Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best.
BACKGROUND:Despite control efforts, human schistosomiasis remains prevalent throughout Africa, Asia, and South America. The global schistosomiasis burden has changed little since the new anthelmintic drug, praziquantel, promised widespread control. METHODOLOGY:We evaluated large-scale schistosomiasi...
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ftdoajarticles:oai:doaj.org/article:a43506281070461f9ce798955498eb3a 2023-05-15T15:09:23+02:00 Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. Susanne H Sokolow Chelsea L Wood Isabel J Jones Scott J Swartz Melina Lopez Michael H Hsieh Kevin D Lafferty Armand M Kuris Chloe Rickards Giulio A De Leo 2016-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004794 https://doaj.org/article/a43506281070461f9ce798955498eb3a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4956325?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004794 https://doaj.org/article/a43506281070461f9ce798955498eb3a PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004794 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004794 2022-12-30T23:08:43Z BACKGROUND:Despite control efforts, human schistosomiasis remains prevalent throughout Africa, Asia, and South America. The global schistosomiasis burden has changed little since the new anthelmintic drug, praziquantel, promised widespread control. METHODOLOGY:We evaluated large-scale schistosomiasis control attempts over the past century and across the globe by identifying factors that predict control program success: snail control (e.g., molluscicides or biological control), mass drug administrations (MDA) with praziquantel, or a combined strategy using both. For data, we compiled historical information on control tactics and their quantitative outcomes for all 83 countries and territories in which: (i) schistosomiasis was allegedly endemic during the 20th century, and (ii) schistosomiasis remains endemic, or (iii) schistosomiasis has been "eliminated," or is "no longer endemic," or transmission has been interrupted. PRINCIPAL FINDINGS:Widespread snail control reduced prevalence by 92 ± 5% (N = 19) vs. 37 ± 7% (N = 29) for programs using little or no snail control. In addition, ecological, economic, and political factors contributed to schistosomiasis elimination. For instance, snail control was most common and widespread in wealthier countries and when control began earlier in the 20th century. CONCLUSIONS/SIGNIFICANCE:Snail control has been the most effective way to reduce schistosomiasis prevalence. Despite evidence that snail control leads to long-term disease reduction and elimination, most current schistosomiasis control efforts emphasize MDA using praziquantel over snail control. Combining drug-based control programs with affordable snail control seems the best strategy for eliminating schistosomiasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 7 e0004794 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Susanne H Sokolow Chelsea L Wood Isabel J Jones Scott J Swartz Melina Lopez Michael H Hsieh Kevin D Lafferty Armand M Kuris Chloe Rickards Giulio A De Leo Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Despite control efforts, human schistosomiasis remains prevalent throughout Africa, Asia, and South America. The global schistosomiasis burden has changed little since the new anthelmintic drug, praziquantel, promised widespread control. METHODOLOGY:We evaluated large-scale schistosomiasis control attempts over the past century and across the globe by identifying factors that predict control program success: snail control (e.g., molluscicides or biological control), mass drug administrations (MDA) with praziquantel, or a combined strategy using both. For data, we compiled historical information on control tactics and their quantitative outcomes for all 83 countries and territories in which: (i) schistosomiasis was allegedly endemic during the 20th century, and (ii) schistosomiasis remains endemic, or (iii) schistosomiasis has been "eliminated," or is "no longer endemic," or transmission has been interrupted. PRINCIPAL FINDINGS:Widespread snail control reduced prevalence by 92 ± 5% (N = 19) vs. 37 ± 7% (N = 29) for programs using little or no snail control. In addition, ecological, economic, and political factors contributed to schistosomiasis elimination. For instance, snail control was most common and widespread in wealthier countries and when control began earlier in the 20th century. CONCLUSIONS/SIGNIFICANCE:Snail control has been the most effective way to reduce schistosomiasis prevalence. Despite evidence that snail control leads to long-term disease reduction and elimination, most current schistosomiasis control efforts emphasize MDA using praziquantel over snail control. Combining drug-based control programs with affordable snail control seems the best strategy for eliminating schistosomiasis. |
format |
Article in Journal/Newspaper |
author |
Susanne H Sokolow Chelsea L Wood Isabel J Jones Scott J Swartz Melina Lopez Michael H Hsieh Kevin D Lafferty Armand M Kuris Chloe Rickards Giulio A De Leo |
author_facet |
Susanne H Sokolow Chelsea L Wood Isabel J Jones Scott J Swartz Melina Lopez Michael H Hsieh Kevin D Lafferty Armand M Kuris Chloe Rickards Giulio A De Leo |
author_sort |
Susanne H Sokolow |
title |
Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. |
title_short |
Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. |
title_full |
Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. |
title_fullStr |
Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. |
title_full_unstemmed |
Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best. |
title_sort |
global assessment of schistosomiasis control over the past century shows targeting the snail intermediate host works best. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004794 https://doaj.org/article/a43506281070461f9ce798955498eb3a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004794 (2016) |
op_relation |
http://europepmc.org/articles/PMC4956325?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004794 https://doaj.org/article/a43506281070461f9ce798955498eb3a |
op_doi |
https://doi.org/10.1371/journal.pntd.0004794 |
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PLOS Neglected Tropical Diseases |
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10 |
container_issue |
7 |
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e0004794 |
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