Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children
Abstract Background The haemolysis associated with clinical episodes of malaria results in the liberation of haem, which activates the enzyme haem oxygenase-1 (HO-1). HO-1 has been shown to reduce neutrophil function and increase susceptibility to invasive bacterial disease. However, the majority of...
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ftdoajarticles:oai:doaj.org/article:a63115c124924598ba28861f02b68184 2023-05-15T15:10:29+02:00 Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children Jason P. Mooney Aissata Barry Bronner P. Gonçalves Alfred B. Tiono Shehu S. Awandu Lynn Grignard Chris J. Drakeley Christian Bottomley Teun Bousema Eleanor M. Riley 2018-07-01T00:00:00Z https://doi.org/10.1186/s12936-018-2402-6 https://doaj.org/article/a63115c124924598ba28861f02b68184 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2402-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2402-6 1475-2875 https://doaj.org/article/a63115c124924598ba28861f02b68184 Malaria Journal, Vol 17, Iss 1, Pp 1-11 (2018) Subclinical malaria Anaemia Haemolysis IL-10 HO-1 Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2402-6 2022-12-31T05:34:41Z Abstract Background The haemolysis associated with clinical episodes of malaria results in the liberation of haem, which activates the enzyme haem oxygenase-1 (HO-1). HO-1 has been shown to reduce neutrophil function and increase susceptibility to invasive bacterial disease. However, the majority of community-associated malaria infections are subclinical, often termed “asymptomatic” and the consequences of low-grade haemolysis during subclinical malaria infection are unknown. Study design and results As part of an ongoing study of subclinical malaria in Burkina Faso, 23 children with subclinical Plasmodium falciparum infections (determined by qPCR) were compared with 21 village-matched uninfected control children. Infected children showed evidence of persistent haemolysis over 35 days, with raised plasma haem and HO-1 concentrations. Concentrations of IL-10, which can also directly activate HO-1, were also higher in infected children compared to uninfected children. Regression analysis revealed that HO-1 was associated with haemolysis, but not with parasite density, anaemia or IL-10 concentration. Conclusions This study reveals that subclinical P. falciparum malaria infection is associated with sustained haemolysis and the induction of HO-1. Given the association between HO-1, neutrophil dysfunction and increased risk of Salmonella bacteraemia, prolonged HO-1 induction may explain epidemiological associations and geographic overlap between malaria and invasive bacterial disease. Further studies are needed to understand the consequences of persistent subclinical malaria infection, low-grade haemolysis and raised HO-1 on immune cell function and risk of comorbidities. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Subclinical malaria Anaemia Haemolysis IL-10 HO-1 Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Subclinical malaria Anaemia Haemolysis IL-10 HO-1 Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Jason P. Mooney Aissata Barry Bronner P. Gonçalves Alfred B. Tiono Shehu S. Awandu Lynn Grignard Chris J. Drakeley Christian Bottomley Teun Bousema Eleanor M. Riley Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children |
topic_facet |
Subclinical malaria Anaemia Haemolysis IL-10 HO-1 Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The haemolysis associated with clinical episodes of malaria results in the liberation of haem, which activates the enzyme haem oxygenase-1 (HO-1). HO-1 has been shown to reduce neutrophil function and increase susceptibility to invasive bacterial disease. However, the majority of community-associated malaria infections are subclinical, often termed “asymptomatic” and the consequences of low-grade haemolysis during subclinical malaria infection are unknown. Study design and results As part of an ongoing study of subclinical malaria in Burkina Faso, 23 children with subclinical Plasmodium falciparum infections (determined by qPCR) were compared with 21 village-matched uninfected control children. Infected children showed evidence of persistent haemolysis over 35 days, with raised plasma haem and HO-1 concentrations. Concentrations of IL-10, which can also directly activate HO-1, were also higher in infected children compared to uninfected children. Regression analysis revealed that HO-1 was associated with haemolysis, but not with parasite density, anaemia or IL-10 concentration. Conclusions This study reveals that subclinical P. falciparum malaria infection is associated with sustained haemolysis and the induction of HO-1. Given the association between HO-1, neutrophil dysfunction and increased risk of Salmonella bacteraemia, prolonged HO-1 induction may explain epidemiological associations and geographic overlap between malaria and invasive bacterial disease. Further studies are needed to understand the consequences of persistent subclinical malaria infection, low-grade haemolysis and raised HO-1 on immune cell function and risk of comorbidities. |
format |
Article in Journal/Newspaper |
author |
Jason P. Mooney Aissata Barry Bronner P. Gonçalves Alfred B. Tiono Shehu S. Awandu Lynn Grignard Chris J. Drakeley Christian Bottomley Teun Bousema Eleanor M. Riley |
author_facet |
Jason P. Mooney Aissata Barry Bronner P. Gonçalves Alfred B. Tiono Shehu S. Awandu Lynn Grignard Chris J. Drakeley Christian Bottomley Teun Bousema Eleanor M. Riley |
author_sort |
Jason P. Mooney |
title |
Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children |
title_short |
Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children |
title_full |
Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children |
title_fullStr |
Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children |
title_full_unstemmed |
Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children |
title_sort |
haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in burkinabé children |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2402-6 https://doaj.org/article/a63115c124924598ba28861f02b68184 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-11 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2402-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2402-6 1475-2875 https://doaj.org/article/a63115c124924598ba28861f02b68184 |
op_doi |
https://doi.org/10.1186/s12936-018-2402-6 |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766341510989611008 |