Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review
Abstract Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas dis...
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ftdoajarticles:oai:doaj.org/article:a50569e1dc244ffb9f3107c7b8f5e53c 2023-05-15T15:09:05+02:00 Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review Cauê Benito Scarim Aline Rimoldi Ribeiro João Aristeu da Rosa Chung Man Chin https://doi.org/10.1590/0037-8682-0337-2017 https://doaj.org/article/a50569e1dc244ffb9f3107c7b8f5e53c EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000200133&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0337-2017 https://doaj.org/article/a50569e1dc244ffb9f3107c7b8f5e53c Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 2, Pp 133-140 Benznidazole Chagas disease Chronic phase Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0337-2017 2022-12-31T03:21:34Z Abstract Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective, existing, experimental chronic protocols that can be used for comparison purposes. Here, we present a literature review regarding experimental models with chronic Chagas disease to evaluate the efficacy of benznidazole (BZN). We searched literature published in PubMed and Web of Science databases, using these keywords: animal model, BZN, Chagas disease, T. cruzi, and chronic phase, with no timeframe limitations. We excluded articles involving acute phase animal models and/or those without BZN treatment. The selected studies were conducted using different BZN concentrations (10mg-100mg) involving several different periods (5-70 days). Concentrations and durations of use are directly related to side effects, but do not prevent chronic tissue lesions. BZN use during the late/chronic phases of Chagas disease is unable to eliminate amastigote forms present in infected tissues. This study suggests the administration of a lower BZN concentration (<100mg/kg/day) during the chronic phase of the animal model, as this had been reported to result in fewer side effects. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 51 2 133 140 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Benznidazole Chagas disease Chronic phase Arctic medicine. Tropical medicine RC955-962 |
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Benznidazole Chagas disease Chronic phase Arctic medicine. Tropical medicine RC955-962 Cauê Benito Scarim Aline Rimoldi Ribeiro João Aristeu da Rosa Chung Man Chin Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review |
topic_facet |
Benznidazole Chagas disease Chronic phase Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective, existing, experimental chronic protocols that can be used for comparison purposes. Here, we present a literature review regarding experimental models with chronic Chagas disease to evaluate the efficacy of benznidazole (BZN). We searched literature published in PubMed and Web of Science databases, using these keywords: animal model, BZN, Chagas disease, T. cruzi, and chronic phase, with no timeframe limitations. We excluded articles involving acute phase animal models and/or those without BZN treatment. The selected studies were conducted using different BZN concentrations (10mg-100mg) involving several different periods (5-70 days). Concentrations and durations of use are directly related to side effects, but do not prevent chronic tissue lesions. BZN use during the late/chronic phases of Chagas disease is unable to eliminate amastigote forms present in infected tissues. This study suggests the administration of a lower BZN concentration (<100mg/kg/day) during the chronic phase of the animal model, as this had been reported to result in fewer side effects. |
format |
Article in Journal/Newspaper |
author |
Cauê Benito Scarim Aline Rimoldi Ribeiro João Aristeu da Rosa Chung Man Chin |
author_facet |
Cauê Benito Scarim Aline Rimoldi Ribeiro João Aristeu da Rosa Chung Man Chin |
author_sort |
Cauê Benito Scarim |
title |
Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review |
title_short |
Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review |
title_full |
Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review |
title_fullStr |
Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review |
title_full_unstemmed |
Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review |
title_sort |
response to different benznidazole doses in animal models of chronic phase chagas disease: a critical review |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0337-2017 https://doaj.org/article/a50569e1dc244ffb9f3107c7b8f5e53c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 2, Pp 133-140 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000200133&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0337-2017 https://doaj.org/article/a50569e1dc244ffb9f3107c7b8f5e53c |
op_doi |
https://doi.org/10.1590/0037-8682-0337-2017 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
51 |
container_issue |
2 |
container_start_page |
133 |
op_container_end_page |
140 |
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