Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits
The Scandinavian region is home to a unique biome with endemic plant species. The aim of this study was to explore this natural diversity and identify plant extracts providing positive skin barrier effects. Six plant extracts were identified as starting material. Following biochemical screening, two...
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ftdoajarticles:oai:doaj.org/article:a5c4f44515c1443d94c4fd207db9b205 2023-05-15T16:06:03+02:00 Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits Sandra Smiljanic Cyril Messaraa Virginie Lafon-Kolb Nina Hrapovic Nahid Amini Christina Osterlund Lene Visdal-Johnsen 2022-10-01T00:00:00Z https://doi.org/10.3390/ijms232012507 https://doaj.org/article/a5c4f44515c1443d94c4fd207db9b205 EN eng MDPI AG https://www.mdpi.com/1422-0067/23/20/12507 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms232012507 1422-0067 1661-6596 https://doaj.org/article/a5c4f44515c1443d94c4fd207db9b205 International Journal of Molecular Sciences, Vol 23, Iss 12507, p 12507 (2022) skin barrier hydration Scandinavian endemic plants natural ingredient Betula alba Empetrum nigrum Biology (General) QH301-705.5 Chemistry QD1-999 article 2022 ftdoajarticles https://doi.org/10.3390/ijms232012507 2022-12-30T20:28:58Z The Scandinavian region is home to a unique biome with endemic plant species. The aim of this study was to explore this natural diversity and identify plant extracts providing positive skin barrier effects. Six plant extracts were identified as starting material. Following biochemical screening, two candidates outperformed the rest: Betula alba (BA) and Empetrum nigrum (EN). Quantitative PCR analysis showed that BA and EN upregulated barrier genes, when used individually and in combination. Betula alba increased AQP3 and OCLN protein expression, something niacinamide was incapable of. Additionally, the skin barrier was strengthened, evidenced by inhibition of KLK5 and hyaluronidase and showed strong antioxidant and anti-inflammatory activity through DPPH and COX2 inhibition, respectively. A first split-face clinical study was conducted using the combination of extracts versus placebo. There was a significantly better skin restructuring effect and corneocyte cohesion on the side treated with combined extracts. A second split-face clinical study assessed the combined extracts versus 3% niacinamide. Significant variations in skin hydration and TEWL were observed in favor of the extract treated side. In conclusion, we identified a natural alternative to niacinamide for improving skin barrier health, in Scandinavian plant extracts, which yield strong performance, but at a lower concentration. Article in Journal/Newspaper Empetrum nigrum Directory of Open Access Journals: DOAJ Articles International Journal of Molecular Sciences 23 20 12507 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
skin barrier hydration Scandinavian endemic plants natural ingredient Betula alba Empetrum nigrum Biology (General) QH301-705.5 Chemistry QD1-999 |
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skin barrier hydration Scandinavian endemic plants natural ingredient Betula alba Empetrum nigrum Biology (General) QH301-705.5 Chemistry QD1-999 Sandra Smiljanic Cyril Messaraa Virginie Lafon-Kolb Nina Hrapovic Nahid Amini Christina Osterlund Lene Visdal-Johnsen Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits |
topic_facet |
skin barrier hydration Scandinavian endemic plants natural ingredient Betula alba Empetrum nigrum Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
The Scandinavian region is home to a unique biome with endemic plant species. The aim of this study was to explore this natural diversity and identify plant extracts providing positive skin barrier effects. Six plant extracts were identified as starting material. Following biochemical screening, two candidates outperformed the rest: Betula alba (BA) and Empetrum nigrum (EN). Quantitative PCR analysis showed that BA and EN upregulated barrier genes, when used individually and in combination. Betula alba increased AQP3 and OCLN protein expression, something niacinamide was incapable of. Additionally, the skin barrier was strengthened, evidenced by inhibition of KLK5 and hyaluronidase and showed strong antioxidant and anti-inflammatory activity through DPPH and COX2 inhibition, respectively. A first split-face clinical study was conducted using the combination of extracts versus placebo. There was a significantly better skin restructuring effect and corneocyte cohesion on the side treated with combined extracts. A second split-face clinical study assessed the combined extracts versus 3% niacinamide. Significant variations in skin hydration and TEWL were observed in favor of the extract treated side. In conclusion, we identified a natural alternative to niacinamide for improving skin barrier health, in Scandinavian plant extracts, which yield strong performance, but at a lower concentration. |
format |
Article in Journal/Newspaper |
author |
Sandra Smiljanic Cyril Messaraa Virginie Lafon-Kolb Nina Hrapovic Nahid Amini Christina Osterlund Lene Visdal-Johnsen |
author_facet |
Sandra Smiljanic Cyril Messaraa Virginie Lafon-Kolb Nina Hrapovic Nahid Amini Christina Osterlund Lene Visdal-Johnsen |
author_sort |
Sandra Smiljanic |
title |
Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits |
title_short |
Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits |
title_full |
Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits |
title_fullStr |
Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits |
title_full_unstemmed |
Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits |
title_sort |
betula alba bark extract and empetrum nigrum fruit juice, a natural alternative to niacinamide for skin barrier benefits |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijms232012507 https://doaj.org/article/a5c4f44515c1443d94c4fd207db9b205 |
genre |
Empetrum nigrum |
genre_facet |
Empetrum nigrum |
op_source |
International Journal of Molecular Sciences, Vol 23, Iss 12507, p 12507 (2022) |
op_relation |
https://www.mdpi.com/1422-0067/23/20/12507 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms232012507 1422-0067 1661-6596 https://doaj.org/article/a5c4f44515c1443d94c4fd207db9b205 |
op_doi |
https://doi.org/10.3390/ijms232012507 |
container_title |
International Journal of Molecular Sciences |
container_volume |
23 |
container_issue |
20 |
container_start_page |
12507 |
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1766401967430565888 |