Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats
Objective: To evaluate the antidiabetic and antihyperlipidaemic effect of ethanol extract of Melastoma malabathricum (M. malabathricum) Linn. leaf in alloxan induced diabetic rats. Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). the ethanol extr...
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Wolters Kluwer Medknow Publications
2014
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Online Access: | https://doi.org/10.12980/APJTB.4.2014C122 https://doaj.org/article/a620999a75ba4a92a31774141e16b5e4 |
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ftdoajarticles:oai:doaj.org/article:a620999a75ba4a92a31774141e16b5e4 2023-05-15T15:11:04+02:00 Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats Karuppasamy Balamurugan Antony Nishanthini Veerabahu Ramasamy Mohan 2014-05-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014C122 https://doaj.org/article/a620999a75ba4a92a31774141e16b5e4 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115303087 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C122 https://doaj.org/article/a620999a75ba4a92a31774141e16b5e4 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S442-S448 (2014) Melastoma malabathricum Antidiabetic Antihyperlipidaemic Alloxan Glibenclamide SGOT SGPT HbA1c Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014C122 2022-12-31T15:00:39Z Objective: To evaluate the antidiabetic and antihyperlipidaemic effect of ethanol extract of Melastoma malabathricum (M. malabathricum) Linn. leaf in alloxan induced diabetic rats. Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). the ethanol extracts of M. malabathricum at a dose of 150 and 300 mg/kg of body weight were administrated at a single dose per day to diabetes induced rats for a period of 14 d. The effect of ethanol extract of M. malabathricum leaf extract on blood glucose, plasma insulin, creatinine, glycosylated haemoglobin, urea serum lipid profile [total cholesterol, triglycerides, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and phospholipid, serum protein, albumin, globulin, serum enzymes (serum glutamate pyruvate transaminases), serum glutamate oxaloacetate transaminases, and alkaline phosphatase] were measured in the diabetic rats. Results: In the acute toxicity study, ethanol extract of M. malabathricum leaf was non-toxic at 2 000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of M. malabathricum leaf compared to diabetic control rats. In diabetic rats, ethanol extract of M. malabathricum leaf administration, altered lipid profiles were reversed to near normal than diabetic control rats. Conclusions: Ethanol extract of M. malabathricum leaf possesses significant antidiabetic and antihyperlipidaemic activity in diabetic rats. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 S442 S448 |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Melastoma malabathricum Antidiabetic Antihyperlipidaemic Alloxan Glibenclamide SGOT SGPT HbA1c Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Melastoma malabathricum Antidiabetic Antihyperlipidaemic Alloxan Glibenclamide SGOT SGPT HbA1c Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Karuppasamy Balamurugan Antony Nishanthini Veerabahu Ramasamy Mohan Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats |
topic_facet |
Melastoma malabathricum Antidiabetic Antihyperlipidaemic Alloxan Glibenclamide SGOT SGPT HbA1c Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the antidiabetic and antihyperlipidaemic effect of ethanol extract of Melastoma malabathricum (M. malabathricum) Linn. leaf in alloxan induced diabetic rats. Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). the ethanol extracts of M. malabathricum at a dose of 150 and 300 mg/kg of body weight were administrated at a single dose per day to diabetes induced rats for a period of 14 d. The effect of ethanol extract of M. malabathricum leaf extract on blood glucose, plasma insulin, creatinine, glycosylated haemoglobin, urea serum lipid profile [total cholesterol, triglycerides, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and phospholipid, serum protein, albumin, globulin, serum enzymes (serum glutamate pyruvate transaminases), serum glutamate oxaloacetate transaminases, and alkaline phosphatase] were measured in the diabetic rats. Results: In the acute toxicity study, ethanol extract of M. malabathricum leaf was non-toxic at 2 000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of M. malabathricum leaf compared to diabetic control rats. In diabetic rats, ethanol extract of M. malabathricum leaf administration, altered lipid profiles were reversed to near normal than diabetic control rats. Conclusions: Ethanol extract of M. malabathricum leaf possesses significant antidiabetic and antihyperlipidaemic activity in diabetic rats. |
format |
Article in Journal/Newspaper |
author |
Karuppasamy Balamurugan Antony Nishanthini Veerabahu Ramasamy Mohan |
author_facet |
Karuppasamy Balamurugan Antony Nishanthini Veerabahu Ramasamy Mohan |
author_sort |
Karuppasamy Balamurugan |
title |
Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats |
title_short |
Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats |
title_full |
Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats |
title_fullStr |
Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats |
title_full_unstemmed |
Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats |
title_sort |
antidiabetic and antihyperlipidaemic activity of ethanol extract of melastoma malabathricum linn. leaf in alloxan induced diabetic rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014C122 https://doaj.org/article/a620999a75ba4a92a31774141e16b5e4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S442-S448 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115303087 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C122 https://doaj.org/article/a620999a75ba4a92a31774141e16b5e4 |
op_doi |
https://doi.org/10.12980/APJTB.4.2014C122 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_start_page |
S442 |
op_container_end_page |
S448 |
_version_ |
1766341979337129984 |