Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro
ABSTRACT The aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de...
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Universidade de São Paulo (USP)
2020
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ftdoajarticles:oai:doaj.org/article:a660a0a5e02549b38eb03704a1478a33 2024-09-09T19:28:08+00:00 Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro Abilene do Nascimento Gouvêa Alexandre José B. Trajano Denise L. M. Monteiro Nádia Cristina P. Rodrigues Julie Teixeira da Costa Mateus Benac Cavalcante Daniela Fortunato Auar Erika Ferraz de Gouvea Stella Regina Taquette 2020-09-01T00:00:00Z https://doi.org/10.1590/s1678-9946202062066 https://doaj.org/article/a660a0a5e02549b38eb03704a1478a33 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100230&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202062066 https://doaj.org/article/a660a0a5e02549b38eb03704a1478a33 Revista do Instituto de Medicina Tropical de São Paulo, Vol 62 (2020) Vertical infectious disease transmission HIV Pregnancy Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1590/s1678-9946202062066 2024-08-05T17:49:30Z ABSTRACT The aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de Janeiro, in the period of 2007-2018. The average age of mothers was 27 years (14-44), with 12.7% (41) of adolescents. The majority (66.8%) knew they were infected during pregnancy: 39.4% in the current pregnancy and 27.4% in a previous pregnancy. The incidence of MTCT was 2.7% in 2007-2009, 1% in 2010-2015 and 0 in 2016-2018. The viral load in the 3rd trimester of pregnancy was > 1.000 copies/mL or unknown in all mothers with positive newborns and in 19% (42/221) of mothers with negative newborns (p=0.003). The duration of antiretroviral use was > 4 weeks in 92.3% (264/286) of mothers with HIV-negative newborns and in 2 in the HIV-positive group (p=0.004). One of the 4 infected newborns and 2 of the negative ones did not use oral zidovudine (p=0.04). There was no association between amniorrhexis and MTCT (p=0.99), with the Apgar score in the 5th minute of life (p=0.96), with marital status (p=0.54), ethnicity (p=0.65), adolescence (p=0.42), mode of delivery (p=0.99), beginning of prenatal care (p=0.44) or with maternal comorbidities (p=0.48). The conclusion of the study points out that the main factors associated with MTCT are the elevated maternal viral load in the 3rd trimester, the time of use of ART and the non-administration of zidovudine for the newborns. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 62 |
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ftdoajarticles |
language |
English |
topic |
Vertical infectious disease transmission HIV Pregnancy Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Vertical infectious disease transmission HIV Pregnancy Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Abilene do Nascimento Gouvêa Alexandre José B. Trajano Denise L. M. Monteiro Nádia Cristina P. Rodrigues Julie Teixeira da Costa Mateus Benac Cavalcante Daniela Fortunato Auar Erika Ferraz de Gouvea Stella Regina Taquette Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
topic_facet |
Vertical infectious disease transmission HIV Pregnancy Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT The aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de Janeiro, in the period of 2007-2018. The average age of mothers was 27 years (14-44), with 12.7% (41) of adolescents. The majority (66.8%) knew they were infected during pregnancy: 39.4% in the current pregnancy and 27.4% in a previous pregnancy. The incidence of MTCT was 2.7% in 2007-2009, 1% in 2010-2015 and 0 in 2016-2018. The viral load in the 3rd trimester of pregnancy was > 1.000 copies/mL or unknown in all mothers with positive newborns and in 19% (42/221) of mothers with negative newborns (p=0.003). The duration of antiretroviral use was > 4 weeks in 92.3% (264/286) of mothers with HIV-negative newborns and in 2 in the HIV-positive group (p=0.004). One of the 4 infected newborns and 2 of the negative ones did not use oral zidovudine (p=0.04). There was no association between amniorrhexis and MTCT (p=0.99), with the Apgar score in the 5th minute of life (p=0.96), with marital status (p=0.54), ethnicity (p=0.65), adolescence (p=0.42), mode of delivery (p=0.99), beginning of prenatal care (p=0.44) or with maternal comorbidities (p=0.48). The conclusion of the study points out that the main factors associated with MTCT are the elevated maternal viral load in the 3rd trimester, the time of use of ART and the non-administration of zidovudine for the newborns. |
format |
Article in Journal/Newspaper |
author |
Abilene do Nascimento Gouvêa Alexandre José B. Trajano Denise L. M. Monteiro Nádia Cristina P. Rodrigues Julie Teixeira da Costa Mateus Benac Cavalcante Daniela Fortunato Auar Erika Ferraz de Gouvea Stella Regina Taquette |
author_facet |
Abilene do Nascimento Gouvêa Alexandre José B. Trajano Denise L. M. Monteiro Nádia Cristina P. Rodrigues Julie Teixeira da Costa Mateus Benac Cavalcante Daniela Fortunato Auar Erika Ferraz de Gouvea Stella Regina Taquette |
author_sort |
Abilene do Nascimento Gouvêa |
title |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_short |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_full |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_fullStr |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_full_unstemmed |
Vertical transmission of HIV from 2007 to 2018 in a reference university hospital in Rio de Janeiro |
title_sort |
vertical transmission of hiv from 2007 to 2018 in a reference university hospital in rio de janeiro |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2020 |
url |
https://doi.org/10.1590/s1678-9946202062066 https://doaj.org/article/a660a0a5e02549b38eb03704a1478a33 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 62 (2020) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100230&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202062066 https://doaj.org/article/a660a0a5e02549b38eb03704a1478a33 |
op_doi |
https://doi.org/10.1590/s1678-9946202062066 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
62 |
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1809897406320345088 |