Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis
ABSTRACT Trypanosoma cruzi is the causative agent of Chagas disease. Nowadays, the transmission in Brazil occurs mainly by oral ingestion of contaminated food that has been associated with more severe clinical manifestations. We report a case of Acute Chagas disease caused by oral transmission in a...
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ftdoajarticles:oai:doaj.org/article:a5bc1830112e4ca28adc3f2011d69d30 2024-09-09T19:25:36+00:00 Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis Helena Rangel Esper Vera Lucia Teixeira de Freitas João Guilherme Pontes Lima Assy Erika Yoshie Shimoda Olivia Campos Pinheiro Berreta Marta Heloisa Lopes Francisco Oscar Siqueira França 2019-05-01T00:00:00Z https://doi.org/10.1590/s1678-9946201961027 https://doaj.org/article/a5bc1830112e4ca28adc3f2011d69d30 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000503&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201961027 https://doaj.org/article/a5bc1830112e4ca28adc3f2011d69d30 Revista do Instituto de Medicina Tropical de São Paulo, Vol 61, Iss 0 (2019) Acute Chagas disease Trypanosoma cruzi qPCR Bacaba palm fruit Children Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1590/s1678-9946201961027 2024-08-05T17:49:30Z ABSTRACT Trypanosoma cruzi is the causative agent of Chagas disease. Nowadays, the transmission in Brazil occurs mainly by oral ingestion of contaminated food that has been associated with more severe clinical manifestations. We report a case of Acute Chagas disease caused by oral transmission in a child from Northern Brazil. In the hospital admission, physical examination showed tachycardia, hepatomegaly, bipalpebral edema and anasarca. Trypanosoma cruzi trypomastigotes were found in microscopy during blood cell count. Twenty-three days before hospitalization, the child had ingested the “bacaba palm fruit's wine”. Even with the appropriate diagnosis and starting of treatment, she did not survive. Quantitative analysis of Trypanosoma cruzi DNA in a blood sample resulted in 54,053.42 parasite equivalents/mL and the DTU TcIV was identified. The outcome may have been determined by several factors, including the delay to seek a medical service beyond the high parasitemia, detected by qPCR. DTU TcIV could also have influenced the natural history of the disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 61 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Acute Chagas disease Trypanosoma cruzi qPCR Bacaba palm fruit Children Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Acute Chagas disease Trypanosoma cruzi qPCR Bacaba palm fruit Children Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Helena Rangel Esper Vera Lucia Teixeira de Freitas João Guilherme Pontes Lima Assy Erika Yoshie Shimoda Olivia Campos Pinheiro Berreta Marta Heloisa Lopes Francisco Oscar Siqueira França Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis |
topic_facet |
Acute Chagas disease Trypanosoma cruzi qPCR Bacaba palm fruit Children Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Trypanosoma cruzi is the causative agent of Chagas disease. Nowadays, the transmission in Brazil occurs mainly by oral ingestion of contaminated food that has been associated with more severe clinical manifestations. We report a case of Acute Chagas disease caused by oral transmission in a child from Northern Brazil. In the hospital admission, physical examination showed tachycardia, hepatomegaly, bipalpebral edema and anasarca. Trypanosoma cruzi trypomastigotes were found in microscopy during blood cell count. Twenty-three days before hospitalization, the child had ingested the “bacaba palm fruit's wine”. Even with the appropriate diagnosis and starting of treatment, she did not survive. Quantitative analysis of Trypanosoma cruzi DNA in a blood sample resulted in 54,053.42 parasite equivalents/mL and the DTU TcIV was identified. The outcome may have been determined by several factors, including the delay to seek a medical service beyond the high parasitemia, detected by qPCR. DTU TcIV could also have influenced the natural history of the disease. |
format |
Article in Journal/Newspaper |
author |
Helena Rangel Esper Vera Lucia Teixeira de Freitas João Guilherme Pontes Lima Assy Erika Yoshie Shimoda Olivia Campos Pinheiro Berreta Marta Heloisa Lopes Francisco Oscar Siqueira França |
author_facet |
Helena Rangel Esper Vera Lucia Teixeira de Freitas João Guilherme Pontes Lima Assy Erika Yoshie Shimoda Olivia Campos Pinheiro Berreta Marta Heloisa Lopes Francisco Oscar Siqueira França |
author_sort |
Helena Rangel Esper |
title |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis |
title_short |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis |
title_full |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis |
title_fullStr |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis |
title_full_unstemmed |
Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis |
title_sort |
fatal evolution of acute chagas disease in a child from northern brazil: factors that determine poor prognosis |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2019 |
url |
https://doi.org/10.1590/s1678-9946201961027 https://doaj.org/article/a5bc1830112e4ca28adc3f2011d69d30 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 61, Iss 0 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000503&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201961027 https://doaj.org/article/a5bc1830112e4ca28adc3f2011d69d30 |
op_doi |
https://doi.org/10.1590/s1678-9946201961027 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
61 |
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