Cytokine and antibody production during murine leptospirosis
The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising...
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ftdoajarticles:oai:doaj.org/article:a4b8378ec734478ab44b6b2ae202004b 2023-05-15T15:07:08+02:00 Cytokine and antibody production during murine leptospirosis M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000400006 https://doaj.org/article/a4b8378ec734478ab44b6b2ae202004b EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000400006 1678-9199 https://doaj.org/article/a4b8378ec734478ab44b6b2ae202004b Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 4, Pp 595-603 (2006) cytokines cellular immune response BALB/c mice leptospirosis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000400006 2022-12-31T15:05:08Z The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-alpha and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-alpha and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-alpha and IL-6 could be associated with the immunopathogenesis of the disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 4 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cytokines cellular immune response BALB/c mice leptospirosis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
cytokines cellular immune response BALB/c mice leptospirosis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri Cytokine and antibody production during murine leptospirosis |
topic_facet |
cytokines cellular immune response BALB/c mice leptospirosis Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-alpha and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-alpha and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-alpha and IL-6 could be associated with the immunopathogenesis of the disease. |
format |
Article in Journal/Newspaper |
author |
M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri |
author_facet |
M. Marinho C. Silva V. M. F. Lima J. R. Peiró S. H. V. Perri |
author_sort |
M. Marinho |
title |
Cytokine and antibody production during murine leptospirosis |
title_short |
Cytokine and antibody production during murine leptospirosis |
title_full |
Cytokine and antibody production during murine leptospirosis |
title_fullStr |
Cytokine and antibody production during murine leptospirosis |
title_full_unstemmed |
Cytokine and antibody production during murine leptospirosis |
title_sort |
cytokine and antibody production during murine leptospirosis |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000400006 https://doaj.org/article/a4b8378ec734478ab44b6b2ae202004b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 4, Pp 595-603 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000400006 1678-9199 https://doaj.org/article/a4b8378ec734478ab44b6b2ae202004b |
op_doi |
https://doi.org/10.1590/S1678-91992006000400006 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
4 |
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1766338708320026624 |