Helminth colonization is associated with increased diversity of the gut microbiota.
Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut microbiota. Differences in the gut microbiota between individuals living in developed and developing countries may be partly due to the presen...
Published in: | PLoS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0002880 https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac |
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ftdoajarticles:oai:doaj.org/article:a5505b5b0aa240f894d65ab86d6a07ac 2023-05-15T15:06:43+02:00 Helminth colonization is associated with increased diversity of the gut microbiota. Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke 2014-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002880 https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24851867/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002880 https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2880 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002880 2022-12-31T16:22:12Z Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut microbiota. Differences in the gut microbiota between individuals living in developed and developing countries may be partly due to the presence of helminths, since they predominantly infect individuals from developing countries, such as the indigenous communities in Malaysia we examine in this work. We compared the composition and diversity of bacterial communities from the fecal microbiota of 51 people from two villages in Malaysia, of which 36 (70.6%) were infected by helminths. The 16S rRNA V4 region was sequenced at an average of nineteen thousand sequences per samples. Helminth-colonized individuals had greater species richness and number of observed OTUs with enrichment of Paraprevotellaceae, especially with Trichuris infection. We developed a new approach of combining centered log-ratio (clr) transformation for OTU relative abundances with sparse Partial Least Squares Discriminant Analysis (sPLS-DA) to enable more robust predictions of OTU interrelationships. These results suggest that helminths may have an impact on the diversity, bacterial community structure and function of the gut microbiota. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 5 e2880 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke Helminth colonization is associated with increased diversity of the gut microbiota. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut microbiota. Differences in the gut microbiota between individuals living in developed and developing countries may be partly due to the presence of helminths, since they predominantly infect individuals from developing countries, such as the indigenous communities in Malaysia we examine in this work. We compared the composition and diversity of bacterial communities from the fecal microbiota of 51 people from two villages in Malaysia, of which 36 (70.6%) were infected by helminths. The 16S rRNA V4 region was sequenced at an average of nineteen thousand sequences per samples. Helminth-colonized individuals had greater species richness and number of observed OTUs with enrichment of Paraprevotellaceae, especially with Trichuris infection. We developed a new approach of combining centered log-ratio (clr) transformation for OTU relative abundances with sparse Partial Least Squares Discriminant Analysis (sPLS-DA) to enable more robust predictions of OTU interrelationships. These results suggest that helminths may have an impact on the diversity, bacterial community structure and function of the gut microbiota. |
format |
Article in Journal/Newspaper |
author |
Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke |
author_facet |
Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke |
author_sort |
Soo Ching Lee |
title |
Helminth colonization is associated with increased diversity of the gut microbiota. |
title_short |
Helminth colonization is associated with increased diversity of the gut microbiota. |
title_full |
Helminth colonization is associated with increased diversity of the gut microbiota. |
title_fullStr |
Helminth colonization is associated with increased diversity of the gut microbiota. |
title_full_unstemmed |
Helminth colonization is associated with increased diversity of the gut microbiota. |
title_sort |
helminth colonization is associated with increased diversity of the gut microbiota. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002880 https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2880 (2014) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24851867/pdf/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002880 https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac |
op_doi |
https://doi.org/10.1371/journal.pntd.0002880 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
5 |
container_start_page |
e2880 |
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1766338276953686016 |