How antimalarial drug resistance affects post-treatment prophylaxis
Abstract Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis (PTP). The clinical benefits of pre...
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ftdoajarticles:oai:doaj.org/article:a614f15c537b4372999da30982321ce8 2023-05-15T15:01:41+02:00 How antimalarial drug resistance affects post-treatment prophylaxis White Nicholas J 2008-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-9 https://doaj.org/article/a614f15c537b4372999da30982321ce8 EN eng BMC http://www.malariajournal.com/content/7/1/9 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-9 1475-2875 https://doaj.org/article/a614f15c537b4372999da30982321ce8 Malaria Journal, Vol 7, Iss 1, p 9 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-9 2022-12-31T11:46:37Z Abstract Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis (PTP). The clinical benefits of preventing recrudescence (reflecting treatment efficacy) compared with preventing reinfection (reflecting PTP) need further assessment. Antimalarial drug resistance shortens PTP. While blood concentrations are in the terminal elimination phase, the degree of shortening may be estimated from measurements of in-vitro susceptibility and the terminal elimination half-life. More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 White Nicholas J How antimalarial drug resistance affects post-treatment prophylaxis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis (PTP). The clinical benefits of preventing recrudescence (reflecting treatment efficacy) compared with preventing reinfection (reflecting PTP) need further assessment. Antimalarial drug resistance shortens PTP. While blood concentrations are in the terminal elimination phase, the degree of shortening may be estimated from measurements of in-vitro susceptibility and the terminal elimination half-life. More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base. |
format |
Article in Journal/Newspaper |
author |
White Nicholas J |
author_facet |
White Nicholas J |
author_sort |
White Nicholas J |
title |
How antimalarial drug resistance affects post-treatment prophylaxis |
title_short |
How antimalarial drug resistance affects post-treatment prophylaxis |
title_full |
How antimalarial drug resistance affects post-treatment prophylaxis |
title_fullStr |
How antimalarial drug resistance affects post-treatment prophylaxis |
title_full_unstemmed |
How antimalarial drug resistance affects post-treatment prophylaxis |
title_sort |
how antimalarial drug resistance affects post-treatment prophylaxis |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-9 https://doaj.org/article/a614f15c537b4372999da30982321ce8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 9 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/9 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-9 1475-2875 https://doaj.org/article/a614f15c537b4372999da30982321ce8 |
op_doi |
https://doi.org/10.1186/1475-2875-7-9 |
container_title |
Malaria Journal |
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7 |
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1 |
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1766333686664396800 |