs) currently under development. Methods An individual-based stochastic mathematical model is used to investigate the combined impact of these multiple regulatory processes and examine how TBIs, which target different parasite life-stages within the mosquito, may influence overall parasite transmission. Results The best parasite molecular targets will vary between different epidemiological settings. Interventions that reduce ookinete density beneath a threshold level are likely to have auxiliary benefits, as transmission would be further reduced by density-dependent processes that restrict sporogonic development at low parasite densities. TBIs which reduce parasite density but fail to clear the parasite could cause a modest increase in transmission by increasing the number of infectious bites made by a mosquito during its lifetime whilst failing to sufficiently reduce its infectivity. Interventions with a higher variance in efficacy will therefore tend to cause a greater reduction in overall transmission than a TBI with a more uniform effectiveness. Care should be taken when interpreting these results as parasite intensity values in natural parasite-vector combinations of human malaria are likely to be significantly lower than those in this model system. Conclusions A greater understanding of the development of the malaria parasite within the mosquito is required to fully evaluate the impact of TBIs. If parasite-induced vector mortality influenced the population dynamics of Plasmodium species infecting ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Koella Jacob C Christophides George K Sinden Robert E Dawes Emma J Churcher Thomas S Basáñez María-Gloria Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The combined effects of multiple density-dependent, regulatory processes may have an important impact on the growth and stability of a population. In a malaria model system, it has been shown that the progression of Plasmodium berghei through Anopheles stephensi and the survival of the mosquito both depend non-linearly on parasite density. These processes regulating the development of the malaria parasite within the mosquito may influence the success of transmission-blocking interventions (TBIs) currently under development. Methods An individual-based stochastic mathematical model is used to investigate the combined impact of these multiple regulatory processes and examine how TBIs, which target different parasite life-stages within the mosquito, may influence overall parasite transmission. Results The best parasite molecular targets will vary between different epidemiological settings. Interventions that reduce ookinete density beneath a threshold level are likely to have auxiliary benefits, as transmission would be further reduced by density-dependent processes that restrict sporogonic development at low parasite densities. TBIs which reduce parasite density but fail to clear the parasite could cause a modest increase in transmission by increasing the number of infectious bites made by a mosquito during its lifetime whilst failing to sufficiently reduce its infectivity. Interventions with a higher variance in efficacy will therefore tend to cause a greater reduction in overall transmission than a TBI with a more uniform effectiveness. Care should be taken when interpreting these results as parasite intensity values in natural parasite-vector combinations of human malaria are likely to be significantly lower than those in this model system. Conclusions A greater understanding of the development of the malaria parasite within the mosquito is required to fully evaluate the impact of TBIs. If parasite-induced vector mortality influenced the population dynamics of Plasmodium species infecting ... |
format |
Article in Journal/Newspaper |
author |
Koella Jacob C Christophides George K Sinden Robert E Dawes Emma J Churcher Thomas S Basáñez María-Gloria |
author_facet |
Koella Jacob C Christophides George K Sinden Robert E Dawes Emma J Churcher Thomas S Basáñez María-Gloria |
author_sort |
Koella Jacob C |
title |
Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
title_short |
Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
title_full |
Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
title_fullStr |
Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
title_full_unstemmed |
Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
title_sort |
population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-311 https://doaj.org/article/a66ce66e109844f2972114b424fcd3bd |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 311 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/311 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-311 1475-2875 https://doaj.org/article/a66ce66e109844f2972114b424fcd3bd |
op_doi |
https://doi.org/10.1186/1475-2875-9-311 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
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1766346341051531264 |