Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study
The Arctic populations have high blood concentrations of persistent organic pollutants (POPs). Exposure to POPs was related to adverse health effects e.g. immune, neurological and reproductive systems. This study investigates associations between serum POP levels and haematological markers in Greenl...
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ftdoajarticles:oai:doaj.org/article:a5925b251ed44ac293da5227c9916e82 2023-05-15T14:57:40+02:00 Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study Ane-Kersti Skaarup Knudsen Manhai Long Henning Sloth Pedersen Eva Cecilie Bonefeld-Jørgensen 2018-01-01T00:00:00Z https://doi.org/10.1080/22423982.2018.1456303 https://doaj.org/article/a5925b251ed44ac293da5227c9916e82 EN eng Taylor & Francis Group http://dx.doi.org/10.1080/22423982.2018.1456303 https://doaj.org/toc/2242-3982 2242-3982 doi:10.1080/22423982.2018.1456303 https://doaj.org/article/a5925b251ed44ac293da5227c9916e82 International Journal of Circumpolar Health, Vol 77, Iss 1 (2018) Persistent organic pollutants blood samples haematological markers Inuit pregnancy Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.1080/22423982.2018.1456303 2022-12-31T04:40:56Z The Arctic populations have high blood concentrations of persistent organic pollutants (POPs). Exposure to POPs was related to adverse health effects e.g. immune, neurological and reproductive systems. This study investigates associations between serum POP levels and haematological markers in Greenlandic pregnant women. This cross-sectional study included 189 women enrolled in 2010–2011 at the Greenlandic West coast by the inclusion criteria ≥18 years of age and had lived for 50% or more of their life in Greenland. The associations between the sum of the POP variables polychlorinated biphenyls (sumPCBs), organochlorine pesticides (sumOCPs), perfluoroalkylated substances (sumPFASs) and 24 haematological markers were analysed using linear regression adjusted for age, pre-pregnancy BMI, parity, gestation week, plasma-cotinine and alcohol intake. It showed a significantly inverse association between several haematological markers (eosinophil, lymphocyte, neutrophil and white blood cells) and sumPCBs, sumOCPs and sumPFASs. In addition, the monocyte, mean corpuscular haemoglobin concentration, plateletcrit and platelet count markers were significantly inversely associated with sumPFASs, but the haematocrit and mean erythrocyte corpuscular volume were positively associated with sumPFASs. In conclusion, exposure to POPs influenced several haematological markers, especially cell count parameters, suggesting immunosuppressive potential of POPs in Greenlandic pregnant women. The data need further investigations. Article in Journal/Newspaper Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health inuit Directory of Open Access Journals: DOAJ Articles Arctic Greenland International Journal of Circumpolar Health 77 1 1456303 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Persistent organic pollutants blood samples haematological markers Inuit pregnancy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Persistent organic pollutants blood samples haematological markers Inuit pregnancy Arctic medicine. Tropical medicine RC955-962 Ane-Kersti Skaarup Knudsen Manhai Long Henning Sloth Pedersen Eva Cecilie Bonefeld-Jørgensen Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study |
topic_facet |
Persistent organic pollutants blood samples haematological markers Inuit pregnancy Arctic medicine. Tropical medicine RC955-962 |
description |
The Arctic populations have high blood concentrations of persistent organic pollutants (POPs). Exposure to POPs was related to adverse health effects e.g. immune, neurological and reproductive systems. This study investigates associations between serum POP levels and haematological markers in Greenlandic pregnant women. This cross-sectional study included 189 women enrolled in 2010–2011 at the Greenlandic West coast by the inclusion criteria ≥18 years of age and had lived for 50% or more of their life in Greenland. The associations between the sum of the POP variables polychlorinated biphenyls (sumPCBs), organochlorine pesticides (sumOCPs), perfluoroalkylated substances (sumPFASs) and 24 haematological markers were analysed using linear regression adjusted for age, pre-pregnancy BMI, parity, gestation week, plasma-cotinine and alcohol intake. It showed a significantly inverse association between several haematological markers (eosinophil, lymphocyte, neutrophil and white blood cells) and sumPCBs, sumOCPs and sumPFASs. In addition, the monocyte, mean corpuscular haemoglobin concentration, plateletcrit and platelet count markers were significantly inversely associated with sumPFASs, but the haematocrit and mean erythrocyte corpuscular volume were positively associated with sumPFASs. In conclusion, exposure to POPs influenced several haematological markers, especially cell count parameters, suggesting immunosuppressive potential of POPs in Greenlandic pregnant women. The data need further investigations. |
format |
Article in Journal/Newspaper |
author |
Ane-Kersti Skaarup Knudsen Manhai Long Henning Sloth Pedersen Eva Cecilie Bonefeld-Jørgensen |
author_facet |
Ane-Kersti Skaarup Knudsen Manhai Long Henning Sloth Pedersen Eva Cecilie Bonefeld-Jørgensen |
author_sort |
Ane-Kersti Skaarup Knudsen |
title |
Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study |
title_short |
Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study |
title_full |
Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study |
title_fullStr |
Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study |
title_full_unstemmed |
Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study |
title_sort |
persistent organic pollutants and haematological markers in greenlandic pregnant women: the accept sub-study |
publisher |
Taylor & Francis Group |
publishDate |
2018 |
url |
https://doi.org/10.1080/22423982.2018.1456303 https://doaj.org/article/a5925b251ed44ac293da5227c9916e82 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Circumpolar Health Greenland greenlandic International Journal of Circumpolar Health inuit |
op_source |
International Journal of Circumpolar Health, Vol 77, Iss 1 (2018) |
op_relation |
http://dx.doi.org/10.1080/22423982.2018.1456303 https://doaj.org/toc/2242-3982 2242-3982 doi:10.1080/22423982.2018.1456303 https://doaj.org/article/a5925b251ed44ac293da5227c9916e82 |
op_doi |
https://doi.org/10.1080/22423982.2018.1456303 |
container_title |
International Journal of Circumpolar Health |
container_volume |
77 |
container_issue |
1 |
container_start_page |
1456303 |
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1766329793962311680 |