Genetic insights and evaluation of forensic features in Mongolian and Ewenki groups using the InDel variations

Background: InDel polymorphisms show great potential for use with challenging DNA samples in forensic practice due to having similar advantages to STRs and SNPs. Large-scale InDel genotype data are becoming available world wide populations, thus providing an alternative for investigating genetic arc...

Full description

Bibliographic Details
Published in:Frontiers in Bioscience-Landmark
Main Authors: Qiong Lan, Congying Zhao, Cong Wei, Hui Xu, Chunmei Shen, Bofeng Zhu
Format: Article in Journal/Newspaper
Language:English
Published: IMR Press 2022
Subjects:
indel
mongolian
ewenki
forensic efficiency
genetic structure
Biochemistry
QD415-436
Biology (General)
QH301-705.5
Indel’
Ewenki
Online Access:https://doi.org/10.31083/j.fbl2702067
https://doaj.org/article/a52a44d67ea04711b610379113698f5c
Description
Summary:Background: InDel polymorphisms show great potential for use with challenging DNA samples in forensic practice due to having similar advantages to STRs and SNPs. Large-scale InDel genotype data are becoming available world wide populations, thus providing an alternative for investigating genetic architectures in rarely studied populations from a genome perspective. Methods: Here, we genotyped 47 highly polymorphic InDel variations in 157 Mongolian and 100 Ewenki individuals from the Inner Mongolia Autonomous Region of China in order to evaluate their utility for forensic purposes. Results: The CDPs of the 47 InDels for these groups were calculated to be 0.999999999999999999874 and 0.999999999999999999677, respectively, while the CPEs were 0.99981 and 0.99975, respectively. The 47 InDel variations were therefore an efficient tool for forensic personal identification in the Mongolian and Ewenki ethnic groups. Comparison of results from the present study with datasets from previously published literatures and from the 1000 Genomes Project revealed a prominent East Asian ancestry component in the gene pool of both ethnic groups, hinting at the close genetic relationships between Mongolian, Ewenki and most East Asian populations. Furthermore, Han populations from northern China showed even closer genetic affinities with the Mongolian and Ewenki groups. Conclusions: The data presented here would facilitate the forensic application of InDels for Mongolian and Ewenki ethnic minorities and expand our knowledge regarding the genetic diversities of these populations.

Similar Items